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What is the chemical structure of tert-butyl 1 ', 2' -dihydrospiro [azetidine-3,3 '-pyrrolo [3,2-b] pyridine] -1-carboxylate?
This is an organic compound named tert-butyl 1 ', 2' -dihydrospiro [azacyclobutane-3,3 '-pyrrolido [3,2-b] pyridine] -1-carboxylate. The description of its chemical structure depends on the rules and nomenclature of organic chemistry.
In this compound, the helical ring structure is the key feature. The helical ring is a structure formed by two rings connected by a common atom. In this example, the two rings of azacyclobutane and pyrrolido [3,2-b] pyridine are connected by a helical atom.
Azacyclobutane is a quaternary heterocyclic ring with a nitrogen atom in the ring. Pyrrole [3,2-b] pyridine is a more complex fused ring system, which is formed by fusing pyrrole ring with pyridine ring. Tert-butyl is connected to a specific location in the spiral ring structure, and the formate group is also connected to the corresponding check point of the spiral ring structure.
Tert-butyl is a group of -C (CH 🥰), which has a certain steric hindrance effect. Formate-COO-imparts specific chemical properties and reactivity to the compound. This chemical structure determines that the compound may exhibit unique physical, chemical and biological activities in the fields of organic synthesis, medicinal chemistry, etc.
What are the main uses of tert-butyl 1 ', 2' -dihydrospiro [azetidine-3,3 '-pyrrolo [3,2-b] pyridine] -1-carboxylate?
Tert-butyl 1 ', 2' -dihydrospiro [azacyclobutane-3,3 '-pyrrolido [3,2-b] pyridine] -1-carboxylate, which has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to create a variety of new drugs. Due to its unique molecular structure, it can precisely bind to specific targets in organisms, showing a variety of biological activities, or has antibacterial and antiviral effects, or has anti-tumor and nervous system functions, opening up new paths for drug development.
It also plays an important role in the field of organic synthesis. Through various chemical reactions, such as nucleophilic substitution, addition reactions, etc., it can be cleverly connected with other organic molecules to build complex organic compounds. With this, chemists can expand the structural diversity of organic molecules and contribute key raw materials to the fields of materials science and total synthesis of natural products.
In addition, in pharmaceutical chemistry research, it is often used to optimize lead compounds. Scientists can finely modify its structure and explore the relationship between structure and activity, thereby improving drug efficacy, reducing toxic and side effects, promoting the birth of innovative drugs, and contributing to human health.
What are the methods for synthesizing tert-butyl 1 ', 2' -dihydrospiro [azetidine-3,3 '-pyrrolo [3,2-b] pyridine] -1-carboxylate?
The methods for synthesizing tert-butyl 1 ', 2' -dihydrospiro [azacyclobutane-3,3 '-pyrrolido [3,2-b] pyridine] -1-carboxylic acid esters are various and ingenious. One method is to start with a nitrogen-containing heterocycle and convert it in multiple steps to reach the target product. The starting material needs to be carefully selected and contain suitable substituents so that the subsequent reaction can proceed in an orderly manner.
First, the starting material is subjected to a specific reaction, such as nucleophilic substitution. At this step, precise control of the reaction conditions, such as temperature, solvent, catalyst dosage, etc., will affect the reaction process and product purity. If the temperature is too high or side reactions are clustered, if it is too low, the reaction will be slow or even stagnant. The polarity and solubility of the solvent also affect the activity and reaction selectivity of the reactants.
Then, after the cyclization reaction, the spiral ring structure is constructed. This step requires the selection of appropriate reagents and reaction conditions to promote the formation of intra-molecular rings. In this process, the steric resistance and electronic effect of the reactants have a great impact on the difficulty and selectivity of the cyclization reaction. Fine regulation is required to efficiently generate the target spiral ring product.
Furthermore, protection and deprotection strategies are also commonly used. At an appropriate stage of the reaction, specific functional groups are protected to avoid their being affected in subsequent reactions. After the required reaction is completed, the protective group is precisely removed to obtain the target product. The choice of protecting groups requires both stability and removal convenience.
In addition, catalytic reactions are also commonly used methods. Suitable catalysts can significantly accelerate the reaction process and improve the yield of the reaction. The activity and selectivity of different catalysts vary greatly, so careful screening is required according to the characteristics of the reaction substrate and the target product.
All methods for synthesizing this compound require careful consideration of the reaction mechanism, conditions, reagent selection, etc., so that tert-butyl 1 ', 2' -dihydrospiro [azacyclobutane-3,3 '-pyrrolido [3,2-b] pyridine] -1-carboxylate can be prepared efficiently and with high purity.
Tert-butyl 1 ', 2' -dihydrospiro [azetidine-3,3 '-pyrrolo [3,2-b] pyridine] -1-carboxylate What are the precautions during storage and transportation?
F tert - butyl 1 ', 2' - dihydrospiro [azetidine - 3,3 '- pyrrolo [3,2 - b] pyridine] - 1 - carboxylate is also an organic compound. When storing and transporting, there are several things to pay attention to.
First words storage, this compound should be placed in a cool, dry and well ventilated place. It covers its properties or is affected by temperature and humidity. If it is placed in a warm and humid place, it may deteriorate. If the temperature is too high, it may cause chemical reactions, which will damage its structure and properties; if the humidity is too high, it may cause it to absorb moisture, which in turn affects the purity. And it needs to be kept away from fire and heat sources. Because it may be flammable, it is easy to be dangerous in case of open flames and hot topics.
Furthermore, when storing, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. It is easy to react between different chemical substances, such as contact with oxidants, or cause oxidation reactions, causing compounds to fail, or even violent reactions, endangering safety.
As for transportation, it is necessary to ensure that the packaging is complete and sealed. If the packaging is damaged, compounds or leaks, pollute the environment, and may also endanger the safety of transporters. During transportation, the speed should be stable, and severe vibrations such as sudden braking and sharp turns should be avoided to prevent package damage. At the same time, the means of transportation should also be clean and dry, and there should be no residual substances that react with the compound. Transport personnel should be familiar with the characteristics of the compound and emergency treatment methods. In case of emergencies such as leakage, they can quickly and properly dispose of it to reduce harm. In this way, tert-butyl 1 ', 2' -dihydrospiro [azetidine-3,3 '-pyrrolo [3,2-b] pyridine] -1-carboxylate is guaranteed to be safe and stable during storage and transportation.
What is the market price range for tert-butyl 1 ', 2' -dihydrospiro [azetidine-3,3 '-pyrrolo [3,2-b] pyridine] -1-carboxylate?
Alas! This is a question about the market price range of "tert - butyl 1 ', 2' -dihydrospiro [azetidine - 3,3 '-pyrrolo [3,2 - b] pyridine] -1 - carboxylate". However, I have not obtained detailed data on the market conditions of this particular product, so it is difficult to determine its price. This compound may have its uses in special pharmaceutical research and development, organic synthesis and other fields. Its price may vary depending on purity, difficulty in preparation, and market supply and demand. If it is high purity and complicated to prepare, and the demand is strong, the price may be high; conversely, if it is slightly easier to prepare and sufficient in supply, the price may be slightly cheaper. However, without exact market research, it is difficult to determine its price range. Or you need to ask a merchant who specializes in this chemical, or consult a chemical trading platform or industry expert to obtain a more accurate market price range.