tert-butyl 1,2,3,6-tetrahydropyridine-1-carboxylate

Alas! I want to know the chemical structure of "tert-butyl 1,2,3,6-tetrahydropyridine-1-carboxylate".
In this compound, the "tert-butyl" is tert-butyl. The structure of tert-butyl is a carbon atom connected to three methyl groups, which is in the shape of a trident, and its abbreviation is -C (CH
"1,2,3,6-tetrahydropyridine" part, which is tetrahydropyridine. Pyridine is a six-membered nitrogen-containing heterocycle with a conjugated system. And this is tetrahydropyridine, which means that some of the double bonds on the pyridine ring are hydrogenated and reduced, and the hydrogen atoms at positions 1, 2, 3, and 6 participate in the reaction, resulting in a decrease in the degree of unsaturation of the ring. The nitrogen atom in this ring occupies a vertex, and the rest of the atoms are connected in turn to form a ring.
"1-carboxylate" indicates that there is a carboxyl-derived structure connected to the 1-position of the tetrahydropyridine ring. If the carboxyl-COOH forms an ester bond with other groups, it is a -COO-structure. Here, this carboxyl group is connected to the tert-butyl group to form a tert-butyl ester structure, namely -COO-C (CH 🥰).
In summary, the chemical structure of "tert - butyl 1,2,3,6 - tetrahydropyridine - 1 - carboxylate" is an ester compound formed by connecting the carboxyl group to the tert-butyl group at the first position of the tetrahydropyridine ring. Tert-butyl is attached to the carboxyl group derivative of the tetrahydropyridine ring like a halberd, and the tetrahydropyridine ring has a unique nitrogen-containing heterocycle and is partially saturated.

Tert-butyl 1,2,3,6-tetrahydropyridine-1-carboxylic acid esters have a wide range of uses in the field of organic synthesis. First, it is often a key intermediate for the construction of nitrogen-containing heterocyclic compounds. This compound can interact with a variety of nucleophiles and electrophilic reagents through cleverly designed reaction pathways, thus deriving complex and biologically active nitrogen-containing heterocyclic rings.
Furthermore, it has great achievements in the field of medicinal chemistry. In the design of many drug molecules, tert-butyl 1,2,3,6-tetrahydropyridine-1-carboxylic acid ester structural units are often introduced because they can optimize the physical and chemical properties of drug molecules, such as lipophilicity and solubility, thereby enhancing the bioavailability and pharmacological activity of drugs. < Br >
Because of the synergy effect of tetrahydropyridine ring with tert-butyl and ester groups in its structure, it has also come to the fore in catalytic reactions. It can be used as a ligand to coordinate with metal catalysts, adjust the electron cloud density and steric resistance of the catalyst, and then make the catalytic reaction more selective and active, and has broad application prospects in frontier fields such as asymmetric catalysis.
In the field of materials science, modified tert-butyl 1,2,3,6-tetrahydropyridine-1-carboxylic acid ester derivatives can participate in the polymerization reaction as functional monomers, endowing the polymer with specific optical, electrical or mechanical properties, opening up a new way for the creation of new functional materials.

To prepare tert-butyl 1,2,3,6-tetrahydropyridine-1-carboxylic acid ester, there are various methods for its synthesis.
First, it can be started from a suitable pyridine derivative. First, pyridine is used as a raw material, and under suitable conditions, an electrophilic substitution reaction is used to introduce a group that can be converted into a carboxyl group. This process requires the selection of appropriate reagents and reaction conditions to make the reaction check point accurate to obtain the corresponding pyridine substituent. Then the pyridine ring of the substituent is partially hydrogenated with a suitable catalyst, such as a metal catalyst, to convert the pyridine ring into a 1,2,3,6-tetrahydropyridine structure. At the same time, the introduced substituents are converted into carboxylic acids through a series of reactions, and then esters are formed with tert-butyl alcohol in the presence of condensation reagents to obtain tert-butyl 1,2,3,6-tetrahydropyridine-1-carboxylic acid esters.
Second, it can also be used as a strategy for constructing pyridine rings. For example, nitrogen-containing compounds and suitable unsaturated carbonyl compounds are cyclized under the action of basic catalysts to construct pyridine ring structures. In this process, groups that can be converted into carboxyl groups and tert-butoxy carbonyl groups are introduced at the same time. Subsequent hydrogenation reaction, the pyridine ring is partially hydrogenated, and then the functional group is converted to complete the synthesis of tert-butyl 1,2,3,6-tetrahydropyridine-1-carboxylic acid ester.
During synthesis, attention should be paid to the precise control of reaction conditions, such as temperature, pressure, reaction time, etc., which have a great impact on the reaction process and product yield. At the same time, the purity and dosage of the reagents used also need to be carefully considered to make the reaction efficient and selective to obtain the target product.

Tert-butyl 1,2,3,6-tetrahydropyridine-1-carboxylic acid ester, this is an organic compound. Its physical properties are quite important, and it is related to many chemical processes and practical applications.
First, the appearance. Under normal temperature and pressure, it often takes the form of a colorless to light yellow liquid, with a clear and transparent texture. This appearance feature is easy to observe and distinguish in actual operation, and it is also helpful to judge its purity.
Let's talk about the melting point and boiling point. The melting point is about -20 ° C, which indicates that in a relatively low temperature environment, it will change from liquid to solid. The boiling point is roughly between 240 and 250 ° C. This boiling point characteristic determines that under certain temperature conditions, the substance will undergo a phase change from liquid to gaseous state, which is of great significance in chemical operations such as distillation and separation.
In terms of density, it is about 1.02 - 1.05 g/cm ³, which is slightly heavier than water. This density property is crucial for predicting its distribution and behavior in the system when it involves liquid-liquid separation, mixing, etc.
Solubility cannot be ignored. It is soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. This good solubility provides convenience for organic synthesis as a reaction medium or participating in the reaction, which can promote the reaction to proceed efficiently in a homogeneous system; however, it has little solubility in water, which is closely related to factors such as the polarity difference of water.
In addition, tert-butyl 1,2,3,6-tetrahydropyridine-1-carboxylate also has a certain volatility. Although the volatility is not strong, it will still be partially volatile in an open system or a heated environment. It needs to be considered during operation, and measures such as protection and ventilation should be paid attention to to to ensure experimental safety and operation accuracy.

Futert - butyl 1,2,3,6 - tetrahydropyridine - 1 - carboxylate is one of the organic compounds. Its market prospects depend on various factors.
From the perspective of the pharmaceutical field, this compound may have potential medicinal value. In the process of drug development, it may be a key intermediate, which can help create novel drug molecules. There is a constant demand for high-efficiency and specific active ingredients in the pharmaceutical industry. If this compound can exhibit unique pharmacological activity, be reasonably designed and modified, or can give rise to new drugs to meet the needs of treating diseases, it may have broad prospects in the pharmaceutical market.
In the field of materials science, it may also have application opportunities. If its chemical properties meet the requirements of material synthesis, such as it can participate in the preparation of polymer materials with special properties, endowing the materials with unique mechanical, optical or electrical properties to meet the demand for high-performance materials in the fields of electronics and optical materials, it can occupy a place in the materials market.
However, its market expansion also faces challenges. The complexity and cost of the synthesis process are important factors. If the synthesis steps are cumbersome, the raw materials are rare and expensive, resulting in high production costs, it will limit its large-scale production and application. And the market competition is fierce, and similar or alternative compounds may have occupied part of the market share. If you want to stand out, you need to highlight your own unique advantages.
To sum up, the market prospect of tert-butyl 1,2,3,6-tetrahydropyridine-1-carboxylate has both opportunities and challenges. If we can overcome problems such as synthesis costs and give full play to our own performance advantages, we are expected to achieve considerable development in the pharmaceutical, materials and other markets; conversely, we may be trapped in market competition and limited development.