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What is the role of salicylazosulfapyridine?
Sulfasalazine is a medicine commonly used by physicians. Its efficacy is quite extensive, and it is widely used in various diseases.
The first is its effect on inflammatory bowel diseases. Such as ulcerative colitis, sulfasalazine can relieve symptoms, reduce inflammation in the intestines, and help repair mucous membranes. Damp and heat in the intestines accumulate, causing abdominal pain, diarrhea, mucus, purulent stools, etc. This medicine can clear the damp and heat in the intestines, regulate the vitality of the intestines and organs, and relieve various diseases. The ingredients contained in this medicine can act on the inflammatory mediators in the intestines, inhibit their activity, and reduce the inflammatory response.
It is also effective in rheumatoid arthritis. Rheumatoid diseases are mostly caused by the invasion of wind-cold and damp pathogens, paralysis of meridians and collaterals, and poor qi and blood. Sulfasalazine can help channel meridians and collaterals, conduct qi and blood, slow down joint swelling and pain, and improve joint function. Its mechanism is to regulate the body's immune function, inhibit the excesses of the immune response, and reduce local inflammation of the joints.
In addition, sulfasalazine is also often used for seronegative spinal arthropathy such as ankylosing spondylitis. It can improve the symptoms of the spine and peripheral joints and slow down the progress of the disease. It can help patients relieve pain and stiffness in the lower back and improve the quality of life.
When taking medication, doctors need to examine the patient's body, observe the condition carefully, and weigh the pros and cons. Although the drug is effective, it may also have adverse reactions, such as nausea, vomiting, rash, etc. Therefore, during the medication period, it is necessary to observe it closely and adjust the medication in time to achieve the best therapeutic effect.
What are the side effects of salicylazosulfapyridine?
Salicylazosulfapyridine is sulfasalazine. Although this drug has a therapeutic effect, it also has many side effects, which cannot be ignored.
Its side effects are the first to bear the brunt, which is the impact on the digestive system. After many patients take the drug, nausea and vomiting are common, epigastric discomfort, seems to be blocked, and even nausea is difficult to stop. And there are not a few people with loss of appetite. They see delicious food but have no interest, and their diet is sharply reduced. Diarrhea also occurs from time to time, and the stool is loose and thin, and the number of times increases. This is because the drug stimulates the stomach and causes abnormal transportation.
Furthermore, it also has adverse effects on the blood system. It can cause leukopenia, the number of defense guards of the human body decreases, the resistance is weakened, and it is vulnerable to external evil attacks. Frequent diseases such as colds and colds. It may also cause thrombocytopenia, impaired coagulation function, and petechiae and petechiae may appear on the surface of the body, and it is easy to turn blue if there is a slight collision.
In addition, it also affects the skin. After some patients take the drug, the skin is itchy and intolerable. After scratching, erythema and rash gradually emerge, and even it can develop into exfoliative dermatitis, with large pieces of skin falling off and painful.
In the nervous system, side effects can also be seen. Patients may feel headache, dizziness, and dizziness in the head. If they are wrapped in heavy objects, their thinking is also affected A few people also experience insomnia, tossing and turning at night, difficulty falling asleep, and listlessness during the day.
Some patients may experience liver and kidney damage after taking medication. Liver metabolic function is inhibited, transaminase is elevated, and when it involves the kidneys, it can cause proteinuria, hematuria, etc., and kidney excretion function is impaired.
In short, when using sulfasalazine, doctors should carefully observe the patient's symptoms, weigh the pros and cons, and patients should also pay close attention to their own changes. If there is any discomfort, communicate with the doctor in time to ensure safety.
What is the usage and dosage of salicylazosulfapyridine?
Salicylazosulfapyridine, that is, sulfasalazine, is a commonly used clinical medicine for the treatment of inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease. Its usage and dosage are quite exquisite, and the details are as follows:
** Adult usage and dosage **:
At the beginning, the daily dosage is 2-3 grams, which is taken in 3-4 times. This amount is designed to quickly control the development of the disease and curb the trend of inflammation. When the disease slows down a little, the dose can be gradually reduced, and the maintenance amount is about 1.5 grams a day, which is also taken in 3-4 times to consolidate the curative effect and prevent the recurrence of the disease. For example, when the symptoms of ulcerative colitis initially appear, this method is often used to relieve the symptoms of patients.
** Children's Usage and Dosage **:
Depending on body weight, the daily dosage per kilogram of body weight is 40-60 mg, and it is also taken in 3-4 times. When taking the medicine, it is necessary to pay close attention to the physical reaction of the child. Because of its delicate constitution, the drug tolerance is different from that of adults. If the child weighs 20 kg, the daily dosage is about 800-1200 mg, and then take it in multiple doses.
When taking the medicine, it is also necessary to know that it should be taken after meals, which can reduce the irritation of the drug to the stomach and intestines. And during the medication, it is advisable to drink more water, and the daily drinking water should be more than 1500 ml to prevent crystals in the urine and damage to the kidneys. If the patient's compliance is good, following this dosage and precautions can often achieve a good therapeutic effect and relieve pain.
salicylazosulfapyridine apply to which diseases
Sulfasalazine can be used for a variety of diseases. It is quite effective in inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease. In ulcerative colitis, intestinal inflammation is abundant, sulfasalazine can prevent the spread of inflammation, relieve abdominal pain, diarrhea, sepsis and other diseases, and assist in the repair of intestinal mucosa. Crohn's disease is also a refractory intestinal inflammation. This drug can reduce intestinal ulcers and strictures and control the disease.
Furthermore, patients with rheumatoid arthritis can also rely on this drug. Rheumatoid arthritis causes joint swelling, pain, stiffness, and limited mobility. Sulfasalazine can regulate immunity, relieve joint inflammation, reduce joint damage, improve joint function, and improve patients' quality of life.
In addition, certain spinal arthropathy, such as ankylosing spondylitis, sulfasalazine can also play a role. Ankylosing spondylitis involves the spine and sacroiliac joints, causing pain and stiffness. This drug can reduce inflammation, slow symptoms, and block the progression of the disease.
When taking medication, it is necessary to pay attention to its adverse reactions and use it rationally according to the doctor's instructions to achieve the best curative effect and ensure the health of patients.
What to pay attention to when using salicylazosulfapyridine
If you use sulfasalazine, you should know the following things. This medicine is a commonly used agent for the treatment of intestinal inflammation, and the patient's physical condition should be checked when using it. First ask about the history of allergies. If you are allergic to sulfonamides and salicylic acid drugs, you must not use it, otherwise you may develop serious allergies and endanger your life.
When using medication, the dosage must be accurate. The initial dosage may be slightly larger, and then it will be adjusted gradually according to the condition and tolerance. Do not increase or decrease by yourself. You need to follow the doctor's advice. If the dosage is improper, the efficacy of the medicine will not be reached in the light case, and the adverse reactions may be exacerbated in the severe case.
During the medication period, you need to observe Common adverse reactions include gastrointestinal discomfort, such as nausea, vomiting, abdominal pain, etc. If this condition is serious, the doctor should be notified immediately. There may also be blood system abnormalities, such as anemia and leukopenia, so it is necessary to check the hemogram regularly in order to detect abnormalities early and deal with them in time.
People with hepatic and renal insufficiency should be especially cautious when using this drug. Because of its metabolism through the liver and kidney, the liver and kidney function are not good, or cause drug accumulation, increasing the risk of adverse reactions. During the medication period, it is advisable to drink more water to promote drug excretion and reduce the possibility of urinary tract crystallization formation.
This drug may affect the absorption of folic acid. Long-term users may Pregnant and lactating women should also carefully weigh the pros and cons of medication, as it may have potential effects on the fetus and infant. In short, when using sulfasalazine, all precautions should be kept in mind to ensure the safety and effectiveness of medication.