Rabeprazole
pyridine pyrrole pyrazine piperidine piperazine

Rabeprazole

    Specifications

    HS Code

    972191

    Chemical Name 2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]-1H-benzimidazole
    Molecular Formula C18H21N3O3S
    Molecular Weight 359.44 g/mol
    Category Proton pump inhibitor
    Mechanism Of Action Inhibits the H+/K+ - ATPase enzyme in gastric parietal cells
    Indication Treatment of gastroesophageal reflux disease (GERD), duodenal ulcers, gastric ulcers
    Dosage Form Tablets, delayed - release capsules
    Route Of Administration Oral
    Side Effects Headache, diarrhea, nausea, abdominal pain, dizziness
    Pharmacokinetics Rapidly absorbed, extensive first - pass metabolism

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    Frequently Asked Questions

    As a leading Rabeprazole supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the common side effects of Rabeprazole?
    Rabeprazole is a good medicine for the treatment of gastric acid-related diseases, but there are also some adverse reactions, which cannot be ignored.
    First, common digestive system discomfort. Such as nausea and vomiting, this is caused by drug entry into the body and disturbance of the transportation and transformation of the spleen and stomach. When the stomach qi is reversed, it occurs as nausea and vomiting. Or see the appearance of diarrhea, because the drug affects the normal conduction of the intestines, the water and valley essence are transported and removed, and the turbidity is not divided, so it becomes diarrhea. Another feeling of abdominal distension is that the spleen and stomach are stagnant, the lift and descent are abnormal, and the turbid gas is stagnant in the abdomen.
    Second, nervous system symptoms are not uncommon. Headache, or because the drug affects the flow of qi and blood, the brain and orifices are disnourished, and the meridians are blocked and painful. Those who are dizzy, the qi and blood cannot be honored in the leader, and the clear sun does not rise, so the leader is dizzy. And some people may have a state of drowsiness. This is because the drug interferes with the gods, the spirit is insufficient, the spirit is listless, and then sleepiness.
    Third, in the blood system, it can occasionally cause leukopenia. The human body relies on qi and blood for nourishment. White blood cells are like the genus of qi. Drugs may damage the source of qi and blood biochemistry, or directly injure the positive, causing insufficient leukocyte production, weakened external defense function, and vulnerable to external evil attacks.
    Fourth, long-term or large-scale use may also affect liver and kidney function. The liver and kidney are homologous, and the drug is metabolized by the liver and kidney. If the drug poison accumulates, the function of the liver and the kidney to store essence will be affected, or the function indicators of the liver and kidney will be abnormal, which will affect the operation and metabolism of qi, blood and body fluid of the whole body.
    Those who use this drug should carefully observe the physical changes. If the adverse reactions are serious, they need to seek medical attention in time and adjust the medication according to the doctor's instructions to ensure well-being.
    What are the suitable populations for Rabeprazole?
    Rabeprazole is a good medicine often used to treat stomach-related diseases. It is suitable for a wide range of people, and the following is a detailed description for you.
    The first application is for people with gastric ulcers. Patients with gastric ulcers often feel pain in the epigastric area, and the pain is quite regular. Rabeprazole can inhibit gastric acid secretion, create a good repair environment for the gastric mucosa, help ulcer healing, and relieve the pain of patients.
    This medicine is also suitable for patients with duodenal ulcer. The pain caused by duodenal ulcer is often related to eating, and the patient is quite suffering. Rabeprazole achieves the purpose of treatment by reducing the irritation of stomach acid to the site of duodenal ulcer.
    Furthermore, patients with reflux esophagitis also need this medicine. Such patients often feel heartburn, acid reflux and other discomfort, which seriously affects the quality of life. Rabeprazole can reduce acid reflux, reduce esophageal inflammation, and improve symptoms.
    For people with Helicobacter pylori infection, Rabeprazole is also indispensable. In the combined treatment plan to eradicate Helicobacter pylori, Rabeprazole can improve the efficacy of antibiotics, help completely eliminate Helicobacter pylori, and prevent the recurrence of related diseases.
    In addition, if people frequently experience stomach pain, stomach distension, and heartburn caused by excessive stomach acid, Rabeprazole can also be used after diagnosis. This drug can effectively control gastric acid secretion and relieve uncomfortable symptoms.
    However, it is necessary to keep in mind that the medication must follow the doctor's advice, and must not be used at will to avoid adverse consequences. Only rational drug use can make rabeprazole exert the best therapeutic effect and protect the well-being of patients.
    Does Rabeprazole interact with other medications?
    Rabeprazole is a proton pump inhibitor and is commonly used in the clinical treatment of gastric acid-related diseases, such as gastric ulcer, duodenal ulcer, reflux esophagitis, etc. Whether it interacts with other drugs needs to be carefully examined.
    Rabeprazole is mainly metabolized by the cytochrome P450 enzyme system, so it may interact with drugs metabolized by this enzyme system. Take clopidogrel as an example. This is an antiplatelet drug and is often used to prevent cardiovascular events. Clopidogrel needs to be metabolized into an active product by the liver cytochrome P450 enzyme system to be effective. Rabeprazole has an affinity with CYP2C19 in this enzyme system. When used in combination, Rabeprazole may inhibit the activity of CYP2C19, reduce the production of clopidogrel active metabolites, reduce the antiplatelet efficacy, and then increase the risk of cardiovascular events.
    Another drug such as diazepam, phenytoin sodium, etc., is also metabolized by the cytochrome P450 enzyme system. Rabeprazole is used in combination with it, or it affects the metabolic process of these drugs, causing changes in their blood concentration. If the blood concentration increases, it may increase the chance of adverse reactions; if the blood concentration decreases, it may impair the efficacy.
    When taken with antacids, attention should also be paid. Although rabeprazole itself is an acid suppressant, if used in combination with antacids, antacids may change the pH value in the stomach, which in turn affects the absorption of rabeprazole.
    In addition, some antibacterial drugs such as amoxicillin and clarithromycin are often combined with rabeprazole to form a triple or quadruple therapy to eradicate Helicobacter pylori. In this case, instead of having adverse interactions, the rational combination of rabeprazole can be used to inhibit acid to create a gastric environment suitable for the efficacy of antibacterial drugs and improve the success rate of radical treatment of Helicobacter pylori.
    In summary, when rabeprazole is combined with other drugs, there may be interactions. When using clinical medication, physicians must know the patient's medication history in detail and carefully evaluate the possibility of drug interactions to ensure the safety and efficacy of medication.
    How to Take Rabeprazole Properly
    Rabeprazole is a good medicine for treating epigastric diseases, but the correct method of taking it needs to be determined in detail.
    If it is used to treat gastric ulcers, duodenal ulcers and anastomotic ulcers, the conventional method is that adults take 20 mg once a day, and it is advisable to take it with warm water in the early morning. Generally speaking, the treatment period for gastric ulcers is about six weeks, the treatment period for duodenal ulcers is about four weeks, and the treatment period for anastomotic ulcers is about eight weeks.
    If it is used to treat reflux esophagitis, adults should also take 20 mg once a day and take it warmly in the early morning. The general treatment period is eight weeks. For repeated disease patients, when maintaining treatment, once a day, 10 mg at a time is sufficient.
    As for the eradication treatment of Helicobacter pylori, it is often necessary to combine it with antibiotics and other drugs. The common plan is to take 20 milligrams once a day for adults, 1000 milligrams of amoxicillin and 500 milligrams of clarithromycin, both twice a day, and the course of treatment is usually seven to fourteen days.
    When taking medicine, be sure to follow the doctor's advice and do not increase or decrease the dose without authorization. If there is any discomfort during taking the medicine, or if the symptoms do not improve, you should seek medical attention immediately. And it is necessary to know that the reaction of different individuals to the medicine may vary, so the specific medication details should be accurately determined by the doctor according to the individual's condition.
    How long is the usual course of treatment for Rabeprazole?
    In the case of rabeprazole, the question of the treatment period is related to the need for medical medication. The length of the treatment period is not universal, and must be determined according to the patient's symptoms, the severity of the disease and individual differences.
    If it is a common epigastric noisy, pantothenic acid disease, or a new gastritis, the evil qi is not deep, and the righteousness is not seriously injured, the treatment with rabeprazole can be treated as short as two weeks, or it can be effective. This is the light of the evil qi. When the medicine arrives at the hospital, the evil is gone and it is safe.
    However, if the disease is a gastric ulcer, the formation of the ulcer is not a cold day, the stomach organs are damaged, and the qi and blood are lost. At this time, it usually takes four to six weeks to treat with rabeprazole. If you want to make the ulcer calm down and the gastric membrane regenerate, it can be done in a short time. You must wait for the qi and blood to gradually recover and the wound to heal before you can heal.
    As for erosive gastritis and the disease persists, or accompanied by Helicobacter pylori disturbance, the stomach and organs have been sick for a long time, mixed with reality and reality, and the treatment period is longer, or it takes eight weeks, or even months. It needs to be slowly treated to help the right and eliminate evil, so that the stomach and organs can return to their normal way.
    And when taking medicine, the doctor must carefully observe the condition of the patient, observe the response of his medication, and make profits and losses at any time. If the symptoms are reduced after the drug, the dose can be gradually reduced; if the condition is stubborn, it may also need to be combined with other drugs and used synergistically to achieve the best effect. In general, the rabeprazole treatment period is impermanent, and your mileage may vary.