(R,R)-2,2'-(2,6-Pyridinediyl)Bis(4-Isopropyl-2-Oxazoline)

(R, R) -2,2 '- (2,6-pyridyl diyl) bis (4-isopropyl-2-oxazoline) has important applications in many fields.
In the field of catalysis, it often participates in various asymmetric catalytic reactions as a chiral ligand. Due to its unique chiral structure, it can induce the reaction to selectively generate products of specific configurations. For example, in asymmetric hydrogenation, the substrate can be converted into the target product with high enantioselectivity, which greatly improves the reaction efficiency and product purity, and is of great significance for industries such as drug synthesis and fine chemical preparation.
In the field of metal-organic chemistry, it can coordinate with a variety of metal ions to form stable complexes. These complexes have unique properties and play a key catalytic role in organic synthesis reactions, such as the construction of carbon-carbon bonds and carbon-heteroatom bonds, providing an efficient way for the construction of organic molecules.
In the field of medicinal chemistry, because it can participate in asymmetric synthesis reactions, it helps to prepare optically active drug intermediates, and then synthesize single-chiral drugs. Single-chiral drugs often have better efficacy and lower side effects, which can significantly promote the development of new drugs.
In materials science, (R, R) -2,2 '- (2,6-pyridyl) bis (4-isopropyl-2-oxazoline) and its metal complexes can be used to prepare chiral functional materials. These materials have potential applications in nonlinear optics, chiral recognition, separation, etc., such as the design and synthesis of chiral adsorbents for the resolution of racemic mixtures to achieve efficient separation.

To prepare (R, R) -2,2 '- (2,6-pyridyl) bis (4-isopropyl-2-oxazoline), the method is as follows:
Take the pyridine first, and modify it in several steps to introduce a specific group at the 2,6 position. This is a key initial step. Careful control of reaction conditions, such as temperature, solvent, and reactant ratio, is required to ensure the accuracy and efficiency of introducing groups.
Then, the modified pyridine derivative is condensed with a precursor containing isopropyl and oxazoline structures. This step is quite important and affects the structure and purity of the product. The appropriate catalyst needs to be selected to promote the condensation process and inhibit the occurrence of side reactions.
During the reaction process, the monitoring of the reaction system is indispensable. Through analytical methods such as thin-layer chromatography and nuclear magnetic resonance, real-time insight into the reaction process, timely adjustment of reaction parameters, to ensure that the reaction proceeds according to the expected path.
After the reaction is completed, the separation and purification of the product cannot be ignored. Column chromatography, recrystallization and other methods can be used to remove impurities and improve the purity of the product to obtain high-purity (R, R) -2,2 '- (2,6-pyridyl) bis (4-isopropyl-2-oxazoline). All steps need to be taken with caution, following chemical principles and experimental norms, in order to successfully achieve the synthesis of the target product.

The physicochemical properties of (R, R) -2,2 '- (2,6-dimethylbenzene) bis (4-isopropyl-2-oxazoline) are as follows:
Appearance properties, often white to off-white crystalline powder, fine texture, under normal light and room temperature environment, the properties are relatively stable, no obvious spontaneous changes.
In terms of solubility, it exhibits certain solubility properties in organic solvents. For example, in the common organic solvent dichloromethane, it can present a good dissolution state and form a uniform transparent solution, just like white sand integrated into water, quietly dispersed; in chloroform, it can also be dissolved, but the solubility is slightly inferior to that of dichloromethane; while in non-polar solvents such as petroleum ether, the solubility is extremely low, as if sand and gravel are thrown into oil, it is difficult to melt.
The melting point range is usually between 130 and 135 ° C. When the temperature gradually rises to this range, this substance will gradually melt from solid to liquid like ice and snow in the warm sun, and the melting point interval is relatively fixed, which can be used as an important physical indicator for the identification of this substance. < Br >
The thermal stability is quite impressive. When the temperature is below the melting point, the chemical structure does not change significantly after being heated for a long time, just like a tough rock, which does not move in the face of heat attack; but when the temperature is higher than the melting point, the chemical structure may change slowly over time, or cause reactions such as intermolecular rearrangement due to heat.
In terms of chemical activity, the oxazoline ring structure contained in this substance gives it a certain reactivity. For example, under specific catalysts and suitable reaction conditions, oxazoline rings can undergo a ring-opening reaction with compounds containing active hydrogen, just like a delicate mechanical device meets a suitable part, skillfully combining to open a new chemical process; its isopropyl structure may also undergo oxidation under certain strong oxidation conditions, generating corresponding oxidation products.

(R, R) -2,2 '- (2,6-phenylenediyl) bis (4-isopropyl-2-oxazoline) has unique properties in catalytic reactions. The structure of this compound is exquisite, and the (R, R) configuration of the chiral center gives it significant enantioselectivity. In the field of asymmetric catalysis, this property is like a shining star, opening up a way to obtain high-purity single chiral products.
The 2,6-phenylenediyl in its structure is like a solid bridge, which closely connects the two oxazoline structural units, not only enhances the rigidity of the molecule, but also carefully regulates the spatial arrangement of the catalytic activity check point. As for the 4-isopropyl-2-oxazoline part, the introduction of isopropyl precisely adjusts the electron cloud density and spatial environment of the active center through the synergistic effect of steric hindrance and electronic effect.
During the catalytic reaction, (R, R) -2,2 '- (2,6-phenylenediyl) bis (4-isopropyl-2-oxazoline) can specifically bind to the substrate, guiding the reaction in a specific direction with its unique spatial structure and chiral environment. For example, in many reaction types such as asymmetric addition reactions and cyclization reactions, it can demonstrate excellent catalytic performance, with high activity and high selectivity, to help generate the target product. In the field of organic synthesis, especially in the preparation of enantiomeric pure compounds, it is undoubtedly a crucial tool, promoting organic synthesis chemistry towards a more accurate and efficient state.

(R, R) -2,2 '- (2,6-pyridyl diyl) bis (4-isopropyl-2-oxazoline), the price of this product in the market often varies depending on quality, source, supply and demand.
Looking at the description of "Tiangong Kaiwu" today, its feelings in various things are recorded in detail. However, (R, R) -2,2' - (2,6-pyridyl diyl) bis (4-isopropyl-2-oxazoline), I may not have heard of it when "Tiangong Kaiwu" was written, so it is difficult to find its price here.
At present, this product in the market, if it is of ordinary quality and the quantity is small, it costs tens of yuan per gram; if it is high purity and the quantity is huge, the price should be different. And if you buy it from a large factory, the quality is excellent, and the price is high; if you buy it from a small factory, the price may be slightly lower. However, the market situation changes, and merchants often adjust the price due to time and demand. If you want to know the exact price, you need to ask the chemical material market, chemical reagent dealers, or find it on the online professional chemical trading platform to get the current real price.