Pyridine, 5-fluoro-2-nitro-

"5-Fluoro-2-nitropyridine" This substance has unique chemical properties. It is a nitrogen-containing heterocyclic compound with different properties due to the substitution of fluorine and nitro groups.
From the perspective of physical properties, at room temperature, it may be a solid, and the color state may vary depending on the purity. The melting point and boiling point are affected by intermolecular forces. The introduction of fluorine and nitro groups changes the polarity of the molecule, and the melting point and boiling point are different from those of the parent pyridine. And due to the increase in polarity, the solubility in polar solvents may be improved.
In terms of chemical properties, nitro is a strong electron-absorbing group, which decreases the electron cloud density of the pyridine ring, making the electrophilic substitution reaction more difficult. The reaction check point is also specific due to the localization effect of nitro and fluorine. In the case of nucleophilic substitution, fluorine atoms can be used as leaving groups. Due to the large electronegativity of fluorine atoms, the C-F bond is polar, which is conducive to the attack of nucleophilic reagents.
This compound has a wide range of uses in the field of organic synthesis and can be used as a key intermediate. It is of great significance in the fields of pharmaceutical chemistry and materials science by means of nucleophilic substitution, reduction and other reactions.

The product involved in "pyridine, 5-fluoro-2-nitro" has a wide range of uses. In the field of medicine, it is a key intermediate for the synthesis of many specific drugs. For example, when developing some antibacterial drugs for specific bacterial infections, this substance can participate in the construction of the core part of drug activity by virtue of its unique chemical structure, which helps the drug to act efficiently and accurately on the target of pathogens, interfering with the normal physiological metabolism of pathogens, thereby inhibiting the growth and reproduction of pathogens.
In the field of pesticides, it is an important raw material for the creation of new and efficient pesticides. Due to its special chemical properties, the synthetic pesticides have strong contact and stomach toxicity effects on pests. For example, it can precisely destroy the nervous system of pests or interfere with their respiratory system, achieve efficient insecticide, and is relatively friendly to the environment, with low residue, which can effectively reduce the adverse impact on the ecological environment.
In materials science, it can be used as a starting material for the preparation of special functional materials. After a specific chemical reaction, its structure can be introduced into polymer materials, giving the materials unique properties such as good photoelectric properties or special thermal stability. For example, in the preparation of organic photoelectric materials, adding substances containing this structure can optimize the charge transport capacity of materials, improve the photoelectric conversion efficiency of materials, and lay the foundation for the development of new photoelectric devices.

To prepare "5-fluoro-2-nitropyridine", the method is as follows:
Fluoropyridine is often used as the starting material. First take an appropriate amount of 2-chloro-5-fluoropyridine, which is a readily available compound. Place it in a suitable reactor and add a nitro-containing reagent, such as a mixed acid system of nitric acid and sulfuric acid. In this mixed acid system, nitric acid can provide nitro groups, and sulfuric acid acts as a catalyst and dehydration. The reaction temperature is controlled in a moderate range, between about 50 and 80 degrees Celsius. During the reaction duration, the chlorine atom of 2-chloro-5-fluoropyridine reacts with the nitro group in the mixed acid to gradually generate 5-fluoro-2-nitropyridine.
After the reaction is completed, the separation and purification steps need to be carried out. First, the reaction mixture is extracted with a suitable organic solvent, such as dichloromethane, and the product is transferred to the organic phase. Then, the organic solvent and unreacted raw materials are removed by distillation according to the different boiling points of each component. Then, column chromatography can be used to select suitable silica gel as the stationary phase, and the mixed liquid of n-hexane and ethyl acetate in a certain proportion can be used as the mobile phase to further purify the product to obtain pure 5-fluoro-2-nitropyridine.
There are also 2-amino-5-fluoropyridine as the starting material. It is first diazotized, and the amino group is converted into a diazonium salt by reacting sodium nitrite with an inorganic acid (such as hydrochloric acid) at a low temperature (about 0 to 5 degrees Celsius). 5-Fluoro-2-nitropyridine was prepared by substituting nitro with diazo group through Sandmeier reaction. The post-treatment steps were similar to those of 2-chloro-5-fluoropyridine, and the products were purified by extraction, distillation and column chromatography.

When storing and transporting "pyridine, 5-fluoro-2-nitro" products, many things need to be paid attention to.
First of all, this product may be more active and highly susceptible to environmental factors. First of all, it needs to be placed in a cool, dry and well-ventilated place. Because of high temperature, it is easy to change its chemical properties or cause adverse conditions such as decomposition; humid environment may cause the product to be damp, affecting its purity and quality. Secondly, it is necessary to ensure the tightness of the storage container. If the container is not well sealed, the product is easy to react with oxygen, water vapor and other substances in the air, resulting in deterioration. Furthermore, the product should be stored separately from oxidants, reducing agents, acids, bases and other substances. Due to its chemical properties, coexisting with these substances is very likely to cause violent chemical reactions and even cause danger.
As for transportation, there are also many points. During transportation, it is necessary to ensure that the packaging is stable and tight. If the packaging is damaged and the product leaks, it will not only cause losses, but also pose a threat to the transportation environment and personnel safety. At the same time, the means of transportation must be kept clean and dry to avoid mixing with other substances that may react with it. In addition, the transporter should be familiar with the characteristics of the product and emergency treatment methods. In the event of an unexpected situation during transportation, such as leakage, measures can be taken quickly and correctly to reduce the harm. In conclusion, the storage and transportation of "pyridine, 5-fluoro-2-nitro" products requires careful treatment and proper operation to ensure product quality and safety.

What you are inquiring about is the market price range of "5-fluoro-2-nitropyridine". However, the price of this chemical cannot be generalized, and it varies due to many reasons.
First, the difference in purity has a great impact on the price. If the purity is extremely high, it is almost pure and flawless, and its price is high; if it contains impurities and the purity is slightly lower, the price will also drop. High purity can be used in scientific research experiments, with strict requirements and difficult preparation, so the price is high; while general purity, or used in some aspects of industrial production, the price is relatively flat.
Second, the amount of quantity also affects the price. When purchasing in bulk, merchants may make profits due to large quantities, and the unit price tends to be lower; if only a small amount is purchased, it is used for research attempts, etc., due to cost sharing, etc., the unit price is often high.
Third, the trend of market supply and demand is the key factor. If there are many people who need it at a time, the supply is in short supply, and the price will rise; if the supply exceeds the demand, the merchant will sell the goods, and the price may drop.
Fourth, the cost of raw materials and the preparation process are also related to the price. The raw materials are rare, the preparation is complicated, and the exquisite craftsmanship and high cost are required, and the product price is high; if the raw materials are easy to obtain and the process is simple, the price may be close to the people.
Overall, the market price of "5-fluoro-2-nitropyridine" can range from a few yuan per gram to tens of yuan per gram or even higher. It depends on the above factors, and it is difficult to accurately determine its range.