Pyridine 5 Chloro 2 Fluoro 3 Nitro
pyridine pyrrole pyrazine piperidine piperazine

Pyridine, 5-chloro-2-fluoro-3-nitro-

    Specifications

    HS Code

    256405

    Chemical Formula C5H2ClFN3O2
    Appearance Typically a solid (physical state can vary based on conditions)
    Melting Point Data may vary, needs experimental determination
    Boiling Point Data may vary, needs experimental determination
    Solubility In Water Expected to be low, as it's an organic nitro - halopyridine compound
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Pka Data may vary, depends on the acidic/basic nature of relevant functional groups
    Density Data may vary, needs experimental determination
    Vapor Pressure Low, as it is a relatively non - volatile compound

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    Frequently Asked Questions

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    What are the physical properties of 5-chloro-2-fluoro-3-nitropyridine?
    5-Alkane-2-ene-3-carbonyl pyridine is an organic compound, and its physical properties are as follows:
    Viewed at room temperature and pressure, this compound is usually in a liquid or solid state. The specific state varies depending on the intermolecular force, relative molecular weight and molecular structure. If the intermolecular force is strong, the relative molecular weight is large and the structure is tight, the possibility of solid state is large; conversely, the possibility of liquid state is large.
    Smell, such organic compounds may have a special smell. However, the exact smell is difficult to describe accurately, because the smell of organic compounds is complex, some have a pungent smell, and some have an aromatic smell. The smell of this compound needs to be determined by actual sniffing.
    When it comes to the melting point, it is affected by the intermolecular force. There is a van der Waals force between molecules, and there is a dipole-dipole force when there are polar groups. If there are groups such as hydroxyl groups in the molecule that can form hydrogen bonds, the melting boiling point will be significantly increased. 5-Alkane-2-ene-3-carbonyl pyridine has a relatively high melting boiling point due to its large polarity and strong intermolecular force due to its carbonyl and pyridine ring.
    As for solubility, according to the principle of "similar miscibility", because it is an organic compound, it has better solubility in organic solvents such as ethanol, ether, and chloroform. Because organic solvents are structurally similar to this compound, intermolecular forces can interact and be miscible. However, the solubility or poor in water, water is a polar molecule, and the structure of the organic compound is very different. Unless the compound can form special interactions such as hydrogen bonds with water, it is difficult to dissolve in water.
    In terms of density, its density is closely related to molecular weight and molecular structure. The relative molecular weight is large and the molecules are closely arranged, and the density is large; vice versa. Compared with common organic solvents or water, it can be roughly inferred according to its molecular characteristics. Generally speaking, the density of the organic compound is similar to that of common organic solvents, slightly greater than that of non-polar organic solvents, and less than the density of water.
    What are the chemical properties of 5-chloro-2-fluoro-3-nitropyridine?
    5-Bromo-2-pentene-3-one, this is an organic compound. Its chemical properties are unique and have many important manifestations.
    From the perspective of nucleophilic reactions, carbonyl carbons are positively charged due to their strong electronegativity, making them vulnerable to nucleophilic attack. For example, under the catalysis of acids or bases, nucleophilic addition reactions can occur with alcohols to form acetal or hemiacetal structures. This is because the oxygen atom of the alcohol is rich in electrons, launching a nucleophilic attack on carbonyl carbons, thereby forming new carbon-oxygen bonds.
    In the conjugated system, the compound is conjugated with a carbon-carbon double bond and a carbonyl group. This conjugate structure gives it special stability and changes the electron cloud distribution of the double bond. The conjugate system reduces the energy difference between the excited state and the ground state of the molecule, and has a specific absorption peak in the ultraviolet spectrum, which is very critical in the identification of the compound structure. In addition, the conjugate effect affects the reactivity, making the double bond part more prone to electrophilic addition reactions. For example, when adding to hydrogen halide, hydrogen ions are added to the higher electron cloud density of the conjugated system to form a stable carbon-cation intermediate, and then halogen ions are combined with it.
    Allyl bromide structure is also one of its important properties. The allyl carbon-bromide bond is affected by the conjugation effect of allyl, which enhances the activity of bromine atoms. In the nucleophilic substitution reaction, the allyl carbon positive ion is stable due to conjugation, so the bromine atom of the compound is easily replaced by nucleophilic reagents. Like reacting with sodium cyanide, the cyanyl group will replace the bromine atom to form a new compound containing cyanide.
    In addition, the carbonyl group of 5-bromo-2-pentene-3-one can also undergo a reduction reaction. Using a suitable reducing agent, such as sodium borohydride, the carbonyl group can be reduced to an alcohol hydroxyl group to obtain 5-bromo-2-pentene-3-ol. If a stronger reducing agent is used, such as lithium aluminum hydride, in addition to the carbonyl group being reduced, the carbon-carbon double bond may also be reduced to form a saturated alcohol compound.
    What is the common synthesis method of 5-chloro-2-fluoro-3-nitropyridine?
    5-Bromo-2-pentene-3-one, which is a very important compound in the field of organic synthesis. Its common synthesis methods, let me explain in detail for you.
    First, it can be prepared by the alkylation reaction of β-dicarbonyl compounds. Select suitable β-dicarbonyl compounds, such as ethyl acetoacetate, under the action of strong bases, to form carbon negative ions. This carbon negative ion has strong nucleophilic properties and can undergo nucleophilic substitution reactions with bromine-containing halogenated hydrocarbons. For example, by reacting with 1-bromo-2-pentene, the corresponding substituent can be introduced, and then the target product 5-bromo-2-pentene-3-one can be obtained through subsequent steps such as hydrolysis and decarboxylation. The advantage of this method is that the reaction conditions are relatively mild, the raw materials are easy to obtain, and the reactivity of β-dicarbonyl compounds is easy to regulate. However, it also has disadvantages. If there are many reaction steps, the total yield may be limited, and during the alkylation process, side reactions may occur, and the reaction conditions need to be precisely controlled.
    Second, the nucleophilic substitution reaction of enol ethers is used to synthesize. The corresponding enol ether is prepared first, and the double bond and oxygen atom of the enol ether give it a special electron cloud distribution, which makes it have certain nucleophilicity. When it encounters a bromine-containing electrophilic reagent, the bromine atom of the electrophilic reagent can undergo nucleophilic substitution reaction with the enol ether to form a bromine-containing intermediate. Subsequently, through appropriate hydrolysis or other conversion steps, the intermediate is converted to 5-bromo-2-pentene-3-one. The advantage of this method is that the reaction selectivity of the enol ether is good, and the regional selectivity of the target product can be controlled by designing the structure of the enol ether. However, the preparation of enol ethers may require special reaction conditions and reagents, which increases the complexity of the synthesis.
    Third, the synthesis is based on conjugate addition reaction. Select a suitable conjugate system, such as α, β-unsaturated ketones, to undergo conjugate addition reaction with bromine-containing nucleophiles. The bromine atom of the bromine-containing nucleophile can be added to the β-position of the conjugated system to form a new carbon-bromine bond, and at the same time construct the carbon skeleton of the target product. This method can effectively utilize the electronic effect of the conjugated system to realize the functionalization of the specific position of the target compound. However, the conditions of the conjugate addition reaction need to be carefully optimized, otherwise it may lead to poor selectivity of the addition position or other side reactions.
    In which fields is 5-chloro-2-fluoro-3-nitropyridine used?
    5-Bromo-2-pentene-3-one has a wide range of uses. In the field of medicine, it is often a key intermediate for the synthesis of many specific drugs. Due to the unique chemical structure of this compound, it can participate in a variety of chemical reactions and help build complex drug molecular structures. For example, in the synthesis path of some anti-tumor drugs, 5-bromo-2-pentene-3-one can introduce specific functional groups through clever organic synthesis steps, shape the spatial configuration required for drug activity, and enhance the affinity between the drug and the tumor cell target, thereby enhancing the anti-tumor efficacy.
    In the field of materials science, it also has outstanding performance. It can be used as an important raw material for the synthesis of functional materials. For example, when preparing organic materials with special optical or electrical properties, 5-bromo-2-pentene-3-one can give the material unique photoelectric conversion properties through specific polymerization reactions or modifications. In this way, the obtained materials can be applied to cutting-edge electronic devices such as organic Light Emitting Diodes (OLEDs) and solar cells to improve the performance and efficiency of the devices.
    In the field of organic synthesis chemistry, 5-bromo-2-pentene-3-one is like a "master key", which is a common building block for the construction of complex organic molecules. Organic chemists can flexibly design reaction routes based on the activity of their double bonds, carbonyl groups and bromine atoms, and realize the construction of various carbon-carbon bonds and carbon-heterogeneous bonds. Through ingenious regulation of reaction conditions and selection of reagents, organic compounds with different structures and unique functions can be synthesized, injecting continuous vitality into the development of organic synthetic chemistry.
    In short, 5-bromo-2-pentene-3-one plays a pivotal role in many fields such as medicine, materials science and organic synthesis due to its unique chemical properties, promoting continuous progress and innovation in related fields.
    What is the market outlook for 5-chloro-2-fluoro-3-nitropyridine?
    Today, there are 5-bromo-2-pentene-3-keto groups, and their market prospects are related to many reasons.
    The supply and demand of the city is the most important. This compound is often used as an intermediate in the field of medicinal chemistry. Today's pharmaceutical research and development is booming, and many new drugs need this as a basis to construct complex molecular structures. If there are more new diseases and more investment in pharmaceutical research and development, the demand for this substance will increase, and the market situation will improve.
    Furthermore, the advancement of technology is also the key. If the method of preparing 5-bromo-2-pentene-3-ketone is more and more refined, the yield will increase, and the cost will decrease, it will be more competitive in the market. It can expand its application domain, attract more users, and expand the market.
    And the competition in the market cannot be ignored. If there are many competitors competing to make and sell, the supply will exceed the demand, and the price will fall, and the profit will be reduced. However, if it can have unique technical excellence, high quality, and well-rounded service, it can also emerge in the competition and occupy a seat in the market.
    As for the guidance of policies, it also has an impact. Environmental protection regulations, if the cost of preparation rises, or the production capacity is limited. However, encouraging innovative strategies can also promote its R & D refinement and explore new ways of use.
    In summary, the market prospect of 5-bromo-2-pentene-3-ketone base, although there are advantages of demand growth and technological progress, there are also competition and policy variables. Those who are good at observing time changes and studying technology carefully are expected to achieve good results in the market.