Pyridine 5 Bromo 2 3 Difluoro
pyridine pyrrole pyrazine piperidine piperazine

Pyridine, 5-bromo-2,3-difluoro-

    Specifications

    HS Code

    394756

    Chemical Formula C5H2BrF2N
    Molecular Weight 208.98
    Appearance Solid (Typical)
    Solubility In Organic Solvents Likely soluble in common organic solvents

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    General Information
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    Frequently Asked Questions

    As a leading Pyridine, 5-bromo-2,3-difluoro- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 5-bromo-2,3-difluoropyridine?
    5-% E6% BA% B4-2, 3-%E4%BA%8C%E6%B0%9F%E5%90%A1%E7%B1%BB%E5%88%AB%E5%B1%9E%E5%90%8C%E7%94%B2%E9%86%87%E7%B1%BB%E5%8C%96%E5%90%88%E7%89%A9, its physical rationality is special, and the description is as follows:
    This object is usually liquid under the pressure, and the color is clear, almost dark, just like clear water. Then, it is slightly light. The ground is as free as water, the viscosity is low, and it is poured down, like a meandering stream, and it feels like
    Smell its smell, there is a light but not strong fragrance, and it contains a fatty fragrance. It is not pungent, but like a faint breath, which is thought-provoking. As for the taste, it is sweet and sour in the light, bitter and spicy, with a neutral taste. The entrance is slightly clear, and the taste is less.
    The density of the phase is not large, and it is often a liquid. If it drops on the water surface, it can float on the surface, such as a boat wave. In terms of solubility, it can be dissolved in many ways, such as ethanol and ether. When the two meet, they are instantly mixed, regardless of each other. However, the solubility in water is not good, and it drips into the water and disperses on the water surface like oil droplets, so it can be melted.
    The property of this object is low, and if it is placed in the open, it can be measured, and it will soon disappear, just like the water. Its boiling time is not high, and it will melt and steam for a little time, just like the fairy. And its performance is weak, and it is not close to the water, but it can be used to melt.
    In addition, 5-% E6% BA% B4-2, 3-%E4%BA%8C%E6%B0%9F%E5%90%A1 material rationality makes it one in many materials, and it has its own application in chemical industry, chemical industry and other fields, and can achieve special effects.
    What are the chemical properties of 5-bromo-2,3-difluoropyridine?
    5-% Hydroxy-2,3-dienovaleric acid, its chemical properties are as follows:
    This substance is acidic, because it contains carboxyl groups, it can neutralize with bases. In case of sodium hydroxide, the two interact, the hydrogen in the carboxyl group dissociates, combines with hydroxide to form water, and generates the corresponding carboxylate and water, and the reaction is smooth and easy to control.
    also has the characteristics of alkenyl groups. Its carbon-carbon double bonds are rich in electrons and are vulnerable to attack by electrophilic reagents, resulting in electrophilic addition reactions. Taking bromine water as an example, after the polarization of the bromine molecule, the positively charged end is close to the double bond, and the double bond electron cloud is offset and bound to it. At the same time, the negative bromine ion is added to the other double bond carbon, causing the bromine water to fade. This reaction phenomenon is significant and is often used as a method for olefin identification.
    can also occur oxidation reaction. Because the carbon-carbon double bond is relatively active, under the action of a specific oxidant, the double bond can be broken. In case of strong oxidant potassium permanganate, depending on the reaction conditions, the product may be carboxylic acid, ketone, etc. If the conditions are severe, the carbon chain is disconnected at the double bond to form a small molecule oxidation product. This process is often accompanied by color changes, which can be used as a basis for qualitative analysis.
    In addition, the hydroxyl group of the substance also gives it Hydroxy hydrogen has a certain acidity, although it is less acidic than carboxyl hydrogen, it can also undergo substitution reaction under specific conditions. If reacted with hydrogen halide, the hydroxyl group can be replaced by halogen atoms to form halogenated hydrocarbons. This reaction is often used in organic synthesis to introduce halogen functional groups to expand the reaction path and application scope of compounds.
    What are the main uses of 5-bromo-2,3-difluoropyridine?
    5-% hydrazine-2,3-dicarboxylic acid is mainly used in many important fields. In the field of chemical synthesis, this substance can be used as a key intermediate. Due to its unique structure, it can participate in many organic reactions and assist in the synthesis of other difficult-to-obtain compounds. For example, when building a specific ring structure or introducing a special functional group, 5-hydrazine-2,3-dicarboxylic acid can act as a bridge, making the reaction follow the expected path, and then achieve the synthesis of the target product.
    In the field of pharmaceutical research and development, 5-hydrazine-2,3-dicarboxylic acid also has potential application value. Due to its potential to interact with certain molecules in living organisms, it may be used as a lead compound for researchers to further explore its biological activity. By modifying and optimizing its structure, it is very likely to develop new drugs for the treatment of specific diseases.
    In terms of materials science, this substance may be able to participate in the preparation process of materials and give special properties to materials. For example, in the preparation of some functional polymer materials, 5-hydrazine-2,3-dicarboxylic acids can be used as cross-linking agents or modifiers to improve the mechanical properties, thermal stability or optical properties of materials, thereby expanding the application range of materials.
    In addition, in the production of some fine chemical products, 5-hydrazine-2,3-dicarboxylic acid can also be used as an additive to improve the quality and performance of the product. In short, 5-hydrazine-2,3-dicarboxylic acid has shown important uses in many fields due to its unique chemical structure, providing strong support for the development of various fields.
    What are the synthesis methods of 5-bromo-2,3-difluoropyridine?
    There are many methods for the synthesis of 5-bromo-2,3-dienyl pentanone, the common ones are listed as follows:
    First, the alkenyl-containing halogen and carbonyl compound are used as raw materials, and nucleophilic substitution and subsequent reactions are prepared. First, appropriate alkenyl halogenated hydrocarbons are taken to make them react with active carbonyl compounds under the catalysis of bases. The base can be selected from potassium carbonate, potassium tert-butyl alcohol, etc., depending on the activity of the substrate. The reaction is carried out in suitable organic solvents, such as N, N-dimethylformamide (DMF), tetrahydrofuran (THF). After nucleophilic substitution, depending on the specific situation, it may need to go through steps such as elimination and rearrangement to construct the relative position of the double bond and carbonyl of the target molecule to achieve the synthesis of 5-bromo-2,3-dienepentanone.
    Second, through the reaction of enolides. Select suitable ketones and form enolides under the action of strong bases. Strong bases such as lithium diisopropylamino (LDA) convert ketones to enolides at low temperatures (such as -78 ° C) in an anhydrous environment. Subsequently, the alkenolide is reacted with a bromine-containing alkenylation reagent. The structure of the bromine-containing alkenylation reagent needs to be precisely designed to ensure that the bromine atom and alkenyl group are correctly connected to the target molecule. After the reaction, appropriate post-processing, such as extraction, column chromatography, etc., can obtain the product.
    Third, the hydration and halogenation of alkynes are used. First, alkynes are used as starting materials, and through hydration reaction, in the presence of catalysts such as mercury salts, alkynes are converted into alkenolic structures, which are then rearranged into carbonyl compounds. After that, the obtained product is halogenated, and bromine atoms are selectively introduced at suitable positions, and another double bond is formed to synthesize 5-bromo-2,3-dienepentanone. In this process, the control of the conditions of the hydration reaction and the selectivity of the halogenation reaction are the key, and the reaction temperature, reagent dosage and other factors need to be strictly controlled.
    The above synthesis methods have their own advantages and disadvantages. In practical application, the optimal synthesis path is selected according to the availability of raw materials, the ease of control of the reaction conditions, the yield and purity of the product.
    What should be paid attention to when storing and transporting 5-bromo-2,3-difluoropyridine?
    When storing and transporting 5-bromo-2,3-dihydropyridine, the following matters should be paid attention to:
    First, the storage place must be selected in a cool, dry and well-ventilated place. This is because the substance is quite sensitive to temperature and humidity, and high temperature and humid environment can easily cause it to deteriorate. If it is exposed to high temperature, it may cause a chemical reaction to cause the composition to change; in case of moisture, or deliquescence, etc., its quality will be damaged.
    Second, when storing, it must be stored separately from oxidants, acids, bases, etc., and must not be mixed. The chemical properties of 5-bromo-2,3-dihydropyridine are active, and contact with the above-mentioned substances can easily trigger violent chemical reactions, or cause fires, explosions and other dangerous things.
    Third, during transportation, the packaging must be solid and tight. Use suitable packaging materials, such as sturdy barrels, cans, etc., to prevent the packaging from being damaged due to bumps and collisions during transportation and causing material leakage.
    Fourth, the transportation vehicle also needs to be carefully selected, and it should have corresponding safety protection facilities and emergency treatment equipment. Once there is an accident such as leakage on the way, it can be properly disposed of in time. And the transportation personnel must be professionally trained and familiar with the characteristics of the substance and emergency treatment methods.
    Fifth, whether it is stored or transported, it is necessary to strictly follow relevant laws and regulations and safety standards. Make detailed records, such as storage quantity, warehousing time, transportation route, etc., for supervision and traceability. In this way, we must ensure the safety of 5-bromo-2,3-dihydropyridine during storage and transportation.