Pyridine, 5-bromo-2-(1H-tetrazol-5-yl)-

5-Bromo-2- (1H-tetrazolium-5-yl) pyridine, this is an organic compound. Its chemical properties are unique and interesting.
Let's talk about its structure first. The pyridine ring is aromatic, the electron cloud is evenly distributed and the properties are stable. Bromine atoms are connected to the pyridine ring. Due to the strong electronegativity of bromine, it will absorb electrons, resulting in a decrease in the electron cloud density of the pyridine ring and a change in activity. In the electrophilic substitution reaction, the electron cloud density of the adjacent and para-position of the bromine atom is relatively high, and the electrophilic reagents are easy to attack these positions.
Tetrazolyl is connected to the pyridine ring. Tetrazolyl has multiple nitrogen atoms, and nitrogen has lone pairs of electrons, which can participate in a variety of reactions. In some reactions, tetrazolyl can be used as an electron donor to complex with metal ions to form stable complexes, showing unique coordination chemical properties.
From the perspective of acidity and alkalinity, the nitrogen atom of the pyridine ring has lone pairs of electrons and has a certain alkalinity; the nitrogen atom of the tetrazolyl ring can bind protons and release protons, and has both acid and base. Under different acid and base conditions, the compound exists in the form of different ions, which affects its solubility and reactivity.
In terms of solubility, due to the presence of polar groups, it has a certain solubility in polar solvents such as methanol and ethanol, but poor solubility in non-polar solvents.
Thermal stability is also worth mentioning. It is usually stable within a certain temperature range. At high temperatures, the vibration of chemical bonds intensifies, which may trigger decomposition reactions and generate small molecule substances.
In terms of chemical reactivity, nucleophilic substitution can occur, and bromine atoms can be replaced by nucleophilic reagents; it can participate in cyclization reactions to build more complex cyclic structures; and it can also perform oxidation-reduction reactions to change the oxidation state of pyridine rings and tetrazolyl. This compound is rich in chemical properties and has great application potential in organic synthesis, medicinal chemistry and other fields, providing a broad space for the creation and research of new substances.

5-Bromo-2- (1H-tetrazole-5-yl) pyridine, an organic compound, has important uses in many fields.
In the field of medicinal chemistry, it can be used as a key intermediate. The gentetrazole group has similar spatial and electronic properties to carboxyl bioelectrons, which can improve the metabolic stability, lipophilicity and binding ability of drug molecules. The bromine atom of 5-bromo-2- (1H-tetrazole-5-yl) pyridine has high activity, and can introduce various functional groups through substitution reaction to construct complex drug molecules. For example, it can react with nucleophiles containing amino groups and hydroxyl groups to generate compounds with potential biological activities, which can be used to develop antibacterial, anti-tumor, anti-inflammatory and other drugs.
In the field of materials science, this compound also has extraordinary performance. Tetrazole groups can coordinate with metal ions to form metal-organic framework (MOFs) materials. 5-Bromo-2- (1H-tetrazole-5-yl) pyridine can impart novel properties to MOFs materials due to its unique structure. Its bromine atoms can participate in further modification, changing the pore structure and surface properties of materials, so that such materials have excellent properties in gas adsorption, separation, catalysis, etc. For example, in the field of gas adsorption, it has high selectivity and adsorption capacity for specific gas molecules; in the field of catalysis, it can be used as a high-efficiency catalyst to accelerate the process of specific chemical reactions.
Furthermore, in the field of organic synthetic chemistry, 5-bromo-2 - (1H-tetrazole-5-yl) pyridine is an important synthetic building block. Bromine atoms and tetrazolyl can participate in different types of reactions, such as arylation and alkylation of bromine, cyclization and addition of tetrazolyl. By rationally designing the reaction route, it can be used to synthesize a series of organic compounds with unique structures and specific functions, providing a rich material basis and various synthesis strategies for the development of organic synthetic chemistry.

The synthesis method of 5-bromo-2- (1H-tetrazolium-5-yl) pyridine is not directly stated in the ancient book "Tiangong Kaiwu", but the scientific wisdom and chemical concept contained in it can be used to deduce modern organic synthesis methods.
To synthesize this substance, the first consideration should be the selection of reactants. 5-bromo-2-pyridine formaldehyde and sodium azide can be selected as starting materials. Under suitable reaction conditions, the two are expected to be cyclized to obtain the target product. Among them, 5-bromo-2-pyridyl formaldehyde has an active aldehyde group, and sodium azide is the key reagent for introducing tetrazole ring.
The reaction conditions are also crucial. In organic solvents, such as N, N-dimethylformamide (DMF), due to its good solubility and polarity, it can help the reactants to fully mix and react. The reaction temperature should be controlled in a moderate range of about 80-100 ° C. This temperature can not only promote the reaction rate, but also avoid the excessive occurrence of side reactions. During the reaction, inert gas protection, such as nitrogen, is required to prevent the oxidation of the reactants and ensure the purity of the reaction system.
The reaction process needs to be controlled by monitoring means. The method of thin layer chromatography (TLC) can be used to observe the consumption of reactants and the generation of products at regular points to show the progress of the reaction. After the reaction is completed, the separation and purification of the products is also a priority. The method of recoverable column chromatography selects suitable silica gel as the stationary phase, and elutes with different proportions of eluents, such as petroleum ether and ethyl acetate mixture, to obtain pure 5-bromo-2 - (1H-tetrazole-5-yl) pyridine.
The way of synthesis, as advocated in "Tiangong Kaiwu", requires detailed observation of physical properties and good use of conditions in order to make the reaction smooth and obtain pure products, which adds to the industry of organic synthesis.

5-Bromo-2 - (1H-tetrazole-5-yl) pyridine, this substance is in the market, its price is difficult to determine. The change in its price depends on many reasons.
The first is the cost of production, which is very involved. If the method of making it is difficult, the materials used are rare, it requires fine tools and good agents, and it takes time, the cost will be high, and the price will be high. Like the ancient alchemy, if you want to get a pill, all kinds of rare medicines, it takes a long time, and the price of the pill you have made is more than a thousand gold. Today's product, if it is not easy to make, is also the same.
Furthermore, the trend of supply and demand determines its price. There are many people in the market who want it, but there are few people who produce it, so the price must rise; if the supply exceeds the demand, the price will naturally decline. Just like grain in a prosperous year, the warehouse is full, and the price is flat; in a famine, the grain is scarce, and those who want it are rushing, and the price is several times higher. If this product is used in pharmaceutical research and development, etc., the demand is like a cloud, but the production cannot be met, and the price must be high.
There are also market regulations and business strategies, which are all variables. Different businesses have different prices. Big merchants and giants may have benefits from scale, and the price may be slightly flat; small merchants and hawkers, the cost is slightly higher, and the price may rise. And the taxes and freight in various places also make the price different. Like the ancient goods, the merchants were thousands of miles away, and the road was blocked and long. The freight was added to the price of the goods, and the price in different places was different from the place of origin.
To know the exact price, you need to carefully observe the market conditions, consult the merchants, and compare the similarities and differences. However, the market conditions are ever-changing, and the price is also impermanent, or it can rise and fall from time to time, so you can't be inhibited.

5-Bromo-2 - (1H-tetrazolium-5-yl) pyridine is an organic compound. During storage and transportation, many points need to be paid attention to.
Primary storage environment. When placed in a cool, dry and well-ventilated place, it is easy to deteriorate due to humid air or high temperature. If it is damp or triggers a chemical reaction, its purity will be reduced; under high temperature, it may accelerate decomposition and damage its chemical properties.
Secondary and packaging. It needs to be packed in a sealed package to prevent contact with air, moisture, etc. Sealed packaging can block external interference and ensure its stability. Packing with suitable materials, such as glass bottles or specific plastic containers, depending on their chemical properties, to avoid reactions between packaging materials and compounds.
When transporting, also ensure that the temperature is moderate to avoid violent vibration and collision. Abnormal temperature or cause chemical changes, vibration and collision or damage to the package, resulting in compound leakage. During transportation, it is also necessary to operate in strict accordance with relevant regulations and standards, and be equipped with necessary protective and emergency measures to prevent accidents.
In summary, the storage and transportation of 5-bromo-2 - (1H-tetrazolium-5-yl) pyridine must be careful with the environment, packaging, temperature and transportation specifications, etc., so as to ensure its quality and safety.