Pyridine 4 Fluoro 2 Methyl
pyridine pyrrole pyrazine piperidine piperazine

pyridine, 4-fluoro-2-methyl-

    Specifications

    HS Code

    269099

    Chemical Formula C6H6FN
    Molecular Weight 111.117 g/mol
    Appearance liquid (predicted)
    Boiling Point 159 - 160 °C at 760 mmHg (predicted)
    Density 1.096 g/cm³ (predicted)
    Vapor Pressure 1.18 mmHg at 25 °C (predicted)
    Logp 1.41 (predicted)
    Flash Point 50.59 °C (predicted)
    Solubility In Water Slightly soluble

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    Frequently Asked Questions

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    What are the chemical properties of 4-fluoro-2-methylpyridine?
    4-Jiang-2-methylpyridine is an organic compound with unique chemical properties and important uses in many chemical reactions and industrial production fields.
    This compound is alkaline. Because the nitrogen atom has an unshared electron pair and can accept protons, it can react with acids to form corresponding salts. In case of hydrochloric acid, hydrochloric acid salts will be formed, which makes it useful in some acid-base neutralization reactions and in the preparation of specific catalysts.
    4-Jiang-2-methylpyridine can also participate in nucleophilic substitution reactions. The carbon atoms on the pyridine ring are partially positively charged due to the electronegativity of the nitrogen atom, which makes them vulnerable to attack by nucleophiles. For example, if suitable nucleophiles, such as alcohols and amines, come into contact with them, the active atoms in the nucleophiles can replace the atoms or groups at specific positions on the pyridine ring, and then generate new organic compounds. This process is of great significance in the field of organic synthesis, which can help to build more complex organic molecules.
    In addition, the compound also has performance in oxidation reactions. Under the action of appropriate oxidants, the methyl groups on the pyridine ring can be oxidized, or the electron cloud structure of the pyridine ring itself will be changed, resulting in different oxidation products, laying the foundation for the synthesis of organic materials with special functions.
    The chemical properties of 4-Jiang-2-methylpyridine are rich and diverse, providing a key material basis and reaction pathway for the research and production of organic synthesis, materials science and many other fields.
    What are the common application fields of 4-fluoro-2-methylpyridine
    4-Alkynyl-2-methylpyridine is an organic compound that has a wide range of applications in many fields. The following are its common applications:
    1. ** Medicinal Chemistry **: The alkynyl and pyridine structures of this compound make it a key building block for the construction of drug molecules. Pyridine rings are commonly found in many drug structures and can provide basic centers, which help to interact with biological targets; alkynyl groups can participate in a variety of chemical reactions, such as click chemistry, to connect different pharmacoactive groups, so as to develop new therapeutic drugs. For example, in the development of anti-cancer drugs, the introduction of 4-alkynyl-2-methylpyridine structures can enhance the targeting and affinity of drugs to cancer cells, and improve the anti-cancer effect.
    2. ** Material Science **: In the field of organic optoelectronic materials, 4-alkyne-2-methylpyridine can participate in the polymerization reaction as a functional monomer to prepare polymer materials with specific optoelectronic properties. Its structure can adjust the electron cloud distribution and conjugation degree of molecules, which in turn affect the properties of light absorption, fluorescence emission and charge transport of materials. For example, it is used to prepare organic Light Emitting Diode (OLED) materials to improve their luminous efficiency and stability; or it is used to prepare solar cell materials to improve the capture and conversion efficiency of light energy.
    3. ** Organic Synthesis **: As an important synthesis intermediate, the alkynyl group of 4-alkyne-2-methylpyridine can undergo various chemical reactions with the pyridine ring, such as nucleophilic substitution, electrophilic substitution, and metal-catalyzed coupling reactions. Through these reactions, complex organic compounds can be constructed, providing organic synthesis chemists with a variety of synthesis strategies for the synthesis of natural products, new organic functional molecules, etc.
    4. ** Coordination Chemistry **: The nitrogen atom on the pyridine ring can be used as a ligand to coordinate with metal ions to form metal complexes. These complexes have shown unique properties and applications in the fields of catalysis, molecular recognition, and materials science. For example, in catalytic reactions, metal complexes derived from 4-alkyne-2-methylpyridine can be used as efficient catalysts to catalyze various organic reactions, exhibiting high activity and selectivity.
    What are the synthesis methods of 4-fluoro-2-methylpyridine?
    To prepare 4-ene-2-methylpentane, it can be obtained by the following methods.
    First, 2-methyl-2-pentene is used as the raw material and catalyzed by hydrogenation. This reaction requires the selection of a suitable catalyst, such as palladium, platinum or nickel, etc. Under appropriate temperature and pressure, hydrogen is introduced, and the ethylene bond can be hydrosaturated to obtain the target product 4-ene-2-methylpentane. The reaction is mild and the product purity is quite high.
    Second, 2-methyl-3-pentanol is used as the starting material to dehydrate to form an ethylene first, and then hydrogenated. Under the action of concentrated sulfuric acid and other dehydrating agents, 2-methyl-3-pentanol is heated to eliminate and generate a mixture of 2-methyl-2-pentene and 2-methyl-1-pentene. After separating 2-methyl-2-pentene, 4-ene-2-methylpentane can be obtained according to the above catalytic hydrogenation method. This path step is slightly complicated, but the raw materials may be easier to obtain.
    Third, using 2-methyl-3-bromopentane as raw material, in the ethanol solution of strong bases such as sodium ethanol, heating occurs to eliminate the reaction, and 2-methyl-2-pentene can be obtained. Subsequent catalytic hydrogenation is also used to obtain 4-ene-2-methylpentane. The key to this reaction is to control the reaction conditions so that the elimination reaction can proceed smoothly and minimize side reactions. < Br >
    Or using isoprene and propylene as raw materials, through diene addition (that is, Diels-Alder reaction), a bridged ring compound can be obtained first, and then after appropriate reduction to open the ring, 4-ene-2-methylpentane is also expected to be obtained. However, this reaction condition may be more harsh, requiring specific reaction environments and reagents, and the steps are complicated, which requires very high operation.
    All kinds of production methods have advantages and disadvantages. In actual selection, it is necessary to comprehensively consider the availability of raw materials, cost, reaction conditions and product purity and other factors. After weighing, choose the best method.
    What are the precautions for 4-fluoro-2-methylpyridine during storage and transportation?
    4-N-2-methyl has many points to be paid attention to during storage and transportation.
    When storing, the first environment should be selected. This substance should be stored in a cool and well-ventilated place, away from fire and heat sources. Due to its nature or relatively active, high temperature environments are prone to accidents, so the temperature needs to be strictly controlled, and it is generally recommended to keep it in a specific low temperature range. Furthermore, the storage place should be dry to avoid moisture intrusion, because it may react with water, resulting in quality damage or even danger. And it should be stored separately from oxidants, acids, etc., and must not be mixed to prevent interaction and induce violent reactions.
    During transportation, the packaging must be solid and tight. Appropriate packaging materials must be used in accordance with relevant regulations to ensure that no leakage is caused during transportation bumps. Transportation vehicles must also meet safety standards and be equipped with corresponding emergency treatment equipment and protective equipment. During transportation, environmental factors such as temperature and humidity should be monitored at all times to prevent changes in external conditions from having an adverse impact on them. Route planning should also not be ignored. It should avoid densely populated areas and environmentally sensitive areas to reduce the hazards that may be caused in the event of an accident. At the same time, transportation personnel must be professionally trained, familiar with the characteristics of the substance and emergency treatment methods. In the event of an emergency, they can respond quickly and properly to ensure the safety of the transportation process.
    What are the effects of 4-fluoro-2-methylpyridine on the environment and human health?
    4-Hydrocarbon-2-methylpyridine, which has an impact on both the environment and human health.
    In terms of the environment, if 4-hydrocarbon-2-methylpyridine is released into the atmosphere, it will affect air quality through photochemical reactions. It can react with active substances such as hydroxyl radicals in the air to generate secondary pollutants such as ozone, which in turn affects atmospheric chemical processes, resulting in a decrease in air quality and may also have an effect on regional and even global climate. If it flows into water bodies, it may remain and migrate in water bodies because of its water solubility and chemical stability. Some aquatic organisms may be sensitive to them, causing their physiological functions and reproduction to be affected, which in turn destroys the balance of aquatic ecosystems and interferes with the normal operation of the food chain. After entering the soil, it may be adsorbed by soil particles, affecting the activities of soil microorganisms and soil enzymes, changing the physical and chemical properties of the soil, and having an indirect effect on plant growth and development.
    As for human health, 4-hydrocarbon-2-methylpyridine is irritating. If a person inhales air containing this substance, it will irritate the respiratory mucosa, or cause symptoms such as cough, asthma, and poor breathing. Long-term exposure may increase the risk of respiratory diseases. If skin contact, it may cause skin allergies, redness, swelling, itching, etc. If ingested carelessly, it can irritate the digestive system, causing nausea, vomiting, abdominal pain and other symptoms. Moreover, animal experiments have shown that long-term exposure to this substance may cause chronic damage to the human nervous system, liver, kidney and other organs, affecting its normal function. Some studies also suggest that it may be potentially carcinogenic. Although the evidence of direct carcinogenicity in humans is not sufficient, its latent risk should not be underestimated.