PYRIDINE-4-CARBOXAMIDE OXIME

Pyridine-4-formamidoxime, this is an organic compound. Its chemical structure can be analyzed as follows:
The pyridine ring is a nitrogen-containing hexamembered heterocycle with aromatic properties. At the 4th position of the pyridine ring, there is a formamido group, that is, a -CONH 2 group, which is formed by connecting a carbonyl group (C = O) with an amino group (-NH 2). The formamido group has a certain polarity and can participate in a variety of chemical reactions, such as the hydrolysis and condensation of amides.
Furthermore, the structural feature of "oxime" is that it contains a = N-OH group. In pyridine-4-formamidoxime, the oxime group is attached to a specific position of pyridine-4-formamide, and usually forms a carbonyl oxime structure, that is, it is connected to the carbonyl group of the 4-formamido group of the pyridine ring to form the structure of -C (= N-OH) NH ².
oxime compounds often have unique chemical properties, such as complexing with metal ions, can be used as intermediates in organic synthesis, and participate in many reactions to construct more complex organic structures. Pyridine-4-formamidoxime may have potential applications in medicinal chemistry, materials science and other fields due to the synergistic effect of pyridine ring, formamido group and oxime group.

The physical properties of pyridine-4-formamoxime are particularly important. Looking at it, this substance is mostly in a white crystalline state at room temperature, with a fine texture, like frost. Its melting point is quite impressive, about [X] ° C, just like when a rock is on fire, it needs to reach a specific heat before it melts.
In addition, its solubility also has characteristics. In water, pyridine-4-formamoxime is slightly dissolved. Although it is not emulsified with water, it can also be integrated a little, just like gold infiltration in sand. In organic solvents, such as ethanol and acetone, its solubility is better, and it can dissolve with it more smoothly, just like fish entering water and blending freely. < Br >
Its density is also an important physical property, about [X] g/cm ³, the texture is moderate, not as light as a feather, nor as heavy as a stone. In addition, the smell of this thing is light but not strong, if there is no, it is like the faint fragrance of flowers coming from a distance, you need to smell it carefully.
Its appearance is white and pure, just like the first snow in winter, without variegated infection. Such physical properties are crucial in various fields such as chemical industry and medicine, laying the foundation for subsequent research and application.

There are various ways to prepare pyridine-4-formamoxime. One of the common ones is to start with pyridine-4-formamoxime, so that it reacts with ammonia to obtain pyridine-4-formamide. Next, with a suitable oximizing agent, such as hydroxylamine hydrochloride, under the catalysis of a base, pyridine-4-formamoxime is converted to pyridine-4-formamoxime. In this pathway, the reaction temperature, pressure and reaction time of pyridine-4-carboxylic acid with ammonia need to be controlled to promote the smooth reaction and obtain a good yield of pyridine-4-carboxylamide. In the subsequent oximization step, the type and dosage of bases and the ratio of oximization reagents are all key, which are related to the purity and yield of the product.
Furthermore, or starting from pyridine, carboxyl groups can be introduced first, then amidated, and finally oximized. Pyridine can be converted into pyridine-4-carboxylic acid by specific oxidation methods, and the choice of oxidation reagents is very important, which affects the selectivity and efficiency of the reaction. The process of subsequent amidation and oximization is similar to the previous method, but the conditions of each step also need to be precisely regulated.
There are other compounds with pyridine structure as the starting material, and the preparation of pyridine-4-formamoxime can also be achieved through a series of functional group conversion. However, all these methods need to carefully consider the reaction conditions, such as temperature, solvent properties, catalyst efficiency, etc., in order to make the reaction efficient and the product pure, suitable for different needs and scenarios.

The method of preparing PYRIDINE-4-CARBOXAMIDE + OXIME has been described throughout the ages. One of the common methods is to use PYRIDINE-4-CARBOXAMIDE as the starting material and add an oximizing agent, such as hydroxylamine hydrochloride, to a suitable reaction system. Pyridine-4-formamide and an appropriate amount of hydroxylamine hydrochloride are placed in an organic solvent, such as ethanol, methanol, etc., and then supplemented with alkalis, such as sodium carbonate and sodium hydroxide, to adjust the pH of the reaction and promote the smooth progress of the oximization reaction. When reacting, it is necessary to pay attention to the control of temperature. Generally, under moderate heating conditions, the reaction system is maintained at a certain temperature range, such as between 50 and 80 degrees Celsius, and stirred continuously. After a few hours, pyridine-4-formamoxime can be obtained.
In addition, there are also those who use pyridine-4-nitrile as raw materials. First hydrolyze pyridine-4-nitrile to convert it into pyridine-4-formamide. This hydrolysis step can be hydrolyzed by acid or alkali hydrolysis. For acid hydrolysis, strong acids such as sulfuric acid and hydrochloric acid are commonly used; alkali hydrolysis is made of strong bases such as sodium hydroxide and potassium hydroxide. After the formation of pyridine-4-formamide, pyridine-4-formamide oxime is prepared by reacting with the oximation reagent according to the above-mentioned oximation method.
In addition, pyridine derivatives are used as starting materials, and the structure of pyridine-4-formamide is first constructed through multi-step reaction, and then the target product is prepared by oximation reaction. Although this approach is slightly complicated, it is also a feasible method under specific needs and conditions. During the preparation process, the reaction conditions, such as temperature, pH, and the ratio of reactants, must be precisely controlled in each step to obtain high yield and purity of pyridine-4-formamide oxime.

When using pyridine-4-formamoxime, many matters need to be paid attention to.
First, it is related to its chemical properties. Pyridine-4-formamoxime has specific chemical activity and is very easy to react with other chemical substances. When using, be sure to know its compatibility with surrounding substances. For example, if it encounters a strong oxidant, it may cause a violent reaction, or even the risk of explosion. Therefore, when storing and using, avoid contact with such dangerous substances.
Second, safety. This substance may be toxic and irritating. When operating, appropriate protective measures must be taken. For example, wear protective gloves to prevent skin contact. If the skin is accidentally contaminated, rinse with plenty of water immediately. Wear goggles to protect the eyes from damage. Operate with good ventilation to prevent inhalation of its volatile gas. If inhaled, go to a fresh place in the air as soon as possible.
Third, control the precise dosage. In various experimental or industrial applications, the dosage of pyridine-4-formamide oxime has a great impact on the reaction process and results. Too little dosage or incomplete reaction cannot achieve the desired effect; too much dosage or side reactions will increase the cost and reduce the purity of the product. Therefore, accurate calculation and testing are required before use to determine the appropriate dosage. < Br >
Fourth, proper storage conditions. It should be stored in a dry, cool and ventilated place, away from fire and heat sources. Due to its active chemical properties, improper storage conditions or deterioration may reduce its efficacy. If the storage environment is humid, or it causes moisture degradation, it will affect its quality.