pyridine-4-carbothioamide

Pyridine-4-carbothioamide is a class of organic compounds with unique characteristics. In its molecular structure, the pyridine ring and the thioamide group are connected to each other, and this unique structure endows the compound with many specific chemical properties.
In terms of its physical properties, pyridine-4-carbothioamide is usually solid, and its melting and boiling point is affected by intermolecular forces. The hydrogen bonds and van der Waals forces in the molecule make its melting and boiling point relatively considerable. At the same time, in view of the polarity of its molecules, it exhibits a certain solubility in common organic solvents such as ethanol and dichloromethane.
When it comes to chemical properties, its reactivity is first discussed. The sulfur atom in the amide group is rich in lone pair electrons and has significant nucleophilicity, which can participate in a variety of nucleophilic substitution reactions. When encountering electrophilic reagents, sulfur atoms will attack first and form new chemical bonds. For example, when encountering halogenated hydrocarbons, nucleophilic substitution can occur, and halogenated atoms are replaced by thioamide groups, thereby derived new sulfur-containing compounds.
The pyridine ring also has a profound impact on the chemical properties of the compound. Pyridine rings are weakly basic, and nitrogen atoms can accept protons, which will protonate in acidic media. This property allows pyridine-4-carbon thioamides to exhibit different reactivity in acid-base environments. Under certain conditions, the pyridine ring can also participate in the electrophilic substitution reaction on the ring, and the substituent is introduced at a specific position on the ring to expand the derivatization possibility of the compound.
In addition, the carbon-sulfur double bond in the pyridine-4-carbothioamide can participate in the reduction reaction. Under the action of an appropriate reducing agent, the carbon-sulfur double bond can be reduced to a carbon-sulfur single bond, whereby sulfur-containing derivatives with different structures can be prepared.
In the field of organic synthesis, pyridine-4-carbothioamide, as a key intermediate, can be used to construct complex organic molecules with its diverse reactivity, making great contributions to the development of organic synthetic chemistry.

The common synthesis methods of pyridine-4-carbothioamide are as follows:
First, pyridine-4-carboxylic acid is used as the starting material. First, pyridine-4-carboxylic acid is reacted with dichlorosulfoxide. This step aims to convert the carboxyl group into an acyl chloride to generate pyridine-4-carboxylic chloride. During the reaction, pyridine-4-formic acid is placed in a suitable reaction vessel, an appropriate amount of dichlorosulfoxide is added, and a little catalyst such as N, N-dimethylformamide (DMF) can be added, heated and stirred to promote the smooth progress of the reaction. This reaction is relatively rapid and the yield is quite high. Then, pyridine-4-formyl chloride is reacted with thioamidation reagents (such as potassium thiocyanate and amine compounds), and in a suitable solvent (such as ethanol or acetonitrile), the temperature and reaction time are controlled to cause the nucleophilic substitution reaction between the acid chloride group and the thioamidation reagent, and finally pyridine-4-thioformamide is formed.
Second, pyridine-4-nitrile is used as raw material. First, pyridine-4-nitrile is reacted with a vulcanizing reagent (such as hydrogen sulfide or sodium hydrosulfide) under alkaline conditions to realize the conversion of the nitrile group to the thioamide group. During the reaction, pyridine-4-nitrile is dissolved in a suitable organic solvent (such as tetrahydrofuran or dioxane), a vulcanizing reagent and a base (such as sodium hydroxide or potassium hydroxide) are added, and the reaction is heated and stirred to make the reaction fully proceed. This reaction condition needs to be carefully controlled. Due to the strong alkalinity or the long reaction time, side reactions may be triggered, which will affect the purity and yield of the product. After the reaction, high-purity pyridine-4-thioformamide can be obtained through a series of post-processing operations, such as extraction, washing, drying, column chromatography separation, etc.
Third, it is synthesized by coupling reaction catalyzed by transition metals. The coupling reaction occurs in a suitable solvent in the presence of transition metal catalysts (such as palladium catalysts), ligands and bases. In the reaction, the transition metal catalyst and the ligand form an active catalytic center, which prompts the carbon-sulfur bond coupling of the halide and the thioamide-based reagent to form the target product pyridine-4-thioformamide. This method has high selectivity, but the catalyst cost is high, the reaction conditions are relatively harsh, and the reaction equipment and operation requirements are strict.

Pyridine-4-carbothioamide, which is used in many fields. In the field of medicinal chemistry, it is often a key synthetic block for the creation of various bioactive compounds. Because it contains specific thioamide functional groups, it can interact with specific targets in organisms, so it is often used to develop antibacterial, antitumor and antiviral drugs.
In the field of materials science, pyridine-4-carbothioamide can participate in the preparation of special functional materials. By reacting with other compounds, it can impart unique electrical, optical or mechanical properties to materials, such as the preparation of porous materials with specific adsorption or catalytic properties.
In the field of organic synthesis, pyridine-4-carbothioamide is a very useful reagent. Due to its unique structure, it can participate in a variety of organic reactions, such as nucleophilic substitution, cyclization, etc., to help synthesize complex organic molecules, providing rich strategies and paths for organic synthesis chemists.
In agricultural chemistry, pesticides or plant growth regulators may be developed based on this. With its special chemical properties, it can achieve the control of pests and diseases or the regulation of plant growth and development, so as to improve crop yield and quality.
It can be seen that pyridine-4-carbon thioamide has important application value in many fields such as medicine, materials, organic synthesis and agricultural chemistry, and plays a key role in promoting the development of various fields.

Pyridine-4-carbothioamide is an important compound in the field of organic chemistry. It has unique physical properties, so let me tell you in detail.
Looking at its appearance, under room temperature and pressure, pyridine-4-carbothioamide is often in the state of white to light yellow crystalline powder, which makes it easy to distinguish among many substances. Its texture is delicate, like the first snow in winter, sprinkling in the container.
As for the melting point, the melting point of pyridine-4-carbothioamide is quite significant, about 150-155 ℃. When the temperature gradually rises, this compound melts like ice in the spring sun, slowly turning from solid to liquid. The characteristics of melting point are of great significance in the purification and identification of compounds in experimental operations, just like a navigator's compass, guiding the direction of experiments.
In terms of solubility, pyridine-4-carbothiamide is slightly soluble in water. Water is the source of life, but before this compound, the fusion of the two is slightly stingy. However, it has good solubility in common organic solvents such as ethanol and dichloromethane. Like a fish in water, it can be evenly dispersed in these organic solvents. This property provides many conveniences in organic synthesis reactions and allows the reaction to proceed more smoothly.
In addition, the stability of pyridine-4-carbothioamide also needs attention. Under normal storage conditions, in a dry and cool place, it can maintain a relatively stable state. However, if it encounters strong oxidizing agents, strong acids or strong bases, it will encounter strong enemies, and its structure may change and its properties will also change.
In short, the physical properties of pyridine-4-carbothioamide play a key role in many fields such as organic synthesis and drug development, illuminating the path of scientific research and guiding the way forward.

Pyridine-4-carbon thioamide, the price of this product in the market is difficult to set. The price of the cover often changes due to various reasons such as current situation, supply and demand, and origin.
Looking at the past, when the market situation is stable, its price may vary according to quality and purity. If it is a high-purity product, the price must be expensive, or between a few gold per gram and tens of gold. However, if the purity is slightly lower, the price will drop slightly, ranging from a few cents per gram to a few gold.
When the world situation changes and supply and demand are out of balance, the price also moves greatly. If there are many people who want it, but there are few people who produce it, the price will soar, several times higher than usual. On the contrary, if the supply exceeds the demand, the price will plummet, falling to half of the usual, or even lower.
Furthermore, the difference in origin is also related to its price. If it is shipped from a distance, the fare will be superimposed, and the price will be high; if it is produced locally, the freight will be omitted, and the price will be cheaper.
If you want to know the price of pyridine-4-carbon thioamide in the market, you must consult pharmaceutical companies and chemical raw material manufacturers in person, and depending on the current situation, you can get a more accurate number. It is difficult to hide it.