pyridine-4-carbohydrazide

Pyridine-4-formyl hydrazide, which is one of the organic compounds. This substance has many unique chemical properties.
Structurally, it contains a pyridine ring and a formyl hydrazide group, and this specific structure endows it with a variety of reactivity. The nitrogen atom of the pyridine ring has a lone pair of electrons, which can be used as an electron donor to participate in coordination reactions and can form complexes with metal ions. This property may have important uses in the fields of catalysis and materials science.
In the formyl hydrazide group, the carbonyl group is connected to the hydrazide group, which makes the carbonyl carbon electrophilic and vulnerable to attack by nucleophiles. Nucleophilic substitution reactions can occur, such as the reaction with alcohols to form hydrazone derivatives, which are often used in organic synthesis to construct nitrogen-containing heterocyclic structures.
And formylhydrazide is weakly basic and can react with acids to form salts. In aqueous solution, pyridine-4-formylhydrazide or protonation and deprotonation are balanced, and this acid-base property may affect its stability and reactivity in solution.
In addition, due to the existence of a conjugated system in the molecule, pyridine-4-formylhydrazide has certain photophysical properties, such as absorbing ultraviolet light of specific wavelengths, which may have potential applications in fluorescent materials. Under appropriate conditions, structural transformation may be achieved through reactions such as oxidation and reduction, providing rich possibilities for organic synthesis.

The common synthesis method of pyridine-4-formyl hydrazide, using pyridine-4-carboxylic acid as the starting material. First, pyridine-4-carboxylic acid is co-heated with thionyl chloride, which is an acid chlorination reaction. Sulfoxide chloride has strong chlorination ability. When the two are heated, the carboxyl group of pyridine-4-carboxylic acid is converted into an acyl chloride to obtain pyridine-4-formyl chloride. This step requires attention to the reaction temperature and the amount of thionyl chloride. If the temperature is too high or the amount is too high, it may cause side reactions.
Then, pyridine-4-formyl chloride is reacted with hydrazine hydrate The amino group in hydrazine hydrate has strong nucleophilicity, and it is easy to undergo nucleophilic substitution with the acyl chloride group of pyridine-4-formyl chloride. After this reaction, the acyl chloride group is replaced by hydrazine group to form pyridine-4-formyl hydrazide. This step should be carried out under mild conditions, such as lower temperature and suitable solvent, to improve the purity and yield of the product.
There are also those who use pyridine-4-formate ethyl ester as raw material. Pyridine-4-formate ethyl ester is first reacted with hydrazine hydrate in a suitable solvent, which is a hydrazinolysis reaction of ester. The amino group of hydrazine hydrate attacks the carbonyl carbon of the ester group. Through a series of electron transfer and chemical bond rearrangement, the ester group is converted into an acyl hydrazide group to obtain pyridine-4-formyl hydrazide. In this path, the preparation of pyridine-4-formate ethyl ester may require additional steps, but the reaction conditions are relatively mild and the requirements for reaction equipment are slightly lower.
During the synthesis process, the purity of raw materials, reaction temperature, reaction time, and solvent selection are all key factors. The raw materials are impure, or impurities are introduced, which affects the quality of the product; improper temperature may cause the reaction rate to be too fast or too slow, or even cause side reactions; insufficient reaction time, incomplete product transformation, or decomposition of the product if it is too long; different solvents have different solubility and reactivity of the reactants, which in turn affects the reaction process and results. Therefore, it is necessary to fine-tune the reaction conditions to achieve the ideal synthesis effect.

Pyridine-4-formylhydrazide is useful in various fields. In the field of medicine, it can be used as a raw material for drug synthesis. Because of its specific chemical structure and activity, it can be chemically modified to create compounds with unique pharmacological activities, such as antibacterial, anti-inflammatory and other drugs.
In the field of materials science, pyridine-4-formylhydrazide also has potential uses. It can react with other compounds to prepare functional materials. For example, it can be used to synthesize materials with special adsorption properties, and can play a role in environmental purification, substance separation, etc. Because it can interact with specific substances, it can achieve enrichment and separation of target substances.
Furthermore, in scientific research experiments, pyridine-4-formylhydrazide is often used as a chemical reagent. Researchers use it to participate in various chemical reactions, explore reaction mechanisms, and develop new synthesis paths. Due to its unique chemical properties, it can act as a key intermediate in organic synthesis reactions, help build complex organic molecular structures, and contribute to organic chemistry research.
To sum up, pyridine-4-formylhydrazide has shown important application value in many fields such as medicine, materials science, and scientific research experiments. With the continuous development of science and technology, its application prospects may be broader.

Pyridine-4-formylhydrazide, its physical state is mostly white to pale yellow crystalline powder at room temperature. The melting point of this substance is about 185-189 ° C. Due to the specific hydrazine and pyridine ring structures in the molecule, it has a certain polarity, a certain solubility in water, and is slightly soluble in organic solvents such as ethanol.
Looking at its chemical properties, the nitrogen atom of the hydrazine group in pyridine-4-formylhydrazide is electron-rich and has strong nucleophilicity. In case of acid, it can form salts, which can react with formaldehyde, ketone and other carbonyl-containing compounds to form hydrazone derivatives. This reaction is often used in organic synthesis to construct new carbon-nitrogen bonds and synthesize compounds with specific structures and functions. The presence of the pyridine ring endows it with aromaticity and weak basicity, and can participate in electrophilic substitution reactions under specific conditions. Although the activity is lower than that of the benzene ring, the reaction can be regulated by introducing suitable substituents. Check point and activity.
Pyridine-4-formylhydrazide is used in the field of medicinal chemistry to develop antibacterial and anti-tumor active drugs due to its unique physical and chemical properties; in materials science, it can be used as a ligand to complex with metal ions to prepare functional metal-organic materials; also used in analytical chemistry, as an analytical reagent for qualitative and quantitative detection of specific substances.

Pyridine-4-formylhydrazide, an organic compound, is widely used in scientific research, medicine and other fields. However, its market price often fluctuates due to various factors such as quality, purity, manufacturer, purchase quantity and market supply and demand, and it is difficult to generalize.
Looking at the past, if you buy it in the chemical raw material market, its purity is ordinary, and the price per kilogram may be in the hundreds of yuan. The purity is set to reach the analytical purity level. Due to strict control of impurities and complex production processes, its price may be higher, per kilogram or over 1,000 yuan. If the purchase quantity is small, only a few grams or tens of grams, purchased from the experimental reagent supplier, the price per gram may range from a few yuan to tens of yuan, because it includes packaging, transportation and small retail bonuses.
As for manufacturers purchasing in large quantities, due to the large quantity, they may be able to negotiate with suppliers and get preferential prices, and the price per kilogram may drop significantly. And market supply and demand also affect the price. If demand is strong and supply is small, the price will rise; if the market is saturated and the supply is sufficient, the price may stabilize or fall.
For real-time and accurate market prices, it is advisable to consult chemical raw material suppliers, reagent distributors, or refer to quotations from professional chemical product trading platforms, so as to obtain price information that is close to market conditions.