Pyridine,4-(bromomethyl)-(9CI)

(This substance) 4 - (hydroxymethyl) pyridine (9CI), its chemical properties are quite unique. In this compound, the hydroxymethyl group is connected to the pyridine ring, giving it some special reactivity.
From the perspective of nucleophilic substitution, because the hydroxyl group on the hydroxymethyl group has a certain activity, under suitable conditions, the hydroxyl group can be replaced by other nucleophilic reagents. For example, under basic conditions with halogenated hydrocarbons, nucleophilic substitution reactions can occur to generate ether derivatives. This is because the lone pair electron of the hydroxyl oxygen atom has nucleophilic properties, which can attack the carbon atom of the halogenated hydrocarbon, and the halogen ion leaves as a leaving group.
In terms of oxidation reactions, hydroxymethyl groups are easily oxidized. Mild oxidants can oxidize it to aldehyde groups to generate 4-formylpyridine; if stronger oxidants are used, aldehyde groups will be further oxidized to carboxyl groups, resulting in 4-pyridinecarboxylic acid.
The pyridine ring itself also has its own characteristics. The pyridine ring has a certain aromaticity, and its nitrogen atoms make the electron cloud density distribution on the ring uneven, resulting in differences in the electrophilic substitution activity of the pyridine ring from that of the benzene ring. Generally speaking, the electrophilic substitution reaction mainly occurs at the β-site (relative to the nitrogen atom) of the pyridine ring, because the electron-absorbing effect of the nitrogen atom reduces the electron cloud density of the α-site and γ-site, and the β-site is relatively high, which is more conducive to the attack of electrophilic reagents.
In addition, 4- (hydroxymethyl) pyridine can also be used as a ligand to coordinate with metal ions, using its coordination ability of nitrogen atoms and hydroxyl oxygen atoms to form stable complexes, which have shown potential application value in catalysis, materials science and other fields.

(Cyanomethyl) amine (9CI) is mainly used in the following fields:
One is the field of organic synthesis. In this field, it can be used as a key intermediate. For example, when building complex organic molecular structures, (cyanomethyl) amine (9CI) can participate in various reaction processes due to its unique chemical activity. Taking nucleophilic substitution reactions as an example, the amino groups in the molecule are nucleophilic and can react with substrates such as halogenated hydrocarbons, thereby introducing cyanomethyl groups, which lays the foundation for the subsequent generation of organic compounds with specific structures and functions, and helps chemists synthesize organic materials with novel structures and properties, such as precursors of new drug molecules.
The second is in the field of medicinal chemistry. It has important application value. Due to the structural characteristics of (cyanomethyl) amine (9CI), it can provide a variety of options for the design and synthesis of drug molecules. For example, when developing small molecule drugs with specific pharmacological activities, the introduction of cyanomethyl amine structure into the drug skeleton may change the lipophilicity of the drug and the ability to bind to the target. Through reasonable design and modification, drug molecules based on (cyanomethyl) amine (9CI) may be able to act more efficiently on disease-related targets, providing new drug options for the treatment of diseases, such as anti-tumor, anti-infection and other drug development directions.
The third is in the field of materials science. ( Cyanomethyl) amine (9CI) can participate in the synthesis process of polymer materials. For example, when preparing some functional polymers, it can be used as a monomer or modifier. When participating in the polymerization reaction as a monomer, it can endow the polymer with special chemical properties, such as the introduction of cyanyl groups can enhance the polarity of the polymer, thereby affecting its solubility and thermal stability. If added as a modifier to the existing polymer system, it may improve the surface properties and mechanical properties of the polymer, which will help to develop polymer materials with special properties to meet the special needs of different fields for material properties. For example, it has potential applications in high-performance engineering plastics, advanced composites, etc.

To prepare (cyanomethyl) nonane (9CI), the methods are as follows:
First, it can be prepared by nucleophilic substitution reaction. The halononane and sodium cyanide (NaCN) are heated and stirred in an appropriate solvent (such as dimethyl sulfoxide (DMSO). The halogen atom of halononane is highly active, and the cyanogen ion (CN) has strong nucleophilicity. When the two meet, the halogen atom is replaced by the cyanogen root, and the (cyanomethyl) nonane is obtained. This reaction condition is relatively mild, but the halononane needs to be prepared in advance, and the cyanide is highly toxic. The operation needs to be extremely cautious to prevent leakage and poisoning.
Second, through the Grignard reagent method. First, bromononane is reacted with magnesium chips in anhydrous ethyl ether to make Grignard's reagent nonylmagnesium bromide. Then it is reacted with formaldehyde to obtain nonylmethanol derivatives, then oxidized with a suitable oxidant (such as chromium trioxide-pyridine complex) to form an aldehyde, and finally added with hydrocyanic acid (HCN) to obtain the target product. There are many steps in this process, but the intermediate product is easier to separate and purify, which can better control the reaction process and product purity.
Third, the hydrocyanation of olefins is used. If there are suitable nonyl-containing compounds, they can be added to hydrogen cyanic acid under the action of catalysts (such as some transition metal complexes). This method has a high atomic utilization rate and conforms to the concept of green chemistry. However, it requires strict catalyst requirements and precise control of reaction conditions to ensure the selective addition of olefins to (cyanomethyl) nonane.

(Cyanomethyl) amine (9CI) must pay attention to many key matters during storage and transportation.
First storage environment. It is advisable to choose a dry, cool and well-ventilated place, away from fire and heat sources, because it is easy to cause danger when exposed to open flames and hot topics. It needs to be stored separately from oxidants, acids, etc. to prevent mutual reaction. Because of its active chemical properties, contact with these substances, or cause violent reactions, endangering safety. The storage area should be equipped with suitable containment materials to prevent timely handling in case of leakage.
In terms of transportation, it is necessary to ensure that the packaging is complete and sealed. During transportation, it should be handled with care to avoid collisions and heavy pressure to prevent material leakage due to package damage. Transport vehicles shall be equipped with corresponding fire-fighting equipment and leakage emergency treatment equipment for emergencies. During transportation, they shall be driven according to the prescribed route, and do not stop in densely populated areas and residential areas, so as to reduce the harm to the public in the event of an accident.
When operating, the operator shall be specially trained and strictly abide by the operating procedures. It is recommended that the operator wear a self-priming filter gas mask (full mask), wear a tape gas suit, and wear rubber gloves. Do a good job of personal protection and avoid direct contact. Smoking is strictly prohibited in the workplace. After the operation, it should be thoroughly cleaned. No eating, drinking or smoking is allowed during the work period. < Br >
Storage and transportation of (cyanomethyl) amine (9CI), from environmental selection, packaging and transportation to personnel operation, every step is related to safety and must be strictly controlled.

For (cyanomethyl) alkyne (9CI), what is the market price? This is a chemical substance, and its market price often changes due to various reasons.
First, the difficulty of preparation is different. If the preparation requires complicated methods, the materials used are rare, and the price must be high. The synthesis of (cyanomethyl) alkyne, or involves special reactions, requires delicate control, and the reagents used may also be difficult to obtain. This can cause its preparation cost to increase significantly, and the price will also rise.
Second, purity is related to price. High-purity (cyanomethyl) alkyne, the use may be more specialized, such as for high-end scientific research experiments and special chemical synthesis. If you want to get high purity, the purification technology must be refined, the process is also complicated, the cost rises and the price is high. For low purity, the use may be limited, and the price is slightly lower.
Third, the situation of supply and demand is the main reason. If at some time, the demand for (cyanomethyl) alkyne in the scientific research or industrial sector suddenly increases, and the supply is limited, the price will rise. On the contrary, if the supply exceeds the demand, the price may drop.
Fourth, the competitive situation of the market also has an impact. If there are many manufacturers of this substance and the competition is intense, it is a competition for the market, or there may be a price reduction. However, if there are few manufacturers, it is a monopoly, and the price may be controlled by them.
Overall, the market price of (cyanomethyl) alkyne (9CI) may range from tens to thousands of yuan per gram, but the exact price depends on real-time market conditions and negotiations between buyers and sellers.