Pyridine 3 Trifluoromethyl
pyridine pyrrole pyrazine piperidine piperazine

Pyridine, 3-(trifluoromethyl)-

    Specifications

    HS Code

    849427

    Chemical Formula C6H4F3N
    Molecular Weight 147.097 g/mol
    Appearance Colorless to light yellow liquid
    Boiling Point 106 - 108 °C
    Melting Point -45 °C
    Density 1.25 g/mL at 25 °C
    Vapor Pressure 7.4 hPa at 20 °C
    Flash Point 15 °C
    Solubility In Water Slightly soluble
    Logp 2.37

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    Frequently Asked Questions

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    What are the physical properties of 3- (trifluoromethyl) pyridine?
    Triethylamine has the characteristics of alkali. This substance is weakly alkaline and can combine with acids to form a genus of salts. In case of hydrochloric acid, triethylammonium chloride is produced. Because of the lone pair of electrons on the nitrogen atom, it can hold protons and show alkali properties.
    It is volatile and can slowly dissipate in the air under normal temperature and pressure. And has a special smell, mostly due to irritating odor.
    The solubility of triethylamine also has its own characteristics. It can be soluble in organic solvents such as ethanol and ether, and has a certain solubility in water, but it is not very high.
    In terms of its reactivity, it can be used as a nucleophilic reagent. In many organic reactions, it can interact with electrophilic reagents such as halogenated hydrocarbons to produce substituted products. Such as reacting with halogenated alkanes to obtain quaternary ammonium salts. It can also be used as a catalyst or co-catalyst in some catalytic reactions, which can promote the reaction process and rate.
    In addition, the chemical stability of triethylamine is still good, and it is not easy to decompose spontaneously under normal conditions. However, when encountering strong oxidizing agents, it can initiate oxidation reactions, causing changes in structure and properties. Its physical properties are colorless to light yellow liquids under normal conditions, with a density slightly less than that of water, and flammability. In case of open flames and hot topics, there is a risk of explosion.
    What are the chemical properties of 3- (trifluoromethyl) pyridine?
    Triethylamine has warm and lively properties, and often shows specific properties in various chemical changes.
    Looking at its physical properties, at room temperature, triethylamine is a colorless liquid with a pungent odor, similar to the smell of rotten fish, and its gas is very strong. Its boiling point is quite low, about 89 degrees Celsius, and its melting point is -114.7 degrees Celsius, so it is very volatile and flowing in room temperature environment. It also has a certain solubility, miscible with organic solvents such as alcohols and ethers, but its solubility in water is slightly limited.
    When it comes to chemistry, triethylamine is alkaline, which is its important characteristic. The nitrogen atom contains lone pairs of electrons, which can accept protons in chemical reactions, and can form salts with acids. For example, when it encounters hydrochloric acid, it is synthesized into triethylamine hydrochloride, which is soluble in water. The reaction formula is:\ ((C_ {2} H_ {5}) _ {3} N + HCl\ longrightarrow (C_ {2} H_ {5}) _ {3} NH ^ {+} Cl ^{-}\) 。
    Because of its alkaline nature, triethylamine is often used as an acid binding agent in organic synthesis. In many reactions, if an acid is formed, triethylamine can be combined with it to promote the reaction to proceed in the positive direction. For example, in the esterification reaction, under the catalysis of sulfuric acid, carboxylic acid and alcohol react to form esters, water is formed in the process, and hydrogen ions of sulfuric acid are also present in the system. Triethylamine can combine with hydrogen ions to remove the acid generated by the reaction, so that the equilibrium shifts to the right, and the yield of esters is improved.
    Furthermore, triethyl amines are also quite active in nucleophilic substitution reactions. The lone pair electrons of its nitrogen atom give it nucleophilicity, which can attack compounds with electrophilic centers such as halogenated hydrocarbons, causing substitution reactions to occur. For example, when it encounters bromoethane, the nitrogen atom attacks the carbon atom of bromoethane, and the bromine ion leaves to form tetraethyl ammonium bromide. The reaction is as follows:\ ((C_ {2} H_ {5}) _ {3} N + C_ {2} H_ {5} Br\ longrightarrow (C_ {2} H_ {5}) _ {4} N ^ {+} Br ^{-}\) 。
    In addition, triethyl amines can act as ligands in some metal-catalyzed reactions. Its lone pair electrons can coordinate with metal atoms, affect the electron cloud density and spatial structure of metals, and then adjust the activity and selectivity of catalytic reactions. It is widely used in the field of organic synthetic chemistry.
    What are the main uses of 3- (trifluoromethyl) pyridine?
    The main use of tris (triethylamino) silane is as a reagent commonly used in organic synthesis. It has a wide range of uses in the field of organic synthesis.
    First, it can be used as a silylation reagent. In many organic reactions, the substrate molecule can be introduced into the silicon group. This silicon group can play a variety of roles in the reaction, or it can protect the specific functional group from the influence of the reaction conditions, and then remove it when appropriate; or it can participate in the construction of special molecular structures, and the synthesis of the target product can be achieved through subsequent silicon-related reactions.
    Second, it is also used in the field of materials science. It can be used to prepare materials with special properties, such as modified polymer materials. By reacting with polymer molecules, the surface properties, thermal stability, mechanical properties, etc. of the polymer are changed, and the comprehensive properties of the material are improved to meet the needs of different scenarios.
    Third, in some catalytic reaction systems, tris (triethylamino) silane can be used as an auxiliary agent. It can adjust the activity and selectivity of the catalyst, help the catalytic reaction to proceed more efficiently and selectively, promote the reaction to convert in the desired direction, and improve the yield and purity of the product.
    Fourth, it is also useful in surface modification. It can modify the surface of various materials, imparting new chemical properties and functions to the surface, such as improving the hydrophilicity and biocompatibility of the material surface, and broadening the application range of materials in different fields, such as biomedicine, electronic devices, etc.
    What are the synthesis methods of 3- (trifluoromethyl) pyridine?
    The synthesis of (triethylamino) ethylene has attracted much attention in the field of organic synthesis. Its synthesis methods are diverse, each has its own advantages and disadvantages, and continues to develop with the evolution of chemical technology.
    First, it can be prepared by the nucleophilic substitution reaction of the corresponding halogenated hydrocarbons and triethylamine. The halogen atoms of halogenated hydrocarbons are highly active, and they are easily attacked by the nitrogen atoms in triethylamine to form (triethylamino) ethylene. This method has relatively mild conditions and simple operation. However, the choice of halogenated hydrocarbons needs to meet the reaction requirements, and side reactions may affect the yield.
    Second, it is synthesized by alkenylation reaction. A suitable alkenylation reagent is reacted with triethylamine derivatives, and the alkenyl group is introduced through a specific catalyst and reaction conditions to form the target product. This approach can effectively construct carbon-nitrogen double bonds and is widely used in organic synthesis. However, the choice of catalyst and the precise control of reaction conditions are crucial, which are related to the selectivity and efficiency of the reaction.
    Third, it can also be obtained through the ring-opening reaction of nitrogen-containing heterocyclic compounds. Some nitrogen-containing heterocyclic rings can be opened under specific conditions, and (triethylamino) ethylene can be formed through structural rearrangement. This method can take advantage of the special structure of heterocyclic compounds and provide new ideas for synthesis. However, the preparation and ring-opening conditions of heterocyclic compounds need to be carefully considered to prevent side reactions from occurring.
    In addition, there are also those synthesized by metal-organic chemical methods. Substrate molecules are activated with the help of metal catalysts to promote the reaction. The high activity and selectivity of metal-organic reagents can make the synthesis more efficient and accurate. However, metal catalysts are expensive and post-processed or more complicated, which imposes certain restrictions on industrial production.
    All synthesis methods have their own advantages. In practical applications, chemists need to carefully choose appropriate synthesis strategies according to specific needs, raw material availability, cost considerations and other factors in order to achieve the ideal synthesis effect.
    What are the precautions for using 3- (trifluoromethyl) pyridine?
    "Tiangong Kaiwu" says: "All triethyl, when using it, pay attention to all kinds of things, it is related to the effect, and it must be observed."
    Triethyl This thing, when using it, should first pay attention to its properties. Its sex is lively, and it is prone to violent reactions when exposed to heat, open flames or oxidants, and even the danger of explosion. Therefore, the place used must be prohibited from fire sources and avoid the existence of oxidants. When storing, it should also be placed in a cool and ventilated place, away from fire and heat sources, and tightly sealed to prevent leakage.
    Furthermore, protection is indispensable. Those who handle this thing must wear suitable protective equipment, such as protective clothing, protective gloves and goggles. Because it may be irritating to the skin, eyes and respiratory tract, if you accidentally touch it, rinse it with plenty of water as soon as possible, and seek medical treatment if necessary.
    In addition, the process of use, the operation standard is the key. It is advisable to do it in a well-ventilated place, or borrow ventilation equipment to reduce its concentration in the air. When taking it, operate it with precision, and do not overdose or accidentally touch other things, causing the reaction to get out of control. After use, properly dispose of the residue, do not dump it at will, and discard it in accordance with relevant regulations, so as not to pollute the environment.
    In short, those who use triethyl should be cautious in terms of safety, protection and operation, and pay close attention to it in order to keep it safe and make the best use to avoid its harm.