Pyridine-3-sulfonylchloridehydrochloride

Pyridine-3-sulfonyl chloride hydrochloride is also an organic compound. It is active and has a wide range of uses in the field of organic synthesis.
This compound has strong reactivity, among which the sulfonyl chloride group (-SO 2O Cl) is very easy to hydrolyze in contact with water. When hydrolyzed, the sulfonyl chloride group interacts with water to form sulfonic acid (-SO 2O H) and hydrogen chloride (HCl), which often emits heat. Therefore, when storing and using, it is necessary to avoid water and moisture.
It is often a key reactant in nucleophilic substitution reactions. The chlorine atom of sulfonyl chloride is very active and is easily replaced by various nucleophilic reagents, such as alcohols and amines. When reacting with alcohol, sulfonates can be formed. This reaction is in the organic synthesis path and is an important means to prepare sulfonate compounds with specific structures; when reacting with amines, sulfonamides can be formed. The synthesis of many drugs, pesticides and functional materials often relies on this reaction to build key structures.
Furthermore, the presence of pyridine rings in pyridine-3-sulfonyl chlorohydrochloride imparts weak basicity and certain conjugate system characteristics to the molecule. Pyridine rings can participate in a variety of reactions related to electronic effects, affecting the overall reactivity and selectivity of molecules. And because pyridine rings have certain stability and rigidity, they can provide specific spatial configuration and stability for molecules when building complex organic frameworks. Due to its unique chemical properties, pyridine-3-sulfonyl chloride hydrochloride plays an important role in the field of organic synthetic chemistry and is a key raw material for many fine chemicals and drug research and development.

Pyridine-3-sulfonyl chloride hydrochloride is a commonly used reagent in organic synthesis, and its common uses are quite extensive.
First, in the field of drug synthesis, this reagent plays a significant role. It can be used as a key intermediate to participate in the construction of many drug molecules. For example, in the synthesis path of some antibacterial drugs, pyridine-3-sulfonyl chloride can react with specific nitrogen-containing heterocyclic compounds, and introduce sulfonyl groups into the target molecular structure through clever chemical transformation, thereby endowing the drug with unique biological activity and pharmacological properties and enhancing its antibacterial efficacy.
Second, it also has applications in materials science. For example, it is used to prepare functional polymer materials. With the help of pyridine-3-sulfonyl chloride hydrochloride reacting with polymer monomers containing hydroxyl or amino groups, sulfonyl chloride groups can be introduced into the polymer backbone. After further reaction, these groups can endow polymer materials with special properties such as hydrophilicity and ion exchange, and show good application prospects in ion exchange resins, separation membrane materials, etc.
Third, in the study of organic synthesis methodologies, it is often used as a probe reagent. Researchers use its unique reactivity to explore novel chemical reaction mechanisms and synthesis strategies. For example, studying its reaction kinetics and selectivity with different nucleophiles helps to expand the boundaries of organic synthesis chemistry and provide a basis for the development of more efficient and green synthesis methods.
Fourth, in the field of dye synthesis, pyridine-3-sulfonyl chloride hydrochloride can be used to modify the molecular structure of dyes. By introducing sulfonyl chloride groups, the electron cloud distribution and spatial configuration of dye molecules are changed, and then the color, solubility and dyeing properties of dyes are adjusted to meet the needs of different textile materials and printing and dyeing processes.

The preparation of pyridine-3-sulfonyl chloride hydrochloride is an important step in chemical preparation. Usually, the following steps can be followed.
Start with pyridine-3-sulfonic acid as a raw material. This raw material needs to be of high purity to ensure a smooth reaction. Place pyridine-3-sulfonic acid in a suitable reaction vessel, which should be clean and dry to prevent impurities from affecting the reaction.
Then, slowly add a chlorination reagent to it. Commonly used chlorination reagents such as phosphorus pentachloride ($PCl_ {5} $) or sulfinyl chloride ($SOCl_ {2} $). Taking phosphorus pentachloride as an example, its reaction with pyridine-3-sulfonic acid is quite violent, so when adding it, be careful and slow, and stir it at the same time to make the reaction mix evenly. During the reaction, hydrogen chloride gas will escape, and it needs to be properly handled to prevent pollution of the environment or endanger the safety of operators.
If sulfinyl chloride is used, this reaction is relatively mild. When sulfinyl chloride reacts with pyridine-3-sulfonic acid, pyridine-3-sulfonic chloride, sulfur dioxide and hydrogen chloride are formed. After the reaction is completed, the excess sulfinyl chloride can be removed by distillation or other means.
After the reaction is completed, the resulting product pyridine-3-sulfonyl chloride needs to be further converted into pyridine-3-sulfonyl chloride hydrochloride. At this time, dry hydrogen chloride gas can be introduced into the reaction system. The gas is slowly introduced until the reaction system reaches a saturated state, and then pyridine-3-sulfonyl chloride combines with hydrogen chloride to form pyridine-3-sulfonyl chloride.
Finally, the product is separated and purified. Common methods include recrystallization and filtration. By recrystallization, impurities can be removed and the purity of the product can be improved. Appropriate solvent is selected, the product is dissolved, heated to a certain temperature, and then slowly cooled to crystallize the product. After filtration, drying and other steps, pure pyridine-3-sulfonyl chloride can be obtained.

Pyridine-3-sulfonyl chloride hydrochloride is one of the most characteristic chemical substances. When storing, you need to pay attention to many things.
First, this substance is quite sensitive to moisture. Therefore, the storage place must be kept dry, should be selected in a very low humidity place, and the packaging must be tightly sealed to prevent external moisture intrusion and reaction, resulting in deterioration.
Second, temperature control is also crucial. It should be stored in a cool place, not in a high temperature environment. Due to high temperature, it is easy to cause its chemical properties to change, or cause decomposition, volatilization and other adverse conditions, affecting its quality and performance.
Third, pyridine-3-sulfonyl chlorohydrochloride may be corrosive and toxic to a certain extent. The storage place should be kept away from food, beverages and objects commonly touched by the human body, and should be reasonably separated from other chemical substances to avoid dangerous chemical reactions caused by accidental mixing.
Fourth, the storage area should be well ventilated. In this way, even if the substance is volatile, its volatiles can be discharged in time to reduce the concentration in the air and reduce potential hazards.
Fifth, the name, characteristics, danger warning and other information of the substance should be clearly marked at the storage place. So that relevant personnel are aware of its nature, treat it with caution during operation, and in the event of an emergency, they can quickly take appropriate measures.

What you are asking about is the market price range of pyridine-3-sulfonyl chloride hydrochloride. However, it is not easy to know the price of this product. Because the market is fickle, the price varies with many factors.
Its price may vary depending on the place of origin. If the product is excellent, the materials are easy to collect, the labor cost is saved, and the price may be slightly lower; if the production is remote, the materials are difficult to produce, and the labor cost is complex, the price may be high. And its quality is also the main reason. Those with high purity and few impurities have a wide range of uses. If there are many applicants, the price will be high; if the quality is slightly inferior, the price may drop.
Furthermore, the supply and demand of the market also make the price move. If there are too many applicants and too few suppliers, the price will tend to rise; if the supply exceeds the demand, the price may fall. Looking at the city of the past, the price of such chemical products often fluctuated. And in different seasons, the price also varies. When it is in high demand, the price is often high; when it is in low demand, the price may fall.
Roughly speaking, the price of pyridine-3-sulfonyl chlorohydrochloride is in the market or in the range of tens to hundreds of yuan per kilogram. However, this is only a rough estimate. The actual price still needs to be asked by merchants in various cities or platforms for trading chemical materials.