Pyridine-3-Carbonyl Chloride Hydrochloride

Pyridine-3-formyl chloride hydrochloride is an organic compound with unique chemical properties. Its appearance is often white to yellowish crystalline powder, which is easy to deliquescent in air because of its affinity for water.
From the perspective of reactivity, the acid chloride group in this compound is active. The acid chloride rapidly hydrolyzes in contact with water to form pyridine-3-formic acid and hydrogen chloride. Its hydrolysis speed is like that of rapid water, which is unstoppable. If it is placed in humid air, its deliquescence can be seen in a moment, which is the preliminary characterization of hydrolysis.
Pyridine-3-formyl chloride hydrochloride can undergo alcoholysis with alcohols to form corresponding ester compounds. This reaction is like a carefully choreographed "dance" in which acid chloride interacts with alcohols and goes through complex chemical steps to eventually form new ester products. Under appropriate catalyst and reaction conditions, this reaction can be carried out efficiently.
The compound can also undergo ammonysis with amines to form amide compounds. This process is like a "fusion" between two substances to form a stable amide structure. In the field of organic synthesis, complex molecules containing amide bonds are often constructed by this reaction.
The chemical properties of pyridine-3-formyl chloride hydrochloride are active, and it is like a "master key" in organic synthesis. It can open the door to the synthesis of many compounds and provide an important way for the preparation of various pyridine derivatives and related organic compounds. It plays an indispensable role in many fields such as medicinal chemistry and materials science.

Pyridine-3-formyl chloride hydrochloride is an important compound in organic chemistry. Its main uses are quite extensive, and I will describe them in detail.
Bearing the brunt, this compound has a significant effect in the field of drug synthesis. Gai can be used as a key intermediate due to its unique structure. Through a series of organic reactions, it can be ingeniously converted into various bioactive drug molecules. For example, some drugs used in the treatment of cardiovascular diseases, pyridine-3-formyl chloride hydrochloride can precisely introduce specific functional groups in its synthesis process, thereby building the core chemical structure, which has a profound impact on the activity and efficacy of the drug.
Furthermore, in the field of pesticide synthesis, it is also indispensable. The creation of pesticides requires precise design of molecular structures for the purpose of efficient insecticidal, bactericidal or weeding. Pyridine-3-formyl chloride can be used as an important starting material to react with other organic reagents to generate pesticide components with specific biological activities. Such pesticides can effectively resist crop diseases and pests, ensure the yield and quality of food, and contribute significantly to the development of agriculture.
In addition, in the field of materials science, pyridine-3-formyl chloride hydrochloride also shows unique value. For example, when preparing some high-performance polymer materials, it can participate in polymerization reactions as a functional monomer. The polymer formed by this reaction may have unique optical, electrical or mechanical properties, which can be applied to many high-end fields such as electronic devices and optical materials, and promote the continuous progress of materials science.
Again, in the basic research level of organic synthetic chemistry, pyridine-3-formyl chloride is often used as a classic reaction substrate. By studying its reaction characteristics and reaction mechanisms with different reagents, chemists can gain in-depth insight into the laws of organic reactions and develop novel organic synthesis methods. This not only enriches the theoretical knowledge of organic chemistry, but also provides innovative ideas and methods for the synthesis of novel compounds.
In conclusion, pyridine-3-formyl chloride plays a crucial role in many fields such as pharmaceuticals, pesticides, materials science, and basic research in organic synthesis, and plays a huge role in promoting the development of related fields.

The method of preparing pyridine-3-formyl chloride hydrochloride is a technique of chemical synthesis. Pyridine-3-carboxylic acid is first taken as the starting material, and thionyl chloride is often used as the chlorination reagent. The two are mixed in a suitable reaction vessel, and an appropriate amount of catalyst, such as N, N-dimethylformamide (DMF), is added to promote the reaction.
The reaction system is placed in a heating device at a moderate temperature, such as 60-80 ° C. The thionyl chloride reacts with pyridine-3-carboxylic acid, and the hydroxyl group of the acid is replaced by a chlorine atom to form pyridine-3-formyl chloride. Due to its activity, it is easy to combine with hydrogen chloride that may remain in the system to obtain pyridine-3-formyl chloride hydrochloride.
After the reaction is completed, the system is cooled, and then the excess thionyl chloride is distilled to remove, because its boiling point is relatively low. The remaining product is purified by recrystallization, and suitable solvents such as ether and petroleum ether are selected. After dissolving the product, it is slowly cooled to allow pyridine-3-formyl chloride to crystallize and precipitate. After filtration and drying, a pure product can be obtained. This process requires attention to the control of reaction conditions to ensure safety, and accurate operation of each step, in order to obtain high yield and purity of pyridine-3-formyl chloride hydrochloride.

Pyridine-3-formyl chloride hydrochloride is a chemical substance. When storing and transporting, you need to pay more attention to the following things:
First, it is related to storage. This substance needs to be stored in a cool, dry and well-ventilated place. Because of its hygroscopicity, if the environment is humid, it is easy to cause deliquescence and deterioration, so moisture protection is extremely critical. It should be placed in a sealed container to prevent contact with water vapor in the air. And it should be kept away from fire and heat sources. It is easy to cause decomposition or other chemical reactions due to heat, which may cause danger. In addition, it should be stored separately from oxidants and alkalis to avoid mixed storage to prevent violent chemical reactions.
Second, about transportation. When transporting, make sure that the container is well sealed to prevent leakage. The packaging needs to be solid and firm, able to withstand a certain external force impact, to avoid package damage during transportation. Transport vehicles should also have good ventilation conditions to reduce the risk of volatile gas accumulation. Transport personnel should be professionally trained and familiar with its characteristics and emergency treatment methods. During transportation, always pay attention to temperature changes to avoid high temperature environments. If a leak occurs, do not panic. Quickly isolate the leaked contaminated area and restrict personnel from entering and leaving. Emergency personnel need to wear protective equipment and collect and clean up leaks according to the correct method.

I think what you are asking is about the market price range of pyridine-3-formyl chloride hydrochloride. However, the price of this chemical often changes due to many factors, and it is difficult to give an exact price range.
First, the cost of raw materials. If the price of raw materials such as pyridine-3-formic acid and chlorination agent fluctuates, the price of pyridine-3-formyl chloride made from it will also change. If raw materials are scarce, prices will rise; if supplies are abundant, prices may fall.
Second, the preparation process also affects. The advanced and efficient process may reduce the production cost, resulting in a slightly lower price; if the process is complicated and the cost is high, the product price will not be low.
Third, the market supply and demand situation. If the demand is strong and the supply is limited, the price will rise; if the demand is low and the supply is excessive, the price will easily drop.
Fourth, the quality specification is related to the price. High purity, few impurities, the price is often higher than the ordinary quality.
Fifth, the sales area is also different. Different regions, due to the different transportation costs and local market environment, the price may be different.
Due to the intertwining of the above factors, the market price range of pyridine-3-formyl chloride hydrochloride is difficult to determine. To know the exact price, consult chemical product suppliers, distributors, or recent quotations on chemical product trading platforms to obtain a more accurate price range.