Pyridine 3 5 Dichloro 2 6 Difluoro
pyridine pyrrole pyrazine piperidine piperazine

pyridine, 3,5-dichloro-2,6-difluoro-

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    HS Code

    334666

    Chemical Formula C5HCl2F2N

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    Frequently Asked Questions

    As a leading pyridine, 3,5-dichloro-2,6-difluoro- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 3,5-dichloro-2,6-difluoropyridine?
    3% 2C5-difluoro-2% 2C6-difluorostyrene is an organic compound with special physical properties. It may be liquid at room temperature, colorless and transparent, and has a special odor. Due to the presence of fluorine atoms, its chemical properties are relatively stable, and its reactivity is different from that of ordinary olefins.
    From the perspective of physical properties, its density is less than that of water, it is difficult to dissolve in water, and it is soluble in some organic solvents, such as ethanol, ether, chloroform, etc. Due to the strong electronegativity of fluorine atoms, the polarity of molecules changes, which affects their solubility and density.
    The boiling point and melting point are also affected by the structure. The introduction of fluorine atoms increases the intermolecular force, causing the boiling point to rise. However, the specific value varies depending on the exact structure and impurities In addition, it has a certain volatility, and it needs to be sealed when storing to prevent volatilization loss.
    Furthermore, due to the carbon-carbon double bond of the molecule and the olefin properties, reactions such as addition and oxidation can occur, and the presence of fluorine atoms gives unique reactivity. In the field of organic synthesis or as a key intermediate, it is used to prepare fluorine-containing functional materials, drugs, etc., providing the possibility for the synthesis of fluorine-containing complex structural compounds.
    What are the chemical properties of 3,5-dichloro-2,6-difluoropyridine?
    3,5-Difluoro-2,6-dichloropyridine is an organic compound with the following chemical properties:
    First, it has high nucleophilic substitution reactivity. Because of the fluorine and chlorine atoms in the molecule, these halogen atoms can be replaced by nucleophilic reagents under suitable conditions. In the case of reagents containing nucleophilic groups such as hydroxyl and amino groups, halogen atoms can react with them to form new compounds. Taking alcohol nucleophilic reagents as an example, under the catalytic action of bases, halogen atoms will be replaced by alkoxy groups to produce corresponding ether compounds. This property makes it a key intermediate in the field of organic synthesis for the construction of diverse functional compounds.
    Second, reduction reactions can occur. Halogen atoms in molecules can be reduced and removed under the action of specific reducing agents. For example, the reduction system composed of metal zinc and acid can realize the gradual reduction of halogen atoms, and then change the molecular structure and properties, providing an effective way for the synthesis of specific structural organic compounds.
    Third, it has a certain degree of acidity. The electron cloud density on the pyridine ring is reduced by the electron-absorbing effect of halogen atoms, making it easier to give lone pair electrons on the nitrogen atom of the pyridine ring, so that it shows acidity to a certain extent and can react with strong bases to generate corresponding salt compounds.
    Fourth, it can participate in the coupling reaction catalyzed by metals. Under the catalysis of transition metal catalysts such as palladium and nickel, the halogen atom of 3,5-difluoro-2,6-dichloropyridine can be coupled with organic compounds containing unsaturated bonds, such as alkenes, alkynes, etc. to realize the construction of carbon-carbon bonds. This is widely used in complex organic molecules and drug synthesis, and can be used to build molecular frameworks with specific structures and functions.
    What are the main uses of 3,5-dichloro-2,6-difluoropyridine?
    3% 2C5-dioxo-2% 2C6-dienoheptanoic acid, its main use is in the field of organic synthesis. This compound has a unique structure and plays a key role in many organic reactions.
    In the great cause of organic synthesis, many delicate reactions rely on these compounds as starting materials or key intermediates. It can participate in cyclization reactions to build complex cyclic structures, which is an important strategy for building a specific skeleton in organic synthetic chemistry. With its special unsaturated bonds and oxygen-containing functional groups, it can selectively react with various nucleophiles and electrophiles, and then derive a variety of products. < Br >
    And because of the characteristics of dioxy and diene in its structure, it can be used to synthesize bioactive natural product analogs. In the field of medicinal chemistry, by simulating the structure of natural products, it is expected to develop new types of drug molecules. It can also be used as a monomer or cross-linking agent for polymerization reactions to prepare polymer materials with special properties, and also has potential application value in the field of materials science. It has shown important uses in many scientific frontiers such as organic synthesis, drug research and development, and material preparation. It is like a delicate key that opens many unknown scientific doors and promotes the continuous development of related fields.
    What are the preparation methods of 3,5-dichloro-2,6-difluoropyridine?
    3% 2C5-difluoro-2% 2C6-dicyanopyridine is an important intermediate in the field of organic synthesis, and is widely used in many fields such as medicine and pesticides. Its preparation methods are rich and diverse, as detailed below:
    ** First: Reaction with pyridine derivatives as starting materials **
    Take specific pyridine derivatives, in an appropriate reaction vessel, first add a suitable organic solvent, such as dichloromethane, N, N-dimethylformamide, and stir well. Then add halogenating reagents in a certain order, such as fluorinated halogenating agents, and the reaction needs to be carried out under precise control of temperature and pressure. During the reaction, closely monitor the reaction process, and use thin layer chromatography (TLC) and other means. When the reaction reaches the expected level, the target product can be obtained by separation and purification through extraction, washing, drying, column chromatography and other steps. In this process, temperature control is very critical, and a slight deviation may cause side reactions to occur, affecting the purity and yield of the product.
    ** Second: Build a pyridine ring through a multi-step reaction and introduce a substituent **
    First, based on simple organic compounds, the structure of the pyridine ring is constructed by condensation, cyclization and other reactions. For example, select a suitable aldehyde, ketone, and amine compound, and carry out a condensation reaction under the catalysis of an acid or base to form the prototype of the pyridine ring. After that, halogenation and cyanidation of the specific position of the pyridine ring are carried out, and fluorine atoms and cyano groups are introduced. After each step of the reaction is completed, it is necessary to carefully separate and purify the intermediates to ensure the smooth subsequent reaction. Although this method is complicated in steps, the reaction conditions are properly controlled, and high purity products can be obtained.
    ** Third: The coupling reaction with the help of transition metal catalysis **
    uses halogen-containing pyridine derivatives and fluorine-containing and cyanyl reagents as raw materials, and the coupling reaction occurs under the action of transition metal catalysts. For example, transition metal catalysts such as palladium and nickel are selected, with suitable ligands, and react in a suitable base and solvent environment. This method has high selectivity and can accurately introduce fluorine and cyanyl groups at designated positions in the pyridine ring. However, transition metal catalysts are expensive, and post-treatment needs to be careful to avoid metal residues affecting the quality of the product.
    When preparing 3% 2C5-difluoro-2% 2C6-dicyanopyridine, the preparation method should be reasonably selected according to actual demand, raw material availability, cost considerations and product purity requirements, and the reaction conditions and post-treatment steps should be strictly controlled to obtain high-quality products efficiently.
    What are the precautions for storing and transporting 3,5-dichloro-2,6-difluoropyridine?
    3,5-Difluoro-2,6-dichloropyridine is a highly toxic chemical. When storing and transporting, you must be careful and keep in mind many key precautions:
    First, the storage place must be strictly selected. It must be placed in a cool and well-ventilated place, away from fire and heat sources. Because of its flammability, it is very easy to cause combustion and explosion in case of open flames and hot topics. The warehouse temperature should not exceed 30 ° C, and the relative humidity should be controlled below 80%. And it should be stored separately from oxidants, acids, bases, etc., and must not be mixed to prevent violent chemical reactions.
    Second, the packaging must be solid and reliable. Appropriate packaging materials should be used to ensure a good seal and prevent leakage. It is common to wrap a buffer material in a glass bottle and place it in a sturdy wooden box or iron drum. Warning labels should be clearly marked on the packaging, such as "highly toxic" and "flammable" to remind everyone to pay attention.
    Third, the transportation process is particularly critical. The transportation vehicle must be equipped with the corresponding variety and quantity of fire protection equipment and leakage emergency treatment equipment. Summer transportation should be selected in the morning and evening to avoid high temperature and hot sun. During transportation, ensure that the container does not leak, collapse, fall or damage. The tank (tank) car used during transportation should have a grounding chain, and holes can be set in the tank to baffle to reduce static electricity generated by shock. It is strictly forbidden to mix and transport with oxidants, acids, alkalis, etc. Road transportation should be carried according to the specified route, and do not stop in residential areas and densely populated areas.
    Fourth, personnel protection is essential. Storage and transportation personnel must be professionally trained and strictly abide by the operating procedures. Protective equipment such as gas masks, chemical safety protective glasses, rubber acid and alkali-resistant gloves should be worn during operation to prevent contact poisoning. If accidentally exposed, they should be treated immediately according to corresponding first aid measures and sent to the hospital in time.