Pyridine 2 Fluoro 3 Methoxy
pyridine pyrrole pyrazine piperidine piperazine

Pyridine, 2-fluoro-3-methoxy-

    Specifications

    HS Code

    701882

    Chemical Formula C6H6FNO
    Molecular Weight 127.12
    Appearance Typically a colorless to light - yellow liquid
    Boiling Point Data may vary, around a certain range depending on purity
    Melting Point Data may vary
    Density Specific value depending on conditions
    Solubility Soluble in some organic solvents
    Flash Point Relevant value based on testing
    Vapor Pressure Value dependent on temperature
    Pka Characteristic value related to its acidic - basic properties

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    General Information
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    Frequently Asked Questions

    As a leading Pyridine, 2-fluoro-3-methoxy- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of 2-fluoro-3-methoxypyridine?
    The chemical properties of 2-% tit-3-methoxyphenyl group have specific reaction characteristics and physical properties. In this compound, the presence of methoxy group has a great influence on its chemical behavior. Methoxy group is the power supply group, which can increase the electron cloud density of the benzene ring, making it more prone to electrophilic substitution.
    As for electrophilic substitution reactions, due to the increase in the electron cloud density of the adjacent and para-position of the methoxy group, the electrophilic reagents tend to attack these two positions. For example, in halogenation reactions, halogen atoms easily replace hydrogen atoms in the ortho or para-position of the methoxy group on the benzene ring to form corresponding halogenated products. This is because the intermediate carbon positive ion formed during the reaction can obtain stronger electron delocalization and stability of the methoxy group in the adjacent and para-position.
    And during the oxidation reaction, although the methoxy group is relatively stable, the tibial group of the side chain of the benzene ring can be oxidized under suitable conditions. In case of strong oxidizing agent, the tibial group can be gradually oxidized to an aldehyde group or even a carboxyl group.
    Furthermore, the solubility of the compound also has characteristics. Due to the presence of methoxy group, it has good solubility in organic solvents such as ethanol and ether, but relatively poor solubility in water. This is because the methoxy group is a hydrophobic group, which reduces the hydrophilicity of the whole molecule.
    In addition, the spatial structure of 2% tibia-3-methoxyphenyl also affects its chemical properties. The spatial orientation of methoxy and tibia will affect the interaction between molecules, and then affect their physical properties such as melting point and boiling point. And the steric resistance of the molecule will also affect the reactivity. If the electrophilic reagent is large, it may be difficult to attack the methoxy ortho-site due to the steric resistance, resulting in a change in the reaction selectivity.
    What are the physical properties of 2-fluoro-3-methoxypyridine?
    2-% alkene-3-methoxybenzaldehyde, which is an organic compound. It has the following physical properties:
    Viewed at room temperature, it is a colorless to light yellow liquid. Under specific lighting and environmental conditions, or due to the conjugated system of unsaturated bonds and benzene rings in the molecular structure, it shows a slight color change and has a certain visual recognition.
    Smell it, emits a unique aromatic odor. Due to the structural characteristics of benzene ring and aldehyde group, the odor is both fragrant and soft, and may have potential applications in fragrance and other fields.
    Its boiling point, due to intermolecular forces, includes van der Waals forces and weak hydrogen bonds, and is about a certain temperature range. This property is conducive to separation and purification by distillation and other means.
    In terms of melting point, due to molecular regularity and interaction, it is in a specific low temperature range. In the solid state, the orderly arrangement of molecules is affected by the structure.
    In terms of solubility, it is slightly soluble in water, because its molecular polar part is aldehyde and methoxy, while the non-polar alkenyl group and benzene ring account for a large proportion, and the force between water molecules is weak; but it is soluble in common organic solvents, such as ethanol, ether, etc. Due to the similar principle of miscibility, it can form an appropriate force with organic solvent molecules.
    The density is slightly smaller than that of water, and it will float on the water surface in the stratification experiment. This is caused by the molecular mass and the intermolecular accumulation mode. In addition, due to the presence of carbon-carbon double bonds, aldehyde groups, and methoxy groups in the structure, it may undergo chemical reactions under the influence of external factors such as light and heat, resulting in changes in physical properties, such as color deepening and odor changes.
    What are the main uses of 2-fluoro-3-methoxypyridine?
    2-%E6%B0%9F-3-%E7%94%B2%E6%B0%A7%E5%9F%BA%E5%90%A1%E5%95%B6, it can be used as a chemical compound. This material has important uses in engineering, engineering, and other fields.
    In engineering, 2-%E6%B0%9F-3-%E7%94%B2%E6%B0%A7%E5%9F%BA%E5%90%A1%E5%95%B6 often used as a raw material for synthesis. Because of its molecular properties, it can be used to create more complex compounds. For example, in the synthesis of some polymer materials, it can be filled with a series of steps to form a polymer with specific properties. It is widely used in plastics, rubber and other materials.
    In the field, 2-%E6%B0%9F-3-%E7%94%B2%E6%B0%A7%E5%9F%BA%E5%90%A1%E5%95%B6 also plays an important role. It may have a certain biological activity and can be used as a starting material for chemical research. Through chemical engineering, scientists can develop compounds with specific chemical effects for the treatment of various diseases. For example, the research of certain antibacterial and anti-inflammatory substances, 2-%E6%B0%9F-3-%E7%94%B2%E6%B0%A7%E5%9F%BA%E5%90%A1%E5%95%B6 may play an important role in the synthesis of their molecules, providing strong support for the development of their technologies.
    As a result, 2-%E6%B0%9F-3-%E7%94%B2%E6%B0%A7%E5%9F%BA%E5%90%A1%E5%95%B6, with its special characteristics, has an indispensable position in the synthesis of engineering and research, and promotes the development of related technologies.
    What are the synthesis methods of 2-fluoro-3-methoxypyridine?
    To prepare 2-alkynyl-3-methoxyphenyl, there are many methods. First, it can be obtained by coupling the corresponding halogenated aromatic hydrocarbon with the alkynyl fund reagent. For example, take halogenated aromatics and make them react with alkynyl lithium or alkynyl magnesium reagents in a suitable solvent at low temperature or room temperature. This process requires strict control of the reaction conditions, and an anhydrous and oxygen-free environment is essential, otherwise side reactions will easily occur, affecting the purity and yield of the product.
    Second, it can be prepared by nucleophilic substitution reaction. The nucleophilic reagent containing alkynyl group interacts with the halogenated benzene derivative containing methoxy group. Both the activity of nucleophilic reagents and the activity of halogenated benzene derivatives have a great impact on the reaction. The choice of moderate activity can not only ensure the smooth progress of the reaction, but also avoid overreaction. At the same time, the choice of reaction solvent and base cannot be ignored. The appropriate solvent can promote the dissolution and reaction of the reactants, and the appropriate base can help the formation of nucleophilic reagents or promote the equilibrium movement of the reaction.
    Furthermore, the cross-coupling reaction catalyzed by transition metals can be used. Transition metals such as palladium and copper are used as catalysts to couple alkynyl-containing compounds and methoxybenzene derivatives under mild conditions with the assistance of ligands. The activity and selectivity of transition metal catalysts need to be finely regulated, and the ligand structure will also significantly affect the performance and reaction selectivity of the catalysts. By adjusting the catalyst and ligand, precise control of the reaction check point and product configuration can be achieved.
    can start from the raw material and construct the target structure through multi-step reaction. The benzene ring is methoxylated first, and then the alkynyl group is introduced. Although this multi-step route is complicated, each step can be optimized separately, which is beneficial to improve the purity and yield of the product. The reaction conditions and intermediate purification of each step need to be carefully designed and operated to ensure the feasibility and efficiency of the entire synthesis route.
    What are the precautions for storing and transporting 2-fluoro-3-methoxypyridine?
    2-%E6%B0%9F-3-%E7%94%B2%E6%B0%A7%E5%9F%BA%E5%90%A1%E8%80%85, this is a delicate chemical product, and many matters must be paid attention to during storage and transportation.
    When storing, the temperature and humidity of the environment are the first priority. This material likes a cool and dry place. If it is placed in a warm and humid place, it may cause deterioration. Because of excessive temperature and humidity, or cause changes in the internal structure, resulting in damage to the efficacy. Therefore, the temperature of the warehouse should be controlled below [X] degrees Celsius, and the humidity should be maintained within [X]% to be safe.
    Furthermore, it is quite sensitive to light. Under direct light, or trigger a chemical reaction, its quality will be degraded. The storage place should be equipped with shading facilities to protect it from light intrusion.
    As for the transportation link, shock resistance is the key. The texture of this material may be fragile, and it may be damaged due to bumps and vibrations during transportation. Therefore, it needs to be properly wrapped with soft and cushioning materials to ensure stability in transit.
    At the same time, the means of transportation also need to be carefully selected. Do not transport with corrosive and oxidizing materials to prevent interaction and accidental changes. In addition, the speed of transportation should not be too fast, and smooth driving can reduce the risk.
    And transport personnel must be familiar with the characteristics of this object and emergency treatment methods. In case of emergencies such as leaks, they can be dealt with quickly and properly to avoid the expansion of harm. In this way, during storage and transportation, all things should be paid attention to to ensure the quality and safety of 2-%E6%B0%9F-3-%E7%94%B2%E6%B0%A7%E5%9F%BA%E5%90%A1.