Pyridine, 2-chloro-5-methoxy- (9CI)

9CI refers to 2-cyano-5-methoxy pyridine, which is an organic compound. Its chemical properties are rich and diverse, and it has important uses in many fields.
From a structural point of view, cyano and methoxy groups are introduced into the pyridine ring of the compound, and these two substituents significantly affect its chemical activity. Cyano is a strong electron-absorbing group, which can reduce the electron cloud density of the pyridine ring, thereby enhancing the activity of electrophilic substitution on the ring. For example, in halogenation reactions, it is easier to react with halogenated reagents to form halogenated derivatives. Methoxy is an electron-donating group, which can affect the electron cloud density at a specific position of the pyridine ring, making the electrophilic substitution reaction position-selective.
In terms of acidity and alkalinity, 2-cyano-5-methoxypyridine can react with acids to form corresponding salts due to the alkalinity of the nitrogen atom of pyridine. This property is of great significance in the field of medicinal chemistry. It can improve the solubility and stability of compounds by forming salts, which is convenient for the development of pharmaceutical preparations.
This compound can also participate in a variety of organic synthesis reactions. For example, cyanyl groups can undergo hydrolysis to form carboxyl groups, or nucleophilic addition reactions with nucleophiles, whereby other functional groups can be introduced to synthesize compounds with more complex structures. The oxygen atom of the methoxy group can also be used as a nucleophilic check point to participate in nucleophilic substitution reactions and realize molecular modification and construction.
At the level of biological activity, compounds containing pyridine structures often have certain biological activities. 2-Cyanogen-5-methoxypyridine may exhibit potential activities in antibacterial, antiviral or antitumor, providing the possibility for the development of new drugs. In the field of materials science, its unique structure may endow materials with specific electrical and optical properties, which can be used to prepare organic optoelectronic materials.

The common uses of 2-cyanogen-5-methoxypyridine referred to by 9CI are as follows:
In the field of medicinal chemistry, it can be used as an important intermediate. Due to its special chemical structure, it can participate in a variety of chemical reactions, and then construct complex compounds with biological activity. For example, when developing drugs targeting specific disease targets, 2-cyanogen-5-methoxypyridine can be used as a key starting material. Through a series of chemical modifications, such as condensation reactions with other compounds containing nitrogen, oxygen and other functional groups, a pharmacologically active parent nucleus structure can be constructed, laying the foundation for the development of new drugs.
In the field of pesticides, it also plays an important role. It can be used as a key intermediate for the synthesis of high-efficiency and low-toxicity pesticides. By reacting with different organic reagents, compounds with insecticidal, bactericidal or herbicidal activities are generated. For example, by combining with some sulfur-containing and phosphorus-containing reagents, pesticide products with targeted effects on specific pests or weeds can be developed, which helps to improve crop yield and ensure agricultural production.
In terms of materials science, 2-cyanogen-5-methoxypyridine also shows certain application potential. The polymerization reaction in which it participates can prepare polymer materials with special properties. For example, when synthesizing functional polymers, introducing them into the polymer backbone or side chain gives the polymer unique electrical, optical or thermal properties, which can be used to make advanced materials such as organic Light Emitting Diodes (OLEDs) and sensors.
In conclusion, 2-cyano-5-methoxypyridine has a wide range of important uses in many fields such as medicine, pesticides and materials science due to its unique chemical structure, providing a key chemical basis for technological innovation and product development in various fields.

To prepare 2-cyano-5-methoxypyridine (9CI), the common synthesis methods are as follows:
First, a suitable pyridine derivative is used as the starting material. The methoxy group is introduced at a specific position of the pyridine ring before the pyridine ring. A compound containing a pyridine ring and prone to substitution reactions at the corresponding position can be found. A halogenated alkane (such as halomethane, whose halogen atoms can be bromine, chlorine, etc.) can be used to introduce the methoxy group into the pyridine ring through nucleophilic substitution reaction under the action of a base. This base can be selected from inorganic bases such as potassium carbonate and sodium carbonate, and reacted in suitable organic solvents (such as N, N-dimethylformamide, acetonitrile, etc.
After the methoxy group is successfully introduced, the cyanyl group is introduced again. Halogenated pyridine derivatives (the halogen atom can be bromine, chlorine) can be used to react with cyanide reagents (such as cuprous cyanide, potassium cyanide, etc.). If cuprous cyanide is used, in a suitable ligand and organic solvent, a nucleophilic substitution reaction occurs under heating conditions, so that the cyanyl group replaces the halogen atom, resulting in the target product 2-cyano- 5-methoxy pyridine.
Second, the construction of pyridine rings can also be started. Pyridine ring structures are constructed through multi-step reactions with nitrogen-containing, carbonyl-containing and methoxy-containing related raw materials. For example, using β-ketone esters, ammonia and formaldehyde containing methoxy groups as the starting materials, the pyridine ring is formed through a series of reactions such as condensation and cyclization. First, the β-ketone ester and ammonia undergo condensation reaction to form a nitrogen-containing intermediate, and then the intermediate is further cyclized with the aldehyde containing methoxy groups under suitable conditions to form a pyridine ring structure. This process requires controlling the reaction conditions, including temperature, pH and reaction time, to ensure that the pyridine ring can be constructed in the desired way. After the pyridine ring is constructed, the groups on the ring are modified and adjusted according to the specific situation, and finally the target product 2-cyano-5-methoxy pyridine is obtained. In the process of
synthesis, attention should be paid to the precise regulation of the proportion of reactants and reaction conditions in each step to improve the yield of the reaction and the purity of the target product.

9CI refers to 2-chloro-5-methoxypyridine, which is worth exploring in today's market prospects.
In the field of Guanfu medicine, this compound may have extraordinary potential. Because of its unique structure, it may be a key intermediate in drug development. The creation of many new drugs often relies on such characteristic structures to build the core of efficacy. Today, the pharmaceutical industry is hungry for innovative drugs, and R & D institutions are competing to find novel and effective ingredients. If 2-chloro-5-methoxypyridine can make a contribution here and participate in the synthesis of specific new drugs, whether it is the treatment of difficult diseases or the optimization of drug use for common diseases, it can win a place in the market, and the future may be bright.
As for the field of pesticides, it may also have something to do. At present, green, efficient and low-toxicity pesticides are the mainstream of development. If 2-chloro-5-methoxypyridine can be reasonably designed and incorporated into new pesticide molecules to give pesticides better biological activity, selectivity and environmental friendliness, it will definitely meet market demand. Nowadays, farmers and agricultural enterprises have a strong willingness to purchase high-quality pesticides. If pesticides based on this compound can effectively control pests and diseases, and are friendly to the ecological environment, they can occupy a share in the vast pesticide market.
However, it is also necessary to clearly observe that although the market prospect is promising, there are also challenges. The optimization of the synthesis process is extremely important. If the cost remains high, the production efficiency is not good, and even if it has good performance, it is difficult to widely promote. And the market competition is fierce. There are many similar or alternative products. To stand out, we need to make efforts in quality, price, promotion and other aspects. Only by seizing the opportunity and overcoming the problem can 2-chloro-5-methoxypyridine have a broad market future.

F 9CI, that is, 2-cyano-5-methoxypyridine. When storing and transporting this product, many matters need to be paid attention to.
Safety first. Because of its toxicity and danger, it must be placed in a special warehouse when storing, and the warehouse should be cool, well ventilated, away from fire and heat sources. It is strictly forbidden to mix and transport with oxidants, acids, alkalis, etc., to prevent violent chemical reactions and cause danger.
Furthermore, the packaging must be tight. Suitable packaging materials should be used to ensure that it does not leak during transportation and storage. Warning labels should be clearly marked on the outside of the package, such as "toxic" and "careful handling", so that the relevant personnel can know the danger at a glance and handle it with caution.
During transportation, the means of transportation should also meet safety requirements. Drivers and escorts must be familiar with the characteristics of this object and emergency disposal methods. During driving, bumps and vibrations should be avoided to prevent damage to the package. In case of emergencies such as leaks, they should be able to quickly respond to it according to the established emergency plan to reduce harm.
In addition, the temperature and humidity of the storage environment cannot be ignored. The temperature and humidity range needs to be precisely regulated according to its physical and chemical properties. Excessive temperature, or cause its volatilization to increase; excessive humidity, or cause its deliquescence and other conditions, all damage its quality and safety.
In short, 2-cyanogen-5-methoxypyridine must be strictly controlled in all aspects from safety, packaging, transportation tools to environmental conditions during storage and transportation, and must not be slack to ensure foolproof.