Pyridine 2 6 Dichloro 4 Iodo
pyridine pyrrole pyrazine piperidine piperazine

Pyridine, 2,6-dichloro-4-iodo-

    Specifications

    HS Code

    235234

    Chemical Formula C5H2Cl2IN
    Molecular Weight 299.89
    Appearance Solid (predicted)
    Boiling Point Unknown
    Melting Point Unknown
    Density Unknown
    Solubility In Water Low (predicted)
    Vapor Pressure Unknown
    Flash Point Unknown
    Stability Stable under normal conditions (predicted)
    Toxicity Potentially toxic (iodine and chlorine containing, prediction)
    Pka Unknown
    Logp High (predicted due to non - polar groups)

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    General Information
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    Frequently Asked Questions

    As a leading Pyridine, 2,6-dichloro-4-iodo- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of 2,6-dichloro-4-iodopyridine?
    2% 2C6-dichloro-4-nitroaniline is an organic compound. Its properties are as follows:
    This substance is a yellow crystalline powder, which is insoluble in water, but soluble in some organic solvents, such as ethanol and acetone. Under normal temperature and pressure, the properties are still stable.
    From the perspective of chemical activity, due to the presence of chlorine atoms and nitro groups, the chemical properties are relatively active. Nitro is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and make the benzene ring more prone to nucleophilic substitution. Although chlorine atoms are also electron-absorbing groups, they can be replaced by other nucleophilic reagents under specific conditions, such as high temperature and strong alkali environment.
    In the field of organic synthesis, 2% 2C6-dichloro-4-nitroaniline has a wide range of uses and is often used as an intermediate. Nitro groups can be converted into amino groups by reduction reaction to obtain 2% 2C6-dichloro-4-aminoaniline, which is an important raw material for the synthesis of various dyes, pigments and medicines. At the same time, because its structure contains chlorine and nitro groups, it gives the product a specific color and stability, which is of great significance to the dye industry.
    However, 2% 2C6-dichloro-4-nitroaniline has certain toxicity and irritation. Human contact or inhalation may damage health and irritate the eyes, skin and respiratory tract. Therefore, when using and storing, it is necessary to follow safe operating procedures and take protective measures to avoid harm to the human body and the environment.
    What are the physical properties of 2,6-dichloro-4-iodopyridine?
    2% 2C6-dioxy-4-pyrimidinone, this physical property has various characteristics. At room temperature, it is in the shape of a solid state, and it may be in the shape of a white powder or a crystalline state. The quality is uniform and delicate, like finely crushed snowflakes or clear ice crystals.
    As far as the melting point is concerned, it has a specific value. This value is an important physical sign that allows it to melt from a solid state to a liquid state at a specific temperature, completing the transformation of the state of matter. The characteristic of this melting point is of great significance in many processes and applications. For example, in some synthetic processes, the control of temperature is closely related to the melting point, which is related to the purity and quality of the product.
    In terms of solubility, in specific solvents, it shows different solubility properties. In some organic solvents, it can be moderately dissolved, seems to be integrated into it, and fuses with it; in water, its solubility may be limited, and it can only be dissolved a little, just like a stone thrown into a shoal, making it difficult to make waves. This solubility characteristic is a key consideration in operations such as separation, purification, and preparation of solutions, which determines the choice of solvent to achieve the best effect.
    In terms of stability, in normal environments, without the action of special chemical reagents or extreme conditions, its structure is stable, and it can maintain its own chemical composition and characteristics for a long time, just like a calm person who sticks to himself in the hustle and bustle of the world. However, when exposed to strong acids, alkalis, and other strengthening effects, or extreme physical environments such as high temperature and high pressure, its stability may be damaged, causing chemical reactions, resulting in structural changes, and the formation of different products.
    What are the main uses of 2,6-dichloro-4-iodopyridine?
    2% 2C6-dioxy-4-pyrimidinone, its main uses are as follows:
    This compound is of great significance in the field of medicine. It is often used as a key intermediate in the synthesis of anti-metabolic anti-tumor drugs. Taking fluorouracil as an example, 2% 2C6-dioxy-4-pyrimidinone can introduce specific groups through a series of reactions, optimize the drug structure, enhance the targeting and inhibitory effect on tumor cells, and interfere with the nucleic acid synthesis process of tumor cells, thereby inhibiting the proliferation of tumor cells.
    It also plays an important role in the field of pesticides. The preparation of some pyrimidine herbicides requires this as a raw material. By modifying its structure, herbicides with high herbicidal activity, low toxicity and environmental friendliness can be developed. These herbicides can precisely act on specific physiological processes of weeds, such as inhibiting photosynthesis or amino acid synthesis of weeds, achieving efficient herbicide while reducing adverse effects on crops and the environment.
    In addition, in organic synthesis chemistry, 2% 2C6-dioxy-4-pyrimidinone can participate in the construction of a variety of complex organic compounds due to its unique structure. Due to the active checking points such as carbonyl and nitrogen atoms in the molecule, reactions such as nucleophilic substitution and cyclization can occur, providing an effective way for the synthesis of organic molecules with special structures and functions, and assisting the development of new functional materials or biologically active substances.
    What are the synthesis methods of 2,6-dichloro-4-iodopyridine?
    The synthesis methods of 2% 2C6-dihydro-4-pyrimidinone compounds are diverse, and the following are described in detail:
    ** I. Biginelli reaction **
    This is a classic synthesis method. Ethyl acetoacetate, urea and benzaldehyde are used as raw materials, and under the catalysis of concentrated hydrochloric acid, heated and refluxed in ethanol to obtain the target product. The reaction mechanism is exquisite. First, benzaldehyde and ethyl acetoacetate condensate to form an enol intermediate, and then cyclize with urea. After multiple steps of conversion, 2% 2C6-dihydro-4-pyrimidinone is obtained. The raw materials of this method are common and easy to obtain, and the operation is not complicated. However, the reaction conditions are relatively harsh, the concentrated hydrochloric acid is highly corrosive, the equipment requirements are high, and there are many side reactions, and the yield is limited.
    ** Second, the microwave radiation method **
    is improved on the basis of the traditional Biginelli reaction. Benzoic acid, urea and ethyl acetoacetate are used as raw materials. Under microwave radiation, anhydrous ethanol is used as a solvent, and p-toluenesulfonic acid is used as a catalyst. Microwave radiation can make the molecules vibrate and rotate rapidly, and the energy is efficiently transferred, and the reaction rate is greatly improved. Compared with traditional heating, its reaction time is short, the yield is quite high, the side reactions are few, the energy consumption is reduced, and the advantages of green environmental protection are obvious. < Br >
    ** III. Solid-phase synthesis method **
    The reactants are loaded on the solid-phase support for reaction. For example, urea is attached to a polystyrene resin, and then reacted with ethyl acetoacetate and aldehyde under suitable conditions. The method is simple to separate and purify, the product is easy to cut from the solid-phase support, can avoid cumbersome column chromatographic separation, is suitable for high-throughput synthesis, and can quickly build a compound library, providing many candidate compounds for new drug development.
    ** IV. Ionic liquid catalysis method **
    Ionic liquid is used as the catalyst and reaction medium. For example, the reaction of ethyl acetoacetate, urea and aldehyde is catalyzed by [bmim] BF ionic liquid. Ionic liquids have the advantages of low volatility, high stability, and designability, which can improve the reaction environment, enhance the solubility of reactants and catalyst activity. The reaction conditions are mild, the yield is good, and ionic liquids can be recycled and repurposed, which is in line with the concept of green chemistry.
    What are the precautions for storing and transporting 2,6-dichloro-4-iodopyridine?
    2% 2C6-difluoro-4-chloropyridine This substance requires attention to many matters during storage and transportation.
    One is related to storage. Because of its nature, it may be more active, and it needs to be stored in a dry, cool and well-ventilated place. It must not be kept in a humid place. It is easy to cause chemical reactions and deterioration in a humid environment. And the temperature must also be strictly controlled. If it is too high or causes decomposition, it is too low or affects its physical state. Therefore, the storage temperature should be maintained in a suitable range. In addition, it should be stored separately from oxidants, acids, bases, etc. to prevent mutual reactions. Because it may be toxic and corrosive to a certain extent, the storage place must be locked and kept, and a special person should be responsible to prevent unrelated personnel from accidentally touching and misusing it.
    Second, as for transportation. Before transportation, make sure that the packaging is complete and well sealed. Packaging materials must be able to effectively resist vibration, collision and friction to prevent the leakage of items caused by package damage. During transportation, follow the relevant regulations on the transportation of hazardous chemicals, and select qualified transportation enterprises and transportation vehicles. Transportation vehicles should be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. Driving routes should also be carefully planned to avoid densely populated areas and environmentally sensitive areas. Transportation personnel must be professionally trained and familiar with the characteristics of the items being transported and emergency treatment methods. In the event of an accident such as a leak, it should be properly handled immediately according to the established emergency plan to prevent the harm from expanding. Therefore, it is necessary to ensure the safety of 2% 2C6-difluoro-4-chloropyridine during storage and transportation.