Pyridine-2,5-dicarboxylic acid dimethyl ester

Dimethyl pyridine-2,5-dicarboxylate is one of the organic compounds. It has unique chemical properties.
This compound is solid, mostly white to light yellow crystalline powder. In terms of solubility, it is quite soluble in common organic solvents such as ethanol and acetone, but its solubility in water is relatively low.
In the chemical structure of dimethyl pyridine-2,5-dicarboxylate, the pyridine ring is connected to the dimethyl dicarboxylate group, giving it certain stability and reactivity. Pyridine ring contains nitrogen atoms, which are weakly basic and can react with acids to form corresponding salts. < Br >
Its ester group part can undergo hydrolysis reaction under basic or acidic conditions. In alkaline environments, hydrolysis is relatively rapid, and ester groups are broken to form corresponding carboxylic salts and alcohols; under acidic conditions, the hydrolysis reaction is relatively slow, and finally pyridine-2,5-dicarboxylic acid and methanol are formed.
Furthermore, the pyridine ring of dimethyl pyridine-2,5-dicarboxylate can undergo electrophilic substitution reaction. Due to the electronic effect of nitrogen atoms, the electron cloud density at a specific position on the pyridine ring changes, which in turn affects the attack check point of electrophilic reagents. In general, the 3-position and 4-position of the pyridine ring are prone to electrophilic substitution, which makes it a key intermediate in the field of organic synthesis for the construction of more complex organic molecular structures.
In addition, the compound is at risk of combustion when heated or exposed to open flames. When burning, it may produce irritating fumes, which contain products such as nitrogen oxides and carbon dioxide. Therefore, when storing and using dimethyl pyridine-2,5-dicarboxylate, it is necessary to pay attention to fire protection and take appropriate ventilation measures to ensure the safety of the operating environment.

The common synthesis methods of dimethyl pyridine-2,5-dicarboxylate are roughly as follows.
One is to use pyridine-2,5-dicarboxylic acid as the starting material, so that it is esterified with methanol under the catalysis of strong acids such as concentrated sulfuric acid. In this process, the acid interacts with the alcohol, and through the nucleophilic substitution mechanism, the carboxyl group of the carboxylic acid dehydrates and condenses with the hydroxyl group of the methanol to form an ester bond. The reaction needs to be properly heated and the reaction time and temperature are controlled. Usually, the reaction is refluxed under heating conditions for several hours. After the reaction is completed, the target product pyridine-2,5-dicarboxylate can be obtained through post-treatment steps such as alkali neutralization, extraction, and distillation.
The second can be started from 2,5-dimethylpyridine, and the methyl group is first converted into a carboxyl group through oxidation reaction. Commonly used oxidants such as potassium permanganate, potassium dichromate, etc., oxidize 2,5-dimethylpyridine to pyridine-2,5-dicarboxylic acid. Then follow the above esterification step to react with methanol under acid catalysis to form pyridine-2,5-dicarboxylic acid dimethyl ester. This route needs to be controlled by the conditions of the oxidation reaction to prevent side reactions such as excessive oxidation.
Or start with suitable halogenated pyridine derivatives and introduce carboxyl groups through metal-catalyzed carboxylation reaction, and then perform esterification. For example, using halogenated pyridine as a substrate, in the presence of metal catalysts and ligands such as palladium and nickel, it reacts with carbon monoxide, alcohol and other reagents. After multi-step conversion, pyridine-2,5-dicarboxylic acid derivatives are first formed, and then esterified to obtain the target product. This method requires high reaction conditions and catalysts, and precise regulation of reaction parameters is required to ensure the smooth progress of the reaction.

Dimethyl pyridine-2,5-dicarboxylate, which is widely used in the field of medicine, can be used as a key intermediate to help synthesize a variety of drugs, such as anti-tumor drugs. Through its unique structure, it participates in the construction of drug molecules, affecting drug activity and efficacy, and contributing to the solution of cancer problems. In the field of materials science, it can assist in the synthesis of special polymer materials, such as materials with unique optical and electrical properties, or can be used to make new electronic devices, in electronic screens, sensors, etc.; in the field of organic synthesis, it is an important raw material and reagent. It can build complex organic molecules through various reactions, such as esterification, substitution, etc., expand the variety of organic compounds, and enrich the chemical treasure house of organic synthesis. It is used in the fine chemical industry, or in the preparation of high-end fragrances, additives, etc., to improve product quality and performance, and is widely used, highlighting its key value in many fields and injecting vitality into the development of various industries.

What I am asking you is about the market price range of dimethyl pyridine-2,5-dicarboxylate. However, the price of this substance is difficult to determine, and it is affected by many factors.
First, the price fluctuation of raw materials has a great impact on the price of dimethyl pyridine-2,5-dicarboxylate. If the price of raw materials required for its preparation rises, the price of finished products often rises; conversely, the price of raw materials falls, and the price of finished products may fall.
Second, the quality of the production process is also related to the price. Advanced and efficient production processes can reduce production costs in the market competition, or can be sold at a more affordable price; while the process is backward and the cost is high, the price will be higher.
Third, the market supply and demand situation is the key factor. If the market demand for dimethyl pyridine-2,5-dicarboxylate is strong, but the supply is limited, the price will rise; if the supply exceeds the demand, the price will inevitably fall.
Fourth, different manufacturers have different prices due to differences in brand reputation and product quality. Well-known manufacturers with high product quality may have higher prices than other factories.
According to past market conditions, the price range of dimethyl pyridine-2,5-dicarboxylate may range from tens to hundreds of yuan per kilogram. However, this is only a rough range. The current exact price needs to be consulted in detail with relevant chemical product suppliers, trading platforms or market survey agencies to obtain accurate figures.

Dimethyl pyridine-2,5-dicarboxylate is a kind of organic compound. Its storage conditions are quite important, which is related to the quality and stability of this substance.
When storing this substance, the first environment is drying. Moisture can easily lead to adverse reactions such as hydrolysis, resulting in quality deterioration. Therefore, it should be placed in a dry place, such as a dryer, or in a storage place with a desiccant to remove moisture from the environment.
The temperature should be appropriate. Excessive temperature can promote the rate of chemical reactions to increase, causing decomposition and deterioration; too low temperature, although it may slow down the reaction, may have changes in crystallization and solidification, affecting the use and properties. Generally speaking, it should be stored in a cool place with a temperature of 2-8 ° C, which can ensure the relative stability of its chemical properties.
Furthermore, this substance should be avoided from contact with strong oxidants, strong acids, strong bases, etc. These substances are prone to chemical reactions with dimethyl pyridine-2,5-dicarboxylate, which can damage its structure and properties. When storing, it must be isolated from such substances, stored separately, and stored in a suitable container.
As for containers, corrosion-resistant materials should be selected. Glass containers are often a good choice because of their stable chemical properties and have little effect on dimethyl pyridine-2,5-dicarboxylate. However, in case of special conditions, plastic containers can also be used, but it must be ensured that they do not react with the compound.
The place where it is stored should also be well ventilated. Good ventilation can prevent the accumulation of harmful gases, reduce safety risks, and allow the gas in the storage environment to flow smoothly, which is conducive to maintaining a suitable temperature and humidity.
In short, to properly store dimethyl pyridine-2,5-dicarboxylate, it is necessary to keep it in a dry, cool and ventilated place, avoid contact with incompatible objects, and choose an appropriate container, so as to ensure the stability of its quality and properties for subsequent use.