Pyrazolo 1 5 A Pyridine 2 Carboxylic Acid
pyridine pyrrole pyrazine piperidine piperazine

Pyrazolo[1,5-a]pyridine-2-carboxylic acid

    Specifications

    HS Code

    728799

    Chemical Formula C8H6N2O2
    Molar Mass 162.146 g/mol
    Appearance Solid (usually white or off - white)
    Physical State At Room Temp Solid
    Melting Point Data may vary, typically in a certain range (e.g., 200 - 250°C approximately, exact value depends on purity)
    Solubility In Water Low solubility, sparingly soluble
    Solubility In Organic Solvents Soluble in some polar organic solvents like DMSO, DMF
    Pka Value The acidic hydrogen on the carboxylic acid group has a pKa value (approximate range could be 3 - 5)
    Crystal Structure Specific crystal structure determined by X - ray crystallography studies
    Odor Odorless or very faint odor
    Stability Stable under normal conditions, but may react with strong oxidizing or reducing agents

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    Frequently Asked Questions

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    What are the main uses of pyrazolo [1,5-a] pyridine-2-carboxylic acids?
    To [1,5-a] to its-2-naphthoic acid, what is the main use of this product?
    to its-2-naphthoic acid, is an important use. In the field of materials science, it is often synthesized into special polymer materials. This polymer material can have excellent physical properties, such as high hardness, chemical corrosion resistance, etc., so it is used in aerospace, automotive manufacturing and other industries.
    In the process of research and development, it also has extraordinary properties. Due to the special characteristics of molecules, it can be used as a key ingredient in the active ingredients of chemicals. Synthetic compounds based on this basis, or have the effect of specific diseases, such as some anti-cancer compounds, can be used for therapeutic purposes through their special cellular action.
    Furthermore, in the field of optical materials, to [1,5-a] to its-2-naphthoic acid can be used to improve the special optical properties of the material. If used in optical diodes (OLEDs), it can improve its optical efficiency and chromaticity, making the display a more realistic surface, and promote the development of optical properties.
    Therefore, to promote the transformation of [1,5-a] to its-2-naphthalic acid with its characteristics, it plays an indispensable role in many important domains, and promotes the innovation of many technologies.
    What are the physicochemical properties of pyrazolo [1,5-a] pyridine-2-carboxylic acids
    This is an organic compound whose physicochemical properties are particularly important and related to applications in many fields. Although "Tiangong Kaiwu" does not directly describe this object, the wisdom of the ancients in the exploration of the properties of chemical substances can be deduced slightly from relevant experience.
    In terms of physical properties, the [1,5-a] and the - 2-naphthalenecarboxylic acid may have a specific form. At room temperature, it is either solid, looking at its appearance, or crystalline powder, with a certain luster. Its color may be almost colorless to slightly yellow, which has a specific performance on light absorption and reflection due to the characteristics of molecular structure. Its melting point is quite critical. It has been determined by modern research that it is about a certain temperature range. This temperature changes the intermolecular force and causes the substance to change from solid to liquid. And this substance has different solubility in common organic solvents. In some polar organic solvents such as ethanol and acetone, it may have a certain solubility. Due to the interaction between molecular polarity and solvents, but in non-polar solvents such as n-hexane, the solubility may be very low.
    Discussing chemical properties, the carboxylic group is reactive to the [1,5-a] and its-2-naphthalene carboxylic acid. Carboxylic groups are acidic and can neutralize with bases to generate corresponding salts and water. For example, when reacted with sodium hydroxide to form sodium salts, this reaction reflects its acidic properties. And the carboxyl group can participate in the esterification reaction, and the alcohol is dehydrated under the action of a catalyst to form an ester compound. This reaction is commonly used in organic synthesis and can construct complex organic molecular structures. In addition, the naphthalene ring part of the molecule has certain stability. However, under specific conditions, such as the action of a strong oxidant or an oxidation reaction, the structure of the naphthalene ring may be destroyed, resulting in oxidation products and changes in chemical properties.
    What are the synthesis methods of pyrazolo [1,5-a] pyridine-2-carboxylic acids?
    To prepare alkynes [1,5-a] alkynes and their 2-carboxylic acids, there are many methods for synthesizing them, and each has its advantages and disadvantages. The following are the main ones.
    First, halogenated hydrocarbons are used as starting materials. The elimination reaction between halogenated hydrocarbons and strong bases in a suitable solvent can gradually build an alkyne skeleton. For example, by selecting a suitable dihalogenated hydrocarbon, first interacting with a strong base such as sodium alcohol, an elimination reaction occurs to form an olefin, and then again eliminating the formation of alkynes under stronger alkaline conditions or higher temperatures. Subsequently, by reacting alkynes with carbon dioxide under specific conditions, carboxyl groups can be introduced to produce the target 2-carboxylic acid. The raw materials of this method are relatively easy to obtain, and the reaction conditions are relatively conventional, but the steps are slightly complicated, and the reaction conditions of each step need to be carefully controlled to ensure the purity and yield of the product.
    Second, the nucleophilic substitution reaction of alkynes is used. Select a suitable alkyne lithium reagent or alkyne magnesium reagent, and react with the corresponding haloalkane to directly generate the target alkyne structure. After that, the alkyne is carboxylated. For example, the alkyne is converted into an aldehyde by borohydrogenation-oxidation reaction, and then further oxidized to a carboxylic acid. This method is relatively direct, but the preparation of alkyne reagents requires harsh conditions such as anhydrous and anoxic conditions, and the stability of the reagents is not good, so the operation requirements are high
    Third, the carbonyl compound is used as the starting material. For example, the condensation reaction of diethyl malonate with aldodes or ketones under basic conditions is used to construct an intermediate containing a specific structure, and then it is converted into alkynes through steps such as hydrolysis and decarboxylation. Subsequently, carboxyl groups are introduced through a series of oxidation or substitution reactions. This approach can cleverly utilize the reactivity of carbonyl compounds, but it involves multi-step reactions. The overall route is relatively complicated, and the reaction sequence and conditions are extremely controlled.
    All these synthesis methods have their own strengths and weaknesses. In practical application, it is necessary to carefully select the optimal method according to the availability of raw materials, reaction conditions, cost considerations and product purity requirements, etc., in order to efficiently synthesize the required alkynes [1,5-a] and their -2-carboxylic acids.
    In which fields are pyrazolo [1,5-a] pyridine-2-carboxylic acids used?
    Alas! In the field of application of [1,5-a] to its-2-naphthalenesulfonic acid, I will describe it now.
    To its-2-naphthalenesulfonic acid in the field of dyeing, it is effective. This compound can be used as a dye in the process of synthesizing dyes, and its special chemical production can make the dye color and color fastness is good. In the process of synthesizing dyes, its indispensable raw materials, such as cotton, hemp, and so on, can be used to dye this dye with bright color.
    Furthermore, in the field of, there are also its. Some studies have shown that it may have a certain biological activity, and it is not directly used as a chemical compound. However, in the process of chemical research, it can be used as a synthetic model. With ingenious chemical modification, or it can be derived with effective chemical molecules, which can be used to fight certain diseases, and to explore new directions in research.
    In addition, in the field of chemical analysis, to [1,5-a] to its-2-naphthalenesulfonic acid also has a place. Because it can generate specific compounds due to the inverse nature of some gold seeds, it can be used for quantitative analysis of gold seeds. With this property, it can play an important role in environmental analysis, chemical analysis, etc., and can accurately determine the content of specific gold seeds in this book.
    Therefore, to [1,5-a] to its-2-naphthalenesulfonic acid in various fields such as dyeing, dyeing, and chemical analysis, all have exhibited important application values, which is an indispensable chemical.
    What are the market prospects for pyrazolo [1,5-a] pyridine-2-carboxylic acids?


    What is the market prospect of Shanghe [1,5 - a] Shangqi-2-carboxylic acid?
    Those who Shanghe [1,5 - a] Shangqi-2-carboxylic acid have considerable prospects in the current market structure.
    Looking at its application field, this acid has attracted much attention in the field of pharmaceutical and chemical industry. The research and development of many new drugs can be used as key intermediates due to their unique chemical structures. Because of drug research and development, precise molecular structures are often sought to achieve the best pharmacological effects. The properties of this acid enable developers to build more subtle molecular frameworks for drugs, so pharmaceutical manufacturers are gradually on the rise in demand for it.
    Furthermore, in the field of materials science, commercialization and [1,5-a] commercialization of its-2-carboxylic acid have also emerged. Nowadays, materials research and development pursue high performance and multi-functionality, and this acid can participate in the synthesis of special polymer materials. The materials prepared by its participation may have better stability or excellent optical properties, which are promising in high-end fields such as electronics and aviation. It is a related material manufacturer that is paying increasing attention to it, and is expected to form a stable market demand.
    However, although the market prospect is good, there are also challenges. Its synthesis process may be complicated and cumbersome, resulting in high production costs. If there is a breakthrough in the process, cost reduction and efficiency increase, it will be able to expand market share and open up wide sales. And the competition of similar alternative products should not be underestimated. To be the leader in the market, it is necessary to continuously strengthen its own advantages, improve quality and optimize services.
    To sum up, the business and [1,5 - a] business of its - 2 - carboxylic acid market has a bright future, but it also needs to deal with many challenges. If it can be properly handled, it will be able to harvest fruitful results in the market.