Picoline Methylpyridine
pyridine pyrrole pyrazine piperidine piperazine

Picoline methylpyridine

    Specifications

    HS Code

    637329

    Chemical Formula C6H7N
    Molar Mass 93.13 g/mol
    Appearance Colorless to yellowish liquid
    Odor Pungent, pyridine - like odor
    Density 0.94 g/cm³ (approx.)
    Boiling Point 129 - 145 °C
    Melting Point -66 °C to -40 °C
    Solubility In Water Slightly soluble
    Flash Point 36 - 45 °C
    Flammability Flammable
    Vapor Pressure 1.33 kPa (20 °C, approximate)
    Refractive Index 1.506 - 1.508 (approx.)

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    General Information
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    Frequently Asked Questions

    As a leading Picoline methylpyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the chemical structure of Picoline methylpyridine?
    Picoline and methylpyridine are both English names for methylpyridine. Methylpyridine is a methyl derivative of pyridine. Its chemical structure is based on the six-membered nitrogen-containing heterocyclic ring of pyridine, and the carbon atoms on the ring are connected with methyl groups.
    The structure of pyridine is a six-membered aromatic ring in which one carbon atom is replaced by a nitrogen atom. Methylpyridine connects methyl groups at different positions (2-position, 3-position, or 4-position) of the pyridine ring, resulting in 2-methylpyridine (α-methylpyridine), 3-methylpyridine (β-methylpyridine), and 4-methylpyridine (γ-methylpyridine).
    2-methylpyridine, whose methyl group is adjacent to the nitrogen atom; 3-methylpyridine, where the methyl group is separated from the nitrogen atom by one carbon atom; 4-methylpyridine, where the methyl group is separated from the nitrogen atom by two carbon atoms. These three isomers have slightly different physical and chemical properties due to different methyl positions, but they all retain the basic chemical properties of pyridine rings, such as weak alkalinity, aromaticity, etc., and are widely used in organic synthesis, medicine, pesticides, fragrances, and many other fields.
    What are the common physical properties of Picoline methylpyridine?
    Picolin is methylpyridine. The common physical properties are as follows:
    It is a liquid with a special odor and is volatile. The boiling point is about 129-145 ° C, which varies depending on the specific isomers of methylpyridine. For example, the boiling point of 2-methylpyridine is about 129.4 ° C, the boiling point of 3-methylpyridine is about 144.1 ° C, and the boiling point of 4-methylpyridine is about 145.3 ° C.
    The relative density is about 0.94-0.96, which also varies slightly due to different isomers. Take 2-methylpyridine as an example, the relative density (20 ° C/4 ° C) is 0.9519.
    In terms of solubility, picoline can be miscible with various organic solvents such as water, alcohols, ethers, etc. It has a certain solubility in water and can dissolve many organic compounds.
    In addition, picolin has certain toxicity, and its vapor has a stimulating effect on the eyes, nose, throat and other respiratory mucosa. It needs to be handled with caution and protective measures when used. Because its chemical structure contains nitrogen heterocycles and has a certain alkalinity, it can participate in part of the reaction as a base in chemical reactions, which is also related to its physical properties.
    What are the main uses of Picoline methylpyridine in industry?
    Picolin is methylpyridine, which is widely used in industrial applications.
    First, in the field of pharmaceuticals, it is an important raw material. Many drug synthesis depends on its participation, such as some antibacterial and anti-inflammatory drugs. Taking the synthesis of a classic antibacterial drug as an example, Picolin can be converted into key intermediates through multi-step reactions, and then build the active structure of the drug to help cure diseases.
    Second, in the field of pesticides, its role should not be underestimated. It can be used to prepare insecticides, fungicides, etc. With the unique chemical properties of Picolin, compounds with efficient insecticidal and bactericidal functions can be synthesized to protect crops from diseases and insect infestations and ensure agricultural harvests.
    Third, in the dye industry, Picolin has a place. It can contribute to the synthesis of dyes with specific colors and properties. After chemical modification, it reacts with other reagents to produce dyes with bright colors and good fastness, which meet the diverse needs of dyes in textile and other industries.
    Fourth, in the field of organic synthesis, it is a commonly used reagent. Due to its nitrogen-containing heterocyclic structure, it can participate in many organic reactions, such as nucleophilic substitution, oxidation, etc., providing an effective path for the synthesis of complex organic compounds and promoting the development of organic synthesis chemistry.
    In short, Picolin has important uses in many aspects of industry and is of great significance to the development of related industries.
    How to prepare Picoline methylpyridine
    Fupicoline and methylpyridine are actually different names of the same substance, and both refer to methylpyridine. The preparation method is roughly as follows:
    First, it is obtained by separating the pyridine base fraction of coal tar. Coal tar contains a variety of pyridine compounds, and pyridine, methylpyridine, etc. can be separated through various steps such as rectification. This is a traditional method, which has been used in ancient times, but the purity of the obtained product may not be sufficient, and the process is complicated, and it needs to be refined many times.
    Second, aldehyde, ammonia, alcohol, etc. are used as raw materials and synthesized by catalytic reaction. If acetaldehyde and ammonia react under the action of a catalyst, methylpyridine can be obtained. In this process, the choice of catalyst is crucial, and an excellent catalyst can improve the reaction rate and product selectivity. This method can precisely regulate the reaction conditions, and the product purity is also high, but the reaction equipment and technical requirements are quite strict.
    Third, it is prepared by the conversion of heterocyclic compounds. For example, some nitrogen-containing heterocyclic compounds can be converted into methylpyridine through specific chemical reactions. This approach requires a deep understanding of the reaction mechanism in order to be effectively implemented. However, if used properly, another approach may be found to obtain an efficient preparation method.
    All these preparation methods have advantages and disadvantages. In practical applications, only by carefully selecting the appropriate method according to the purity, yield, cost and many other factors of the desired product can the purpose of preparation be achieved.
    Picoline methylpyridine during use
    Both picoline and methylpyridine are English expressions of methylpyridine. There are many precautions during use, which cannot be ignored.
    First, this substance is toxic and harmful to the human body. If it comes into contact with the skin, rinse with plenty of water immediately, and seek medical treatment as soon as possible without delay. If you inhale accidentally, you should leave the scene as soon as possible and go to a fresh air place. If you have breathing difficulties, you must give oxygen and seek medical attention in time. If you eat it by mistake, it is more serious. You must immediately urge vomiting and send to the hospital for first aid.
    Second, methylpyridine is flammable, and fireworks are strictly prohibited in the use site. Store away from fire and heat sources, and keep good ventilation to prevent the risk of explosion caused by vapor accumulation.
    Third, because of its lively chemical properties, it is easy to react with many substances. When using, it is necessary to carefully consider other chemical substances in contact with it to avoid dangerous reactions due to improper mixing. Before use, when the relevant chemical reactions are fully understood, strictly follow the operating procedures.
    Fourth, during use, protective measures are essential. Appropriate protective equipment must be worn, such as protective glasses, gloves and protective clothing, to avoid direct contact with the damage. At the same time, the operation should be carried out in a fume hood to effectively prevent steam inhalation.
    Fifth, after use, the disposal of the remaining methyl pyridine should not be ignored. It should be properly disposed of in accordance with relevant regulations, and must not be dumped at will to avoid pollution to the environment. The container containing this item should also be properly disposed of to ensure safety.