oxazolo[4,5-b]pyridine, 2-methyl-

The chemical structure of "oxazolo [4,5 - b] pyridine, 2 - methyl -" needs to be studied in detail. Here "oxazolo" means oxazolo, indicating that the structure contains the characteristics of an oxazolo ring. "[4,5 - b]" refers to the combination of the oxazolo ring and the pyridine ring. The 4th and 5th positions of the oxazolo ring are connected to the b position of the pyridine ring. And "pyridine" is the pyridine ring. "2 - methyl -" indicates that there is a methyl substitution at the 2nd position of the oxazolo-pyridine structure.
According to the ancient classical style of "Tiangong Kaiwu", the structure description is roughly as follows: This compound is formed by combining the oxazolo ring with the pyridine ring to form its skeleton. The specific position of the oxazolo ring is named with the pyridine ring according to a specific rule, which is similar to tenon and mortise. And in the second position of the combined structure, add a methyl group. The methyl group, the base of carbon-hydrogen three, is also attached to the main structure, such as branches and leaves born in the trunk.
In this way, the chemical structure of "oxazolo [4,5 - b] pyridine, 2 - methyl -" is the main body of oxazolo-pyridine, and the two positions have the appearance of methyl modification.

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The chemical structure and properties of oxazolo [4,5 - b] pyridine, 2 - methyl - need to be studied in detail.
This compound has a unique structure, which is formed by fusing oxazolo ring and pyridine ring, and has methyl substitution at the 2 position. Its physical properties, first of all, in terms of appearance, at room temperature, it is mostly in a solid state, and the color may be white to light yellow powder, which is caused by the intermolecular arrangement and crystal form.
When it comes to melting point, due to the interaction of intramolecular hydrogen bonds, Van der Waals forces, etc., its melting point is relatively high. The rigidity of the molecular structure and the spatial effect of methyl groups make the molecules tightly packed, and high energy is required to overcome the lattice energy before they can melt into a liquid state. The boiling point of
is also considerable. Due to the complex intermolecular forces, in addition to van der Waals forces, the interring conjugation effect strengthens the intermolecular attraction. To transform the liquid state into a gaseous state, a large amount of energy needs to be input to break the intermolecular binding.
In terms of solubility, it has good solubility in organic solvents such as ethanol and dichloromethane. Because it has both polar and non-polar parts, the polar ring structure and polar solvents can form hydrogen bonds or dipole-dipole interactions, and non-polar methyl groups can interact with non-polar solvents through Van der Waals forces. However, in water, the solubility is not good, because the overall hydrophobicity is dominant, it is difficult for water molecules to form an effective interaction with the compound, and it is dispersed in the system.
The density is determined by its molecular weight and the degree of molecular accumulation. Because of its compact structure and large molecular weight, the density is higher than that of ordinary organic small molecules.
In summary, oxazolo [4,5-b] pyridine, 2-methyl - has specific physical properties, which are derived from its unique chemical structure, which is essential for applications in chemical synthesis, materials science and other fields.

Eh, this is an organic chemical substance, called 2-methyl-oxazolo [4,5-b] pyridine. Its common uses are quite complex.
In the field of medicinal chemistry, it is often a key building block for the creation of new drugs. The skeleton of Geinoxazolo-pyridine has unique spatial structure and electronic properties, which can closely fit specific targets in organisms. For example, it can be designed as an inhibitor targeting a certain type of disease-related protein kinase. By precisely acting on the activity check point of the kinase, it blocks abnormal signal transduction pathways to achieve the purpose of treating diseases such as tumors and inflammation.
In materials science, it also has good performance. Due to the particularity of its structure, it can be used to prepare materials with unique photoelectric properties. It can be used as an organic Light Emitting Diode (OLED) material, because its molecular structure can effectively regulate the luminous efficiency and color purity, contributing to the progress of display technology. Or it can be used to prepare chemical sensors, using its selective recognition ability of specific molecules or ions to achieve sensitive detection of harmful substances in the environment or important biomarkers in vivo.
Furthermore, in the field of organic synthetic chemistry, 2-methyl-oxazolo [4,5-b] pyridine is often used as an important intermediate. With its activity check point, more complex organic molecular structures can be constructed through various organic reactions, such as nucleophilic substitution, electrophilic addition, etc., providing a powerful tool for organic synthesis chemists to expand molecular diversity.

To prepare 2-methyl-oxazolo [4,5-b] pyridine, there are many ways to synthesize it, and a number of common methods can be selected.
First, it can be obtained by cyclization of nitrogen-containing heterocyclic precursors. First, take a suitable pyridine derivative, whose side chain must contain an appropriate functional group, such as a group that can react with ortho-sites to form rings. Take a pyridine compound, which is connected with a substituent that can close the ring under specific conditions, and add a specific base, such as potassium carbonate, to a suitable reaction medium, such as an aprotic polar solvent, such as N, N-dimethylformamide (DMF), to assist the reaction. When heated to a certain temperature, nucleophilic substitution and other reactions occur in the molecule, and the ring is gradually formed, then the target product 2-methyl-oxazolo [4,5-b] pyridine is obtained.
Second, it can also be constructed in a multi-step reaction. First, the oxazole ring part is constructed from simple raw materials, such as selecting appropriate carboxylic acid derivatives and ammonitrile derivatives, and condensing under the action of dehydrating agents such as dicyclohexyl carbodiimide (DCC) to form oxazole ring intermediates. Then, this intermediate is connected to the pyridine derivative, and the coupling reaction catalyzed by transition metals can be used, such as the cross-coupling catalyzed by palladium. Palladium catalysts, ligands such as triphenylphosphine, and bases such as sodium carbonate are added to the reaction system, and the reaction is heated in an organic solvent such as toluene, so that the two are connected and further cyclized to form 2-methyl-oxazolo [4,5-b] pyridine.
Third, from another perspective, pyridine and nitrogen-containing heterocycles can be used as starting materials, and the functional group transformation and cyclization can be carried out synergistically. Take the pyridine heterocyclic with suitable substituents, use its activity check point, under acidic or basic conditions, add reagents that can introduce methyl groups and promote the formation of oxazole rings, such as methylation reagent iodomethane, etc., and control the reaction conditions. The methylation and cyclization reactions occur simultaneously to achieve the purpose of synthesizing 2-methyl-oxazolo [4,5-b] pyridine. Various synthesis methods have their own advantages and disadvantages, and they need to be carefully selected according to the availability of raw materials, the difficulty of reaction, and the high or low yield.

Eh, Fu 2-methyl-oxazolo [4,5-b] pyridine, has unique characteristics in chemical reactions. It has a unique structure, which endows it with diverse reactivity.
Looking at its chemical activity, the synergistic effect of oxazolo-pyridine ring system and methyl makes it quite active in nucleophilic substitution reactions. The power supply of methyl groups can change the electron cloud density distribution on the ring, making specific locations more vulnerable to attack by nucleophiles. For example, under suitable conditions, certain carbon atoms on the ring can react with nucleophiles such as alcohols and amines to generate novel compounds.
Furthermore, in the oxidation reaction, 2-methyl-oxazolo [4,5-b] pyridine also has a unique performance. The methyl group can be selectively oxidized, or the oxazolo-pyridine ring may also be oxidized to form various oxidation products, depending on the oxidant used in the reaction and the reaction conditions.
In addition, it may also play a special role in catalytic reactions. Due to its structural properties, it can be used as a ligand to coordinate with metal ions to form catalytically active complexes, which can then catalyze a variety of organic reactions, such as carbon-carbon bond formation reactions.
Due to the rigidity of the molecule and the specific electronic structure, 2-methyl-oxazolo [4,5-b] pyridine may absorb light of specific wavelengths in some photochemical reactions, triggering reactions such as intra-molecular rearrangement and cyclization, providing a different way for organic synthesis. In short, 2-methyl-oxazolo [4,5-b] pyridine shows active and diverse characteristics in chemical reactions due to its unique structure, which brings many possibilities to the field of chemical synthesis.