N-Methylpyridine-3-methanamine

N-Methylpyridine-3-methanamine is one of the organic compounds. To clarify its chemical structure, its naming rules should be analyzed in detail. "N-Methyl" indicates that the nitrogen atom is connected with a methyl group; "pyridine" is a pyridine ring, which is a six-membered nitrogen-containing heterocyclic structure and has aromatic properties; "3-methanamine" refers to the 3-position connection of the pyridine ring with a methylamine group (- CH ² NH ²).
Therefore, its chemical structure is based on the pyridine ring as the core. At the third carbon atom of the pyridine ring, a methylene (-CH 2O -) is connected through a carbon-carbon single bond, and the methylene is then connected to the amino group (-NH 2O), and there is another methyl substitution on the nitrogen atom of the pyridine ring. Its structural abbreviation or can be written as:

CH-N (C H N - 3 - CH ² NH ³)
This structure endows the compound with unique chemical properties, which may have its uses in organic synthesis, medicinal chemistry and other fields. The interaction of methyl groups, pyridine rings and methylamino groups on the nitrogen atom allows the compound to participate in a variety of chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc., depending on the reaction conditions and the characteristics of the reactants.

N-methylpyridine-3-methylamine is one of the organic compounds. Its physical properties, first of all its properties, are mostly liquid under normal conditions, and it is clear and fluid in appearance. This is due to the characteristics of intermolecular forces.
As for its melting and boiling point, the melting point is low, resulting in it remaining liquid at room temperature. The boiling point varies according to external pressure. Under standard atmospheric pressure, the boiling point is in a specific temperature range, which is closely related to the relative mass of the molecule and the strength of intermolecular interactions. In addition to van der Waals force, there may be weak hydrogen bonding between molecules, which also affects the melting and boiling point.
In terms of solubility, the substance has good solubility in organic solvents, and common organic solvents such as ethanol and ether can dissolve with it. Due to the principle of "similar miscibility", its molecular structure has a certain polarity, which is similar to the polarity of organic solvent molecules, so it can dissolve with each other. However, in water, the solubility is relatively limited, because the polarity of water is strong, and the molecular polarity matching of the compound is not perfect. Although there are certain polar groups that can interact with water, the overall solubility is difficult to match that of strongly polarized substances.
Its density may be different from that of water, and the specific value depends on accurate measurement. The density difference is due to the degree of close accumulation of molecules and the type and quantity of atoms. Its odor may have a special smell, because the molecular structure contains heteroatoms such as nitrogen, resulting in a unique smell, but the odor description or your mileage may vary.
In summary, the physical properties of N-methylpyridine-3-methylamine lay the foundation for its application in chemical and pharmaceutical fields, and researchers can use it rationally according to its properties.

N-methylpyridine-3-methylamine, the common method for preparing this substance, multiple paths. One is to use pyridine-3-formaldehyde as the starting material to make it react with methylamine under moderate temperature and pressure. In this process, suitable catalysts are required to help, common metal catalysts such as platinum, palladium or nickel, or reducing reagents such as sodium borohydride and sodium cyanoborohydride, to promote the condensation and hydrogenation of carbonyl and amine groups to produce the target product.
Another method, starting from pyridine-3-carboxylic acid, first through esterification to obtain pyridine-3-carboxylic acid ester, and then let it react with methylamine to obtain pyridine-3-carboxylamide, and then use a strong reducing agent, such as lithium aluminum hydride, for deep reduction, which can also achieve the purpose of preparing N-methylpyridine-3-methylamine.
Furthermore, if pyridine is used as the starting material, the halogen atom is introduced at its 3-position first, such as 3-halogenated pyridine obtained by halogenation reaction, and then the product can be prepared gradually with methylamination reagents, such as methylamine halides, in the presence of bases, through nucleophilic substitution reaction. Each method has its advantages and disadvantages, depending on the availability of raw materials, reaction conditions, product purity and many other factors, to determine the most suitable method.

The preparation method of N-methylpyridine-3-methylamine has been done in many ways in the past. First, pyridine-3-formaldehyde is used as the beginning, and it is first condensed with methylamine, and then the target product is obtained by using reducing agents such as sodium borohydride or lithium aluminum hydride. In this way, the condensation reaction must be sufficient to make pyridine-3-formaldehyde and methylamine into imine intermediates, and then the reduction step can be smooth to obtain N-methylpyridine-3-methylamine with high yield. < Br >
There is also a reaction based on 3- (chloromethyl) pyridine hydrochloride with methylamine in an appropriate solvent, such as alcohols, by heating. Among these, the properties of the solvent and the control of temperature are the key. Alcohol solvents not only facilitate the dissolution of the reactants, but also help the reaction to proceed. However, if the temperature is too high, side reactions will occur, resulting in impure products. Therefore, precise temperature control is required to ensure that the reaction is directed towards the formation of N-methylpyridine-3-methylamine.
It also starts with pyridine-3-formic acid, first converts to acid chloride, then reacts with methylamine to form an amide, and finally reduces the amide through lithium aluminum hydride to obtain N-methylpyridine-3-methylamine. This path step is slightly complicated, but the reaction selectivity of each step is good. If the operation is appropriate, high-purity products can also be obtained. In the meantime, the reaction conditions of acylation, the time and dose of amide reduction are all factors that affect the quality and yield of the product.
All kinds of preparation methods have their own advantages and disadvantages. In practice, when the availability of raw materials, equipment, cost calculation and other factors are selected, the purpose of preparing N-methylpyridine-3-methylamine can be achieved.

N-methylpyridine-3-methylamine is also an organic compound. When storing and using, many things must be observed.
First word storage. This compound should be placed in a cool, dry and well-ventilated place. Because of the cool environment, it can reduce the risk of chemical reactions caused by excessive temperature. In a dry place, it can avoid contact with water vapor to prevent moisture decomposition or initiate reactions such as hydrolysis. Well-ventilated, it can avoid the accumulation of harmful gases and ensure the safety of the storage environment. And it needs to be kept away from fire and heat sources. Open flames and hot topics can cause it to burn or even explode, which is a big taboo. At the same time, it should be stored separately from oxidants, acids, etc. If they encounter them, they are prone to violent reactions and endanger safety.
As for use, be sure to strictly follow the operating procedures. Users use appropriate protective equipment, such as protective glasses, to protect their eyes from possible splashing damage; gas masks, which can prevent their volatilized gas from entering the body, to ensure the safety of the respiratory system; protective gloves, to prevent skin contact. It is especially important to operate in a fume hood, so that volatile gases can be discharged in time, reducing the concentration in the air, and reducing the risk of operator exposure. During use, there must be no open flame or smoking. The operating environment requires good electrical explosion-proof facilities. Because the compound vapor mixes with air, it can cause combustion and explosion in case of open flame and high heat energy. After use, properly dispose of the residue, do not dump it at will, and send it to a special treatment place in accordance with relevant regulations to avoid polluting the environment.