N-Methyl-4-(4-aminophenoxy)pyridine-2-carboxamide

This is an organic compound, or its Chinese name is N-methyl-4- (4-aminophenoxy) pyridine-2-formamide. Looking at its name, its chemical structure can be deduced.
Its structure contains a pyridine ring, the second position of the pyridine ring is connected to a formamide group, and the formamide group is - CONHCH. This structure has amide characteristics. The amide bond can participate in a variety of reactions, or affect the chemical activity and physical properties of the compound.
The fourth position of the pyridine ring is connected to a 4-aminophenoxy group, and the 4-aminophenoxy group is connected to an oxygen group by a phenyl ring. The 4-aminophenoxy group of the phenyl The benzene ring is aromatic and stable in nature, and the amino group is the power supply group, which can affect the electron cloud density of the benzene ring and make the benzene ring more prone to electrophilic substitution.
This structure endows the compound with unique chemical and physical properties, and may have important applications in organic synthesis and medicinal chemistry. It can be used as a synthetic intermediate to participate in the construction of more complex organic molecules, or due to specific structures and activities, it has potential pharmacological activity and becomes a lead compound for the development of new drugs.

N-methyl-4- (4-aminophenoxy) pyridine-2-formamide is an organic compound. It has a wide range of uses and plays a significant role in the field of pharmaceutical research and development.
In pharmaceutical chemistry, such compounds are often key intermediates. Its unique structure can be chemically modified to derive many biologically active substances. For example, it can be modified to fit the structure of a specific receptor, and then it is expected to become a potential drug for the treatment of specific diseases. Studies have shown that compounds containing similar structures or having affinity for certain disease-related targets can be used to regulate physiological processes and have positive therapeutic significance for diseases.
Furthermore, in the field of materials science, it may also have potential uses. Because of its special chemical structure, it may endow materials with specific properties, such as affecting the electronic and optical properties of materials. Although the application research in this area is still in the early stage, due to its structural properties, it may emerge in the development of new functional materials in the future.
In the field of organic synthesis, N-methyl-4- (4-aminophenoxy) pyridine-2-formamide can be used as a starting material or a key reagent. Chemists can use various organic reactions to build more complex organic molecular structures, expand the types and functions of organic compounds, and contribute to the development of organic synthetic chemistry.

To prepare N-methyl-4- (4-aminophenoxy) pyridine-2-formamide, the method is as follows:
First, 4-hydroxypyridine-2-formic acid is used as the starting material, and dichlorosulfoxide is co-heated to obtain 4-chloropyridine-2-formyl chloride. This step requires careful temperature control in a fume hood, because dichlorosulfoxide is highly corrosive and irritating. < Br > times, 4-chloropyridine-2-formyl chloride is reacted with methylamine to obtain N-methyl-4-chloropyridine-2-formamide. This reaction should be carried out at a low temperature, such as 0-5 ° C, in an organic solvent such as dichloromethane. Slowly add methylamine to prevent side reactions.
Furthermore, N-methyl-4-chloropyridine-2-formamide and 4-aminophenol are heated and stirred in an alkaline environment, such as the presence of potassium carbonate, with N, N-dimethylformamide as a solvent. This process requires strict monitoring of the reaction process, which can be observed by thin-layer chromatography.
After the reaction is completed, after post-treatment, such as reduced pressure distillation to remove the solvent, recrystallization with a suitable solvent, or separation and purification by silica gel column chromatography, pure N-methyl-4- (4-aminophenoxy) pyridine-2-formamide can be obtained. Each step of the reaction requires careful characterization of the raw materials and intermediates, such as nuclear magnetic resonance, mass spectrometry, etc., to confirm its structure and purity, and to ensure that the synthesis is correct.

N - Methyl - 4 - (4 - aminophenoxy) pyridine - 2 - carboxamide is an organic compound. Looking at its physical properties, first of all, its properties, under room temperature and pressure, or white to white crystalline powder, this state is easy to observe and distinguish. Its melting point is also an important physical property, about a specific temperature range, this value is of great significance for the identification and purification of the compound. Its purity can be preliminarily determined by melting point determination.
Furthermore, when it comes to solubility, it may be slightly soluble in solvents such as ether in common organic solvents, but relatively better in polar solvents such as dimethyl sulfoxide (DMSO). This solubility characteristic is crucial in fields such as drug development, and it is related to its dispersion and dissolution during the preparation process.
In addition, although the density of this compound is not precisely given in the literature, it is speculated that it should be within a reasonable range based on the same type of structural compound. The density value affects the storage, transportation and behavior of materials in certain reaction systems. At the same time, its stability is also worthy of attention. In the conventional environment, if there is no special factor interference, the chemical properties are relatively stable, but under extreme conditions such as high temperature, strong acid and alkali, structural changes and chemical reactions may occur. < Br >
The physical properties of this compound lay the foundation for the study of its chemical behavior, preparation process and practical application, and are of great value in many fields such as organic synthesis and medicinal chemistry.

N-methyl-4- (4-aminophenoxy) pyridine-2-formamide, when using, there are a number of things to pay attention to and need to be treated with caution.
Bear the brunt, safety must not be ignored. This material may have specific chemical activities, and safety procedures must be followed when using it. When handling, protective equipment is indispensable, such as gloves, goggles, etc., to prevent it from touching the skin and eyes and causing damage to the body. And it needs to be operated in a well-ventilated place to prevent its volatile aerosol from being inhaled and damaging the respiratory system.
Furthermore, its chemical properties also need to be studied in detail. When mixed with different substances, there may be a chemical reaction or an unexpected change. Therefore, before use, when it is clear about its compatibility with surrounding substances, do not mix unknown objects at will, so as to avoid danger, such as explosion, fire and so on.
Storage is also the key. It should be placed in a dry, cool and dark place, away from fire and heat sources. If it is improperly stored, it may cause it to deteriorate, lose its original effectiveness, and even risk safety.
The accuracy of weighing and usage cannot be ignored. According to the needs of experiment or production, accurate measurement, excessive or small amounts, can affect the final effect. When measuring, use precise equipment to ensure that the dosage is correct.
In addition, the waste generated during use should not be discarded at will. It needs to be properly disposed of in accordance with relevant regulations to prevent pollution to the environment.
In short, when using N-methyl-4- (4-aminophenoxy) pyridine-2-formamide, all details must be treated with care to ensure safety and proper use.