N'-HYDROXYPYRIDINE-3-CARBOXIMIDAMIDE

N '-hydroxypyridine-3-formamidine, an organic compound, has a wide range of main uses and is especially important in the field of medicinal chemistry.
In the process of drug development, N' -hydroxypyridine-3-formamidine is often used as a key intermediate. The structure of Geinpyridine and formamidine gives it unique chemical properties and biological activities. With these properties, it can be modified and constructed through various chemical reactions, paving the way for the creation of new drugs. Many studies have shown that compounds containing this structure may have antibacterial, anti-inflammatory, anti-tumor and other pharmacological activities. In terms of antibacterial, it can interfere with bacterial physiological processes and inhibit their growth and reproduction by specific mechanisms; in terms of anti-tumor, it can regulate tumor cell signaling pathways and induce tumor cell apoptosis.
In the field of organic synthesis, N '-hydroxypyridine-3-formamidine is also an important cornerstone. It can participate in many reactions, such as nucleophilic substitution, cyclization, etc. Borrowing nucleophilic substitution can introduce different functional groups and expand the structural diversity of compounds; while cyclization can build unique cyclic structures, which are often indispensable in the total synthesis of natural products and the preparation of functional materials. Due to its active reactivity and structural modifiability, organic chemists can build novel and functional organic molecules with this.
In summary, N '-hydroxypyridine-3-formamidine plays a key role in the fields of medicine and organic synthesis due to its unique structure and activity, and has made significant contributions to the development of related fields.

N '-hydroxypyridine-3-formamidine is an organic compound with unique chemical properties and important uses in many fields.
It is basic. Due to its structure containing nitrogen atoms, it can accept protons and react with acids to form salts under suitable conditions. This property is of great significance in drug synthesis. After salt formation, it may improve the solubility and stability of drugs, and facilitate drug absorption and delivery.
It is also nucleophilic. N' -hydroxypyridine-3-formamidine contains heteroatoms such as nitrogen and oxygen, which can attack electron-deficient substrates and initiate nucleophilic substitution or addition reactions. In organic synthesis, by virtue of nucleophilicity, it can react with halogenated hydrocarbons, carbonyl compounds, etc., to construct new carbon-nitrogen or carbon-oxygen bonds and synthesize complex organic molecules.
Stability is also an important property. Although relatively stable, under certain conditions, such as strong acids, strong bases or high temperature environments, the structure may change. At high temperatures, decomposition reactions may occur to form small molecule substances such as pyridine and ammonia; under acid-base catalysis, or hydrolysis reactions may be initiated, amide bonds are broken to form corresponding acids and amines.
In addition, the compound has the ability to coordinate. With nitrogen and oxygen atoms, it can coordinate with metal ions to form metal complexes. This complex is widely used in the field of catalysis, such as some metal complexes can be used as catalysts to accelerate the process of organic reactions, showing high activity and selectivity.
N '-hydroxypyridine-3-formamidine has unique chemical properties and is a key raw material and intermediate in pharmaceutical chemistry, organic synthesis, materials science and other fields. With the deepening of research, its application prospects will be broader.

This is the synthesis method of N '-hydroxypyridine-3-formamidine described above.
To prepare N' -hydroxypyridine-3-formamidine, a common method is to use pyridine-3-formonitrile as the starting material. Pyridine-3-formonitrile is first reacted with hydroxylamine salts, such as hydroxylamine hydrochloride, in the presence of suitable bases, such as potassium carbonate, in organic solvents such as methanol or ethanol. The action of the base is to convert the hydroxylamine salt into free hydroxylamine, and then undergo nucleophilic addition reaction with pyridine-3-formonitrile.
When reacting, the temperature and reaction time need to be controlled. In general, the reaction mixture can be heated to a moderate temperature, such as 50-80 degrees Celsius, and the reaction can range from several hours to ten hours, depending on the specific situation. In this process, the cyanyl group of pyridine-3-formonitrile reacts with hydroxylamine to gradually generate N '-hydroxypyridine-3-formamidine.
After the reaction is completed, the product can be separated and purified by various means. For example, column chromatography is used, silica gel is used as the stationary phase, and a suitable eluent, such as a mixed solvent of petroleum ether and ethyl acetate, is selected. The separation of the product is achieved according to the difference in the partition coefficient between the product and the impurities in the stationary phase and the mobile phase. Or use the recrystallization method to select a suitable solvent, such as ethanol, water or a mixed solvent of the two, to crystallize and precipitate the product from the solution to remove impurities and obtain pure N '-hydroxypyridine-3-formamidine.
In addition, there are other synthesis paths. If pyridine-3-formic acid is used as the starting material, it can be converted into the corresponding acid chloride first, and then reacted with hydroxylamine to obtain the target product. However, this path step is slightly complicated, and attention should be paid to the conditions of each step of the reaction and the control of side reactions.
In short, the synthesis of N '-hydroxypyridine-3-formamidine requires the selection of suitable raw materials and methods according to the actual situation, and the precise control of the reaction conditions to achieve the purpose of efficient and high-purity synthesis.

I look at your question, but I am inquiring about the price of "N -HYDROXYPYRIDINE-3-CARBOXIMIDAMIDE" in the market. However, the price of this product often varies according to the time, place, quality and supply and demand of the city, and it is difficult to have a fixed number.
I have heard that the market in ancient times was easy, but the price of the product is not static. Such as the genus of pearl jade, in prosperous cities and remote places, the price may be far from the same. In today's world, although trade is convenient, the price of this chemical product also has many variables.
If it is in the ordinary pharmaceutical market, the price may be determined by its purity. Those with high purity will be expensive; those with less, the price will be slightly reduced. Or because of the difficulty of production, if the preparation requires exquisite methods and rare materials, the price is not cheap. And the origin is different, and the transportation cost also causes the price to fluctuate.
The supply and demand of the city is especially important. If there are many people who need it, but there are few producers, the price will rise; if the supply exceeds the demand, the price may fall. As for the exact price, it is difficult to determine, and it is necessary to study the market conditions at that time and visit various merchants to obtain a rough idea. Or inquire about those who specialize in chemical products, or get something.

N '-HYDROXYPYRIDINE -3 -CARBOXIMIDAMIDE is a chemical substance. When using it, many things need to be paid attention to.
First, safety is paramount. This substance may be potentially harmful, such as contact with the skin or inhalation of its dust mist, which may damage health. Therefore, when using it, be sure to wear appropriate protective equipment, such as gloves, anti-goggles, masks, etc., to prevent direct contact with it and ensure your own safety.
Second time, the operation specification. Access to this substance should be carried out in a well-ventilated place or in a fume hood to disperse possible harmful gases in time. When weighing and transferring, be sure to be precise and careful to avoid spilling, resulting in waste and pollution.
Furthermore, store it properly. It needs to be placed in a dry, cool and ventilated place, away from fire and heat sources, and avoid mixing with other substances that may react to prevent unexpected chemical reactions.
Repeat, know the properties. Have a deep understanding of the chemical properties, physical properties and reaction characteristics of the substance. In this way, the reaction conditions can be reasonably controlled during use, to ensure the smooth progress of experiments or production, and to avoid accidents caused by unknown properties.
Again, emergency response. Make and improve emergency plans in advance. In the event of unexpected situations such as spills and leaks, you can quickly follow the plan to clean up in time and reduce hazards.
At the end, the records are detailed. All details in the use process, such as dosage, reaction conditions, phenomena, etc., should be recorded in detail. This will not only help subsequent analysis and summary, but also provide strong traceability clues when problems arise. In this way, N '-HYDROXYPYRIDINE -3 -CARBOXIMIDAMIDE can be used properly to achieve the intended purpose.