N-(hydroxymethyl)pyridine-3-carboxamide

N- (hydroxymethyl) pyridine-3-formamide, this substance has a wide range of uses. In the field of medicine, it can be used as a key intermediate in drug synthesis. The characteristics of the structure of the pyridine ring and the amide give it unique chemical activity and biological activity. It can participate in the construction of various drug molecules and lay the foundation for the creation of new drugs.
In the chemical industry, it also plays an important role. Or it can be used to prepare special polymer materials. With its special structure, polymer materials can obtain specific properties, such as improving the stability and solubility of materials.
In agriculture, it may be developed into new pesticides. Through its mechanism of action on specific organisms, pest control can be achieved, and because of its structural characteristics, it may have the advantages of high efficiency and low toxicity, which is suitable for the development of green agriculture.
In addition, it is also an important raw material in the synthesis of fine chemicals. It can be derived from a variety of chemical reactions with specific functions, such as special fragrances, additives, etc., to meet the diverse needs of fine chemicals in different fields. From this perspective, N - (hydroxymethyl) pyridine-3-formamide has significant uses in many fields and plays an important role in promoting the development of related industries.

N- (hydroxymethyl) pyridine-3-formamide is also an organic compound. Its physical properties are quite important and can be viewed from many aspects.
First of all, its appearance is usually white to light yellow crystalline powder. This morphological characteristic is the primary basis for the actual identification and operation of this substance. Its texture is fine, like a powder state, and it is easy to disperse and handle.
When it comes to melting point, N- (hydroxymethyl) pyridine-3-formamide has a specific melting point range. Generally speaking, its melting point is within a certain numerical range, and this melting point characteristic can help to identify the purity of the compound. If the melting point is accurate and approaches the theoretical value, it indicates that the purity of the compound is high; if the melting point deviates, it may suggest that there are impurities mixed in.
Solubility is also a key physical property. In common organic solvents, such as ethanol and acetone, N - (hydroxymethyl) pyridine-3 - formamide exhibits different degrees of solubility. In ethanol, it can be moderately dissolved to form a uniform solution. This property is extremely important in the process of chemical synthesis and preparation. The dissolution, separation and purification of the compound can be achieved by selecting a suitable solvent.
In addition, its density is also a physical parameter. Although the density value is not a daily concern, in some specific chemical processes and experimental designs, the consideration of density is related to the measurement and mixing ratio of substances.
Furthermore, the stability of this substance also belongs to the category of physical properties. Under normal temperature and pressure, N- (hydroxymethyl) pyridine-3-formamide is relatively stable and can maintain its chemical structure and properties for a certain period of time. However, in case of extreme environments such as high temperature and high humidity, physical or chemical changes may occur, such as decomposition, deliquescence, etc.
From the above perspective, the physical properties of N- (hydroxymethyl) pyridine-3-formamide, such as appearance, melting point, solubility, density, and stability, are of great significance in chemical research, industrial production, and related applications, laying the foundation for in-depth understanding and rational use of this substance.

The chemical stability of N - (hydroxymethyl) pyridine-3 -formamide is related to many aspects and cannot be generalized.
From the structural point of view, the pyridine ring has a certain stability, due to the existence of the conjugate system. The nitrogen atom on the ring has a lone pair of electrons, which can participate in a variety of chemical reactions, but also endows a certain structural stability. The amide group is a common group in organic chemistry, and its C-N bond has some double bond properties, which is relatively strong and contributes to molecular stability. Hydroxymethyl contains an active hydroxyl group, which can participate in esterification, etherification and other reactions, which may reduce molecular stability in this regard.
In a common chemical environment, if it is in a neutral, normal temperature and dry environment, N- (hydroxymethyl) pyridine-3-formamide is relatively stable, and the chemical bonds between the atoms in the molecule are difficult to spontaneously break or rearrange. However, in the case of strong acids and strong bases, the situation changes. In strong acids, amide groups or hydrolysis form corresponding carboxylic acids and amines; under strong bases, hydroxymethyl hydroxyl groups may be deprived of protons, triggering subsequent reactions and causing molecular structure changes.
Increased temperature also affects stability. At high temperatures, the thermal motion of molecules intensifies, and the vibration of chemical bonds increases. When the energy reaches a certain level, chemical bonds may break, triggering reactions such as decomposition.
In summary, the chemical stability of N- (hydroxymethyl) pyridine-3-formamide varies according to the environment, and it can exist stably under specific mild conditions. However, under extreme conditions, the stability is poor.

The method of synthesizing N- (hydroxymethyl) pyridine-3-formamide has existed in ancient times, and it has also evolved over time. In the past, the initial method or according to the ancient law books, it required many steps and caution.
One method is to take pyridine-3-formic acid as the base and react with formaldehyde under specific conditions, such as suitable temperature, pressure and catalyst. In this reaction, the amount of formaldehyde, the temperature and pressure of the reaction are all key. If there is too little formaldehyde, the reaction may be insufficient; if there is too much, impurities will be generated. If the temperature is too high, the reaction will be too fast and difficult to control; if it is too low, the reaction will be slow and time-consuming. The choice of catalyst is also important, either acid-base or special metal complexes, which can promote the rate of reaction and increase the yield of the product.
There is another method, using pyridine as the starting material, first carboxylation to obtain pyridine-3-carboxylic acid, and then hydroxymethylation. When carboxylation, select a suitable carboxylation reagent, such as carbon dioxide, and cooperate with a suitable metal catalyst to introduce carboxyl groups into the pyridine ring under a specific environment. Then the hydroxymethylation step is followed by the previous method and reacts with formaldehyde under appropriate conditions to obtain N - (hydroxymethyl) pyridine-3-formamide.
Another way of synthesis is to start with pyridine-3-formyl chloride, first react with formaldehyde derivatives, such as hydroxymethylation reagents, and then hydrolyze and other steps to obtain the target product. In this process, the preparation of pyridine-3-formyl chloride requires rigorous operation, because its activity is quite high and it is easy to react with surrounding substances. The step of hydrolysis is also crucial to the precise control of the reaction conditions. Improper hydrolysis will affect the purity and yield of the product.
Each method has its own advantages and disadvantages, or the yield is high but the steps are complicated, or the steps are simple and the yield is poor. The synthesizer needs to carefully choose the appropriate method according to his own needs, such as the requirements for product purity, yield, experimental conditions, cost and many other factors, in order to achieve the purpose of synthesis.

N- (hydroxymethyl) pyridine-3-formamide, the price of this substance in the market is difficult to determine. The change in its price depends on multiple ends.
Watching the past, the state of market change, the supply of materials, and the number of requests are all about the price. If the material is abundant and the supply exceeds the demand, the price will stabilize; if the product is difficult, the supply is limited, and there are many seekers, the price will rise.
And the method of preparation is related to the cost. The more refined the preparation technique is, the more the cost will be reduced, and the price may be reduced; if the technique is not good, the cost will be high, and the price will also rise.
Furthermore, the change of the times, the regulations of the government, are also the influence of the price. The leniency of the decree is related to the rise and fall of the industry, and then the price is involved.
Therefore, if you want to know the exact price of N- (hydroxymethyl) pyridine-3-formamide, you must check the current market situation, consult the merchants and experts, and make a comprehensive decision. Only then can you get a near-real price. However, at present, it is difficult to determine the range of its price.