N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-h ydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-1H,6H, 7H-pyrrolo[2,3-c]pyridine-2-carboxamide

This is a blindly complex organic compound named "N-ethyl-4- [2- (4-fluoro-2,6-dimethylphenoxy) -5 - (2-hydroxypropyl-2-yl) phenyl] -6-methyl-7-oxo-1H, 6H, 7H-pyrrolido [2,3-c] pyridine-2-formamide". Its chemical structure is as follows:
- ** Core structure **: With pyrrolido [2,3-c] pyridine as the core skeleton, this is the basic structure of the compound. At position 7 of the core structure, an oxygen atom is attached to it to form a carbonyl group, the 7-oxo structure. Position 6 has a methyl group, and position 2 is connected to a formamide group. The nitrogen atom in this formamide group is connected to the ethyl group to form the N-ethyl-2-formamide moiety.
- ** Phenyl ring substituent **: Position 4 of the core structure is connected to a phenyl group. This phenyl group is substituted with 2 - (4 - fluoro - 2,6 - dimethylphenoxy) at position 2. In this substituent, the phenyl ring in the 4 - fluoro - 2,6 - dimethylphenoxy group has a fluorine atom at position 4, and a methyl group at positions 2 and 6 each, which is connected to the main phenyl group through an oxygen atom. At the same time, the position 5 of the main phenyl group is substituted with 2 - hydroxypropyl - 2 - group, which is an isopropyl structure, in which a methyl group is connected to a hydroxyl group on the carbon atom.
In summary, this compound is composed of pyrrolidine core structure, formamide group and ethyl substituent, and phenyl group containing specific substituent, and the overall structure is quite complex and delicate.

N-ethyl-4- [2- (4-fluoro-2,6-dimethylphenoxy) -5- (2-hydroxypropan-2-yl) phenyl] -6-methyl-7-oxo-1H, 6H, 7H-pyrrolo [2,3-c] pyridine-2-carboxamide is an organic compound. This compound is often used in multiple applications in the field of medicinal chemistry.
First, it may be a key intermediate for the development of new drugs. After clever chemical modification and structural optimization, drugs with specific pharmacological activities can be obtained, or they can be effective for therapeutic targets of specific diseases, such as for the treatment of some refractory diseases.
Second, in the exploration of the mechanism of drug action, its structural properties can provide key clues. Studying the interaction between them and biological macromolecules can help clarify the pathway of drug onset and lay the foundation for more precise drug design.
Third, at the level of drug synthesis process development, as an important link, in-depth research on its synthesis method can improve production efficiency, reduce costs, and promote the industrial production process of related drugs.
In addition, in the field of basic scientific research, it can be used as a tool compound to help scientists deeply explore the pathophysiological process in vivo and enhance the understanding of the basic principles of life science.

To prepare N - ethyl - 4 - [2 - (4 - fluoro - 2,6 - dimethylphenoxy) -5 - (2 - hydroxypropan - 2 - yl) phenyl] -6 - methyl - 7 - oxo - 1H, 6H, 7H - pyrrolo [2,3 - c] pyridine - 2 - carboxamide, the method is as follows:
First, all materials need to be prepared, and the reactants used, such as fluorine-containing 2,6 - dimethylphenol, pyridine derivatives with specific structures, ethylation reagents and other auxiliary reagents, need to be obtained in high purity to ensure the reaction Successful.
First take 4-fluoro-2,6-dimethylphenol, react with suitable halogenated hydrocarbons in the presence of bases, and react in organic solvents. For bases, potassium carbonate or sodium hydroxide can be used, and the organic solvent is acetonitrile or N, N-dimethylformamide. Heating at controlled temperature, the nucleophilic substitution reaction occurs between the two to obtain 2- (4-fluoro-2,6-dimethylphenoxy) halogenated benzene derivatives.
Next, the obtained derivative is coupled with a reagent containing a 2- (hydroxypropan-2-yl) structure, and a palladium-catalyzed coupling reaction is appropriate. Palladium catalysts such as tetrakis (triphenylphosphine) palladium, the ligand is suitable, in a specific solvent such as toluene, heated and stirred, so that the two are coupled to give an intermediate containing 2 - (4 - fluoro - 2,6 - dimethylphenoxy) -5 - (2 - hydroxypropan - 2 - yl) phenyl.
This intermediate is then reacted with 6-methyl-7-oxo-1H, 6H, 7H-pyrrolo [2,3-c] pyridine-2-carboxylic acid or its active derivatives, such as acid chloride or anhydride, in the presence of an organic base such as triethylamine, in a solvent such as dichloromethane, and the amidation reaction is carried out to obtain the target product precursor.
Finally, the precursor is reacted with ethylating agents, such as iodoethane, in a suitable solvent under alkali catalysis, ethyl is introduced, and purified by post-treatment, such as extraction, column chromatography, etc., to obtain N - ethyl - 4 - [2 - (4 - fluoro - 2,6 - dimethylphenoxy) -5 - (2 - hydroxypropan - 2 - yl) phenyl] -6 - methyl - 7 - oxo - 1H, 6H, 7H - pyrrolo [2,3 - c] pyridine - 2 - carboxamide. During the reaction process, it is necessary to strictly measure the reaction process, control the temperature, time and material ratio, and obtain high-purity products.

N - ethyl - 4 - [2 - (4 - fluoro - 2,6 - dimethylphenoxy) -5 - (2 - hydroxypropan - 2 - yl) phenyl] -6 - methyl - 7 - oxo - 1H, 6H, 7H - pyrrolo [2,3 - c] pyridine - 2 - carboxamide is an organic compound. Its physical and chemical properties are as follows:
In terms of view, this compound is often in a solid state, mostly white or off-white powder. Due to the intermolecular forces, it has a stable solid structure at room temperature and pressure. When it comes to the melting point, it is experimentally measured to be in a certain temperature range. This temperature is the critical temperature at which the molecule overcomes the lattice energy and converts from a solid state to a liquid state, reflecting the strength of the interaction between molecules.
In terms of solubility, it exhibits certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide. Because the molecular structure of the compound contains polar and non-polar parts, it can interact with organic solvent molecules through van der Waals forces, hydrogen bonds, etc., so it can be dissolved. However, the solubility in water is poor, because the polarity of water molecules is limited to the overall polarity matching of the compound, and some hydrophobic groups in the compound hinder its interaction with water.
The compound has good stability. Under normal temperature, dry and dark conditions, it can be stored for a long time without significant chemical changes. However, when exposed to strong acids, strong bases or high temperatures, some chemical bonds in the structure, such as amide bonds and ether bonds, may break, causing chemical reactions to form new compounds. This stability stems from the rationality of the strength of the chemical bonds in the molecule and the spatial structure.
From the perspective of spectral properties, its infrared spectrum presents specific absorption peaks, which can be used to identify functional groups in molecules, such as the stretching vibration peaks of carbonyl groups indicating the existence of amide groups. Nuclear magnetic resonance spectroscopy can reveal hydrogen and carbon atoms in different chemical environments in molecules, providing an important basis for determining molecular structure. The physical and chemical properties of this compound are closely related to its molecular structure, providing a basis for its synthesis, separation, and application.

There is a substance called N-ethyl-4- [2 - (4 - fluoro - 2,6 - dimethylphenoxy) -5 - (2 - hydroxypropan - 2 - yl) phenyl] -6 - methyl - 7 - oxo - 1H, 6H, 7H - pyrrolo [2,3 - c] pyridine - 2 - carboxamide. This substance is in the market, and the prospect is still difficult to determine.
The field of Guanfu medicine, this substance may have a unique pharmacology. Its structure is exquisite, and the groups involved may be specifically combined with biological targets in the body. If so, it is expected to become the cornerstone of new drug research and development. If it is well developed, it fits the market's demand for high-efficiency and low-toxicity drugs, or it can emerge in the treatment of specific diseases, win the trust of doctors and patients, and the market prospect may be bright.
However, there are also challenges. The road to new drug research and development is full of dangers. From laboratory to clinical application, it needs to go through many tests. In-depth exploration of pharmacological mechanisms, safety assessment, large-scale clinical trials, etc., any omission in any link can lead to failure in research and development. And the pharmaceutical market is highly competitive, and similar drugs may have seized the opportunity. If they cannot highlight their advantages, it may be difficult to stand out.
Furthermore, at the level of chemical production, the difficulty and cost of the synthesis process are all related to its market fate. If the synthesis steps are cumbersome, the raw materials are scarce and expensive, and the mass production is limited, the market supply will be insufficient, and it will be difficult to have broad prospects. Only by optimizing the process, reducing costs and increasing efficiency can we win a place in the market.
In short, N - ethyl - 4 - [2 - (4 - fluoro - 2,6 - dimethylphenoxy) -5 - (2 - hydroxypropan - 2 - yl) phenyl] -6 - methyl - 7 - oxo - 1H, 6H, 7H - pyrrolo [2,3 - c] pyridine - 2 - carboxamide in the market prospects, opportunities and challenges coexist, need to be cautious, with time, to know its rise and fall in the market.