N-Boc-4-Amino-2-bromopyridine

N - Boc - 4 - Amino - 2 - bromopyridine is a key raw material for organic synthesis. It has a wide range of uses, especially in the field of medicinal chemistry.
Bearing the brunt, it is the cornerstone of drug research and development. When creating new antibacterial drugs, N - Boc - 4 - Amino - 2 - bromopyridine can be used as a key building block. With its unique activity of pyridine ring with amino and bromine atoms, it can react with other compounds through various reactions, such as nucleophilic substitution, coupling reactions, etc., to build a complex drug molecular structure, endowing the drug with specific antibacterial activity to deal with difficult bacterial infections.
Furthermore, it also plays an important role in the exploration of anti-cancer drugs. The carefully designed organic synthesis path can be used as a starting material to derive compounds with potential anti-cancer activity. Or by modifying the surrounding groups of the pyridine ring to regulate the interaction between the molecule and the target of cancer cells, the purpose of precision anti-cancer can be achieved, and it brings new hope for the cure of cancer stubborn diseases.
In addition, in the field of materials science, it also has good performance. For example, in the process of preparing special optoelectronic materials, N-Boc-4-Amino-2-bromopyridine can participate in the construction of polymers with unique optoelectronic properties. Due to the properties of atoms and groups in the structure, polymers can endow special electronic conductivity, luminescence and other properties, and show broad application prospects in the field of cutting-edge materials such as organic Light Emitting Diode (OLED).
In short, N-Boc-4-Amino-2-bromopyridine plays an indispensable role in medicine, materials and other fields with its unique chemical structure and activity, promoting the continuous development of related science and technology.

N-Boc-4-Amino-2-bromopyridine is an important compound in the field of organic synthesis. The common synthesis methods are as follows.
One is to use 2-bromo-4-nitropyridine as the starting material. First, the nitro group on the pyridine ring is reduced, and a suitable reducing agent can be selected, such as iron/hydrochloric acid system, palladium-carbon hydrogenation, etc., to convert the nitro group into an amino group to obtain 4-amino-2-bromopyridine. Then, using Boc anhydride (di-tert-butyl dicarbonate) to protect the amino group, in the presence of suitable bases, such as triethylamine, potassium carbonate, etc., in suitable organic solvents, such as dichloromethane, N, N-dimethylformamide, N-Boc-4-Amino-2-bromopyridine can be prepared.
Second, starting from 2-bromopyridine. First, the pyridine ring is electrophilic substitution reaction, nitro is introduced, and the nitro group can be controlled to enter the 4 position by positioning rules. Then 4-amino-2-bromopyridine is reduced, and the subsequent synthesis is completed by using Boc anhydride to protect the amino group.
Third, use 4-aminopyridine as raw material. First use Boc anhydride to protect the amino group, and then introduce bromine atoms at the second position of the pyridine ring through bromination reaction. The bromination reagent can be N-bromosuccinimide (NBS), etc., and the reaction is carried out under suitable reaction conditions to obtain the target product. Each method has its own advantages and disadvantages, and the appropriate synthesis path should be selected according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product.

N-Boc-4-Amino-2-bromopyridine is a compound commonly used in organic synthesis. Its physical properties are crucial and are related to many chemical processes.
This compound is mostly solid at room temperature, and its appearance is often white to off-white crystalline powder. This form is easy to store and use, and provides convenience in experimental operations. In terms of melting point, it is about a specific temperature range, which can help identify purity. Those with high purity have a narrow melting point range and are close to theoretical values.
Solubility is also an important physical property. In common organic solvents, such as halogenated hydrocarbon solvents such as dichloromethane and chloroform, it exhibits good solubility. This allows N-Boc-4-Amino-2-bromopyridine to be uniformly dispersed in organic synthesis reactions using these solvents as the reaction medium, and to fully contact with other reactants to promote the efficient progress of the reaction. However, in water, its solubility is poor, which is due to the large proportion of hydrophobic parts in the molecular structure.
In addition, it has certain stability and can maintain the chemical structure unchanged under conventional storage conditions. However, it should be noted that contact with strong oxidants, strong acids, strong bases and other substances should be avoided to prevent chemical reactions and destroy their structures. In the field of organic synthesis, understanding and making good use of these physical properties can help design and optimize the synthesis route, and improve the yield and purity of the target product.

N-Boc-4-Amino-2-bromopyridine is a compound commonly used in organic synthesis. Its market price often fluctuates due to a variety of factors, and it cannot be generalized.
Looking at the changes in the price of chemical products in the past, the abundance of raw materials is not the main factor. If the raw materials required for the synthesis of N-Boc-4-Amino-2-bromopyridine, such as specific pyridine derivatives, Boc protection reagents and brominating agents, are in sufficient supply and affordable, the cost of the compound may be reduced, and the market price will also decrease. On the contrary, if raw materials are scarce, prices will rise.
Secondly, the difficulty of the preparation process also affects its price. If there is a new and efficient synthesis method that can reduce steps, increase yield, and reduce energy consumption, the cost will be reduced and the price will be cheap. If the process is complicated and harsh reaction conditions are required, such as high temperature, high pressure, or special catalysts, the cost will be high and the price will be high.
Furthermore, the market supply and demand is the key to the price. If many pharmaceutical companies and scientific research institutions have strong demand for N-Boc-4-Amino-2-bromopyridine, but the supply is limited, the so-called supply is in short supply, and the price will rise. If the demand is weak and the manufacturer's inventory is overstocked, it is for sales, and the price may be reduced.
In addition, differences in regions and trade policies also affect their prices. Prices may vary in different regions due to different transportation costs and tax policies. Trade barriers are high, imports are limited, and local products may have high prices due to less competition; conversely, trade is smooth, and products are flooded, and prices may be depressed.
To sum up, the market price of N-Boc-4-Amino-2-bromopyridine is actually intertwined by various factors such as raw materials, processes, supply and demand, and regional policies. To know the exact price, it is necessary to carefully consider the current market conditions.

N-Boc-4-amino-2-bromopyridine is a commonly used intermediate in organic synthesis. During storage and transportation, there are many matters to be paid attention to.
First words storage. This compound should be placed in a cool, dry and well-ventilated place. Because it is quite sensitive to humidity, if it is in a humid environment, it is easy to absorb moisture and cause deterioration, so moisture prevention is the priority. In addition, it also requires temperature. Excessive temperature can cause chemical reactions and cause structural changes. Therefore, the temperature should be controlled within an appropriate range, usually refrigerated at 2-8 ° C, but the specifics need to be determined according to its physicochemical properties and related instructions. And it needs to be stored separately from oxidizing agents, acids, alkalis and other substances to prevent dangerous reactions caused by interaction.
As for transportation, it should not be taken lightly. It is necessary to ensure that the packaging is intact to avoid leakage on the way. The transportation process should be maintained smoothly to avoid violent vibration and collision. Because its structure may contain more active groups, it should be violently vibrated or caused to react. At the same time, the temperature and humidity of the transportation environment should also be reasonably controlled, and strive to be similar to the storage conditions. Transportation personnel should be familiar with the characteristics of the chemical and emergency treatment methods. In case of emergencies, they can dispose of it quickly and properly to avoid major disasters. In this way, the safety and stability of N-Boc-4-amino-2-bromopyridine during storage and transportation can be guaranteed for subsequent organic synthesis.