N-Acetylamino-5-bromo pyridine

N-Acetamido-5-bromopyridine is one of the organic compounds. Its chemical properties are well-researched.
Discussing the physical properties, it may be a solid under normal conditions, but its specific color state varies depending on the purity and surrounding conditions. The genus of its melting point and boiling point are the key characteristics for judging this substance. The melting point is the temperature at which a substance changes from a solid state to a liquid state, and the boiling point is the critical temperature at which it is liquefied into a gaseous state. Both are crucial for the identification and separation and purification of this compound.
As for the chemical activity, both acetamido and bromine atoms in its molecular structure have unique reactivity. In the acetamide group, the nitrogen atom has a lone pair of electrons, which can be used as a nucleophilic reagent and appear in many nucleophilic substitution reactions. The bromine atom at the 5-position is active and abnormal, which is easy to be attacked by nucleophilic reagents, causing bromine to be substituted and derived from other compounds.
In an acidic and alkaline environment, it also has specific behaviors. The nitrogen atom of the acetamide group may be protonated in an acidic medium, causing changes in the charge distribution of the molecule, affecting its solubility and reactivity. When exposed to alkali, the internal chemical bonds of the molecule may be broken or rearranged.
This compound can also participate in many organic reactions, such as coupling with metal-organic reagents, through transition metal catalysis, bromine atoms are combined with metal reagents to form new carbon-carbon bonds or carbon-heteroatom bonds, which are widely used in the synthesis of complex organic molecules.
In short, the chemical properties of N-acetamido-5-bromopyridine are diverse and play an important role in various fields such as organic synthesis and pharmaceutical chemistry. According to its characteristics, scholars can apply ingenious methods to create novel and valuable compounds.

There are two common methods for preparing N-acetamido-5-bromopyridine. First, 5-bromopyridine is used as the starting material. 5-bromopyridine is first reacted with an acetylating agent, such as acetyl chloride or acetic anhydride, under suitable conditions. Among them, if acetyl chloride is used, a base is often used as an acid binding agent, such as triethylamine or pyridine, and the reaction is carried out in an organic solvent, such as dichloromethane or chloroform. During the reaction, the carbonyl group of acetyl chloride is attacked by the nucleophilic attack of the 5-bromopyridine nitrogen atom to form an intermediate. After the proton transfer and elimination steps, N-acetyl-5-bromopyridine is obtained. If acetic anhydride is used, the reaction conditions are relatively mild. Usually, the reaction can be promoted by heating and the presence of a catalytic acid, such as p-toluenesulfonic acid. The acetyl group of acetic anhydride binds to the nitrogen atom of 5-bromopyridine to form the target product.
Second, 5-bromopyridine can be prepared first, and then acetylated. With suitable raw materials, 5-bromopyridine can be obtained by multi-step reaction. For example, the corresponding halopyridine is obtained by nucleophilic substitution, reduction, etc. Then, 5-bromopyridine reacts with the acetylation reagent. This acetylation reaction is similar to the above-mentioned acetylation of 5-bromopyridine, and acetyl chloride or acetic anhydride can be selected. When acetyl chloride is used, the presence of a base is indispensable; with acetic anhydride, the catalytic amount of acid can speed up the reaction process, and finally N-acetamido-5-bromopyridine can be obtained.

N-Acetamido-5-bromopyridine, an organic compound, has important uses in many fields.
In the field of medicinal chemistry, it is often a key intermediate in the synthesis of drugs. Due to its unique structure, it has specific reactivity and biological activity, and can participate in many drug synthesis reactions. Taking antibacterial drugs as an example, by incorporating them into the molecular structure of the drug through a specific chemical reaction, the drug has better antibacterial performance and targeting, which helps the drug to act more accurately on pathogens and improve the therapeutic effect.
In the field of materials science, N-Acetamido-5-bromopyridine is also valuable. It can be used to prepare organic materials with special properties, such as optoelectronic device materials. After appropriate chemical modification and polymerization, it can have unique optical and electrical properties, which can contribute to the improvement of the performance of optoelectronic devices such as organic Light Emitting Diodes (OLEDs), making them more efficient and more colorful.
In organic synthesis chemistry, it is an important building block and participates in the construction of complex organic molecular structures. Due to its nitrogen and bromine activity check points, it can be combined with other organic compounds through halogenation reactions, nucleophilic substitution reactions and other organic reactions to expand the structural diversity of organic molecules and help chemists synthesize various novel and functional organic compounds.

In today's world, it is difficult to know the price range of N - Acetylamino - 5 - bromo + pyridine in the market. Factors such as supply and demand in the market, high quality, cost of production, and pricing strategies of merchants can all cause their prices to vary greatly.
Looking at the past, if you use the method of "Tiangong Kaiwu" to speculate, the price of materials often changes from time to time and varies from place to place. The same is true for chemical products. If this product is difficult to produce, requires fine and fine materials, and many people ask for it, its price will be high; if it is easy to prepare and oversupply, the price will be low.
However, there is no regular price in the market, or due to the special route of origin, or due to the poor quality, the price changes unpredictably. Or the number of gold per gram, or tens of gold, or even a larger or smaller number, are possible. To know the true price, when visiting chemical material stores, or observing market information, you can get a more accurate price range.

N-Acetamido-5-bromopyridine is also an organic compound. Its storage conditions are quite important, which is related to the stability and quality of this substance.
Store this substance in a dry environment. If it is in a humid place, water vapor is easy to interact with it, or cause reactions such as hydrolysis, which damage its chemical structure and reduce its purity and utility. Therefore, it should be placed in a dry and well-ventilated place to prevent moisture erosion.
Secondly, the temperature should also be paid attention to. High temperature can accelerate the rate of chemical reactions, or cause decomposition and deterioration. It should be stored in a cool place. Generally speaking, the temperature should be maintained between 15 and 25 degrees Celsius. Such a temperature range can slow down the rate of physical and chemical changes and ensure the stability of its properties.
Furthermore, light also affects it. Strong light irradiation or photochemical reaction can change the structure. Therefore, when stored in a dark place, it can be contained in a dark container such as a brown bottle to protect its chemical properties from direct light.
In addition, the storage place should be away from fire sources, oxidants, etc. Because of its flammability, it is easy to cause danger when exposed to open flames and hot topics; and the oxidant comes into contact with it, or reacts violently, endangering safety.
In summary, N-acetamido-5-bromopyridine should be stored in a dry, cool, dark place, and away from sources of ignition and oxidants, so as to ensure its quality and safety for subsequent use.