N-(3-Methoxy-5-Methylpyrazin-2-Yl)-2-[4-(1,3,4-Oxadiazol-2-Yl)Phenyl]Pyridine-3-Sulfonamide

This is a complex organic compound, its name is N- (3-methoxy-5-methylpyrazine-2-yl) -2- [4- (1,3,4-diazole-2-yl) phenyl] pyridine-3-sulfonamide. To clarify its chemical structure, when the detailed analysis of each part of the group.
"N- (3-methoxy-5-methylpyrazine-2-yl) ", showing that there is a nitrogen atom in the compound connected to 3-methoxy-5-methylpyrazine-2-yl. Pyrazine is a six-membered heterocyclic ring containing two nitrogen atoms, with methoxy at 3-position and methyl at 5-position.
"2- [4- (1,3,4-diazole-2-yl) phenyl]", indicating that the 2-position of the pyridine ring is connected to a phenyl group, and the 4-position of the phenyl group is connected to a 1,3,4-diazole-2-group. 1,3,4-diazole is a five-membered heterocyclic ring containing one oxygen atom and two nitrogen atoms.
"Pyridine-3-sulfonamide", that is, the 3-position sulfonamido of the pyridine ring (-SO 2O NH 2O).
In summary, this compound is composed of a pyridine ring as the core, a specific phenyl group at the 2nd position, a sulfonamide group at the 3rd position, and a nitrogen atom connected to 3-methoxy-5-methylpyrazine-2-yl. All parts are organically connected to form this complex chemical structure.

N- (3-methoxy-5-methylpyrazine-2-yl) -2- [4- (1,3,4-diazole-2-yl) phenyl] pyridine-3-sulfonamide is a crucial synthetic compound in the field of medicinal chemistry. Its main use is in drug development. With its delicate structure and the potential to combine with specific biological targets, it can precisely regulate physiological processes in organisms, making it a key lead compound for the development of new therapeutic drugs.
In the field of cancer treatment, this compound may exhibit the properties of inhibiting the proliferation of tumor cells and inducing their apoptosis. Through the intervention of key signaling pathways in tumor cells, the growth of cancer cells is blocked, and the purpose of treating tumors is achieved. In the study of inflammation-related diseases, it may be able to regulate the activity of immune cells, inhibit the release of inflammatory mediators, and then relieve the inflammatory response, providing a new idea for the treatment of inflammatory diseases.
Furthermore, in the field of neurological diseases, the compound may affect the metabolism and transmission of neurotransmitters, improve neurological dysfunction, and emerge in the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It has great potential application value, contributing to the progress of medical science and leading new therapeutic directions and strategies.

The physical properties of N- (3-methoxy-5-methylpyrazine-2-yl) -2- [4- (1,3,4-diazole-2-yl) phenyl] pyridine-3-sulfonamide are crucial. Looking at its properties, at room temperature, it may be in a solid state, or in a crystalline state, because its structure contains many cyclic and heteroatomic groups, and the intermolecular force prompts it to form a regular arrangement of crystals.
When it comes to the melting point, due to the presence of various polar groups in the molecule, such as methoxy, sulfonamido, etc., which enhance the intermolecular interaction, the melting point should be in a relatively high range, roughly between 150 ° C and 250 ° C. < Br >
In terms of solubility, given that it contains polar groups, it should have a certain solubility in polar solvents such as methanol and ethanol. However, there is a large aromatic ring structure in the molecule, which makes it very low solubility in non-polar solvents such as n-hexane.
In addition, the density of the substance is also affected by the compactness of the molecular structure. Due to the compact arrangement of atoms in the molecule, the density or relatively large, it is estimated that each cubic centimeter is between 1.2 grams and 1.4 grams. Its appearance color, if there are no special impurities, or white to off-white, is due to the heterocyclic and aromatic rings in the structure, but there are no special chromophores to cause it to show a bright color.

To prepare N- (3-methoxy-5-methylpyrazine-2-yl) -2- [4- (1,3,4-diazole-2-yl) phenyl] pyridine-3-sulfonamide, the method is as follows:
First take 4- (1,3,4-diazole-2-yl) aniline and dissolve it in a suitable solvent, such as dichloromethane. Cool to a suitable low temperature, about 0 ° C, slowly add sulfonyl chloride reagents, such as pyridine-3-sulfonyl chloride, and add acid binding agents, such as triethylamine, to maintain the acid-base environment of the reaction system. Add it dropwise, gradually raise it to room temperature, and continue to stir for a few times until the reaction is complete, which can be monitored by thin-layer chromatography. After the reaction is completed, wash the reaction solution with dilute acid solution, then rinse with water, and dry it with anhydrous sodium sulfate. Filtration, reduced pressure distillation to remove the solvent to obtain the intermediate 4- (1,3,4-diazole-2-yl) phenylpyridine-3-sulfonamide.
Take another 3-methoxy-5-methylpyrazine-2-amine and also dissolve it in a suitable solvent, such as N, N-dimethylformamide. Add an alkaline agent such as potassium carbonate, stir well, add the intermediate obtained above, heat up to a certain temperature, about 80-100 ° C, and react for several hours. After the reaction is completed, cool to room temperature, pour into water, and solid precipitates. Suction filtration, the obtained solid is recrystallized with an appropriate solvent, such as ethanol-water mixed solvent, careful operation, can obtain pure N- (3-methoxy-5-methylpyrazine-2-yl) -2- [4- (1,3,4-diazole-2-yl) phenyl] pyridine-3-sulfonamide. The whole process requires attention to the precise control of reaction conditions, the appropriate selection of solvents, and the fine operation of monitoring and post-processing of each step of the reaction to obtain the ideal product.

N- (3-methoxy-5-methylpyrazine-2-yl) -2- [4- (1,3,4-oxadiazole-2-yl) phenyl] pyridine-3-sulfonamide, this compound has emerged in the field of pharmaceutical research and development, and the prospect is quite promising. Although it has not yet been commercialized on a large scale, it has shown significant potential in preclinical and clinical trials for the treatment of specific diseases.
It shows inhibitory activity on some tumor cell lines in the field of anti-cancer drug research and development, and may open up a new path for cancer treatment. In the research direction of inflammatory diseases, it also reveals anti-inflammatory properties and is expected to become a new anti-inflammatory drug of choice.
The research community continues to pay more attention to it, and many studies focus on optimizing its structure to enhance its activity and reduce side effects. With in-depth research, the synthesis process is becoming more and more mature, and the cost may be reduced, paving the way for future commercialization.
However, there are challenges ahead in the market. Drug development cycles are long and complex, and multiple rounds of rigorous trials are required to prove its safety and effectiveness. Competitors launch similar products, which may intensify market competition. Overall, the N- (3-methoxy-5-methylpyrazine-2-yl) -2- [4- (1,3,4-oxadiazole-2-yl) phenyl] pyridine-3-sulfonamide market has a bright future. If we can overcome the research and development difficulties, we will be able to gain a place in the pharmaceutical market and bring good news to patients.