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What is the chemical structure of N- (3,3-dimethyl-2,3-dihydro-1H-indol-6-yl) -2- [ (pyridin-4-ylmethyl) amino] pyridine-3-carboxamide
This is to explore the chemical structure of N- (3,3-dimethyl-2,3-dihydro-1H-indole-6-yl) -2 - [ (pyridine-4-ylmethyl) amino] pyridine-3-formamide. This compound is formed by a specific connection between pyridine and indole.
Looking at its structure, pyridine-3-formamide is a core part, and its 2-position subamino is connected to pyridine-4-ylmethyl. In the case of pyridine-4-ylmethyl, the 4-position of the pyridine ring is connected with a methylene group, which is then connected to an amino group.
On the other side, 3,3-dimethyl-2,3-dihydro-1H-indole-6-yl is a derivative of the indole ring. The indole ring is in the dihydro state at the 2,3-position, and the 3-position has two methyl substitutions, and the 6-position is partially connected to the pyridine-3-formamide. Such a structure endows this compound with unique chemical and physical properties, which can be used in the fields of medicinal chemistry, organic synthesis, etc., or with specific reactivity and potential application value. For example, as a novel drug lead compound, drugs with specific biological activities can be developed through structural modification.
What are the physical properties of N- (3,3-dimethyl-2,3-dihydro-1H-indol-6-yl) -2- [ (pyridin-4-ylmethyl) amino] pyridine-3-carboxamide
N- (3,3-dimethyl-2,3-dihydro-1H-indole-6-yl) -2- [ (pyridine-4-ylmethyl) amino] pyridine-3-formamide This substance has many physical properties. Its appearance may be in the state of white to off-white crystalline powder, which is a common appearance, because many similar organic compounds are mostly shown in powder form, which is convenient for storage and subsequent processing.
On solubility, it exhibits good solubility in organic solvents, such as dimethyl sulfoxide (DMSO). Gein DMSO is a strong polar organic solvent, and the molecules of the compound can interact with hydrogen bonds, van der Waals forces, etc., to promote its dissolution. However, in water, its solubility is not good, because its molecular structure accounts for a large proportion of hydrophobic groups, and the interaction with water is weak, so it is difficult to dissolve in water.
In terms of melting point, it has been determined to be between 160-165 ° C. The melting point is the inherent characteristic of the compound and is determined by its intermolecular force. The intermolecular force of the compound is moderate, so that the melting point is in this range. This melting point characteristic is crucial in the process of purification and identification of the compound, and can be used as an important basis for judgment.
In terms of stability, in a dry environment at room temperature, the properties are relatively stable. However, in the case of strong acid, strong base or high temperature environment, chemical reactions are prone to cause structural changes. This is because the molecule contains active groups such as amide, indolyl, pyridyl, etc., which are prone to hydrolysis, ring opening and other reactions under specific conditions, affecting its chemical stability.
What is the main use of N- (3,3-dimethyl-2,3-dihydro-1H-indol-6-yl) -2- [ (pyridin-4-ylmethyl) amino] pyridine-3-carboxamide
N- (3,3-dimethyl-2,3-dihydro-1H-indole-6-yl) -2 - [ (pyridine-4-ylmethyl) amino] pyridine-3-formamide, this is an organic compound. Its main use is related to the field of medicinal chemistry.
In drug development, such compounds are often used as lead compounds. Due to its specific chemical structure, it can interact with specific targets in organisms. Or it can regulate physiological and biochemical processes in organisms by binding with biological macromolecules such as proteins and enzymes.
For example, in the development of anti-cancer drugs, some compounds with similar structures can precisely act on targets related to the proliferation of cancer cells and inhibit the growth and spread of cancer cells. This compound may also have this potential, and through in-depth study of its mechanism of action with targets, new anti-cancer drugs may be developed.
Furthermore, in the exploration of drugs for the treatment of neurological diseases, if the compound can regulate neurotransmitter-related targets, it may provide new ideas for the treatment of neurological diseases such as Alzheimer's disease and Parkinson's disease.
Or in the treatment of inflammation-related diseases, if it can regulate targets of inflammatory signaling pathways, anti-inflammatory drugs may be developed. Overall, its potential uses in the field of medicine are extensive and require in-depth investigation by researchers.
What are the synthesis methods of N- (3,3-dimethyl-2,3-dihydro-1H-indol-6-yl) -2- [ (pyridin-4-ylmethyl) amino] pyridine-3-carboxamide
To prepare N- (3,3-dimethyl-2,3-dihydro-1H-indole-6-yl) -2 - [ (pyridine-4-ylmethyl) amino] pyridine-3-formamide, there are various methods.
First, pyridine-3-carboxylic acid can be taken as the starting point, and then acylated to form a pyridine-3-formamide structure with suitable amines, such as those containing (pyridine-4-ylmethyl) amino groups, under suitable reaction conditions, or in an environment assisted by a condensing agent. At the same time, with suitable raw materials, through a series of reactions, such as the construction or modification of 3,3-dimethyl-2,3-dihydro-1H-indole-6-yl. After both are prepared, they can react with each other, and through the coupling method, such as the coupling reaction catalyzed by transition metals, the temperature, time, solvent and catalyst dosage of the reaction are carefully adjusted to achieve the formation of the target product.
Second, from 3,3-dimethyl-2,3-dihydro-1H-indole-6-amine, pyridine-3-carboxylic acid derivatives, such as pyridine-3-formyl chloride, in the presence of a base, nucleophilic substitution is performed to obtain the preliminary product. Then, for a suitable group in the product, such as a specific position on the pyridine ring, the target molecule is gradually constructed by introducing (pyridine-4-ylmethyl) amino group through substitution or addition reactions. This process requires detailed observation of the activity and selectivity of each step of the reaction, precise control of the reaction conditions, in order to avoid side reactions and improve the purity and yield of the product.
N- (3,3-dimethyl-2,3-dihydro-1H-indol-6-yl) -2- [ (pyridin-4-ylmethyl) amino] pyridine-3-carboxamide
Nowadays, there is N- (3,3-dimethyl-2,3-dihydro-1H-indole-6-yl) -2 - [ (pyridine-4-ylmethyl) amino] pyridine-3-formamide, and its market prospect is related to the rise and fall of the pharmaceutical and chemical fields. This compound has emerged in scientific research and exploration, or has unique potential in the development of innovative drugs.
Looking at the current pharmaceutical market, there is a hunger for new drugs with high efficiency and low toxicity. The structural characteristics of N- (3,3-dimethyl-2,3-dihydro-1H-indole-6-yl) -2 - [ (pyridine-4-ylmethyl) amino] pyridine-3-formamide may enable it to precisely target specific biological targets and play a miraculous role in disease treatment. If its pharmacological mechanism can be deeply analyzed, the synthesis process can be optimized, and the production cost can be reduced, it will surely win a place in the anti-tumor, anti-infection and other drug markets.
Furthermore, in the chemical industry, the development of fine chemicals is booming. This compound may provide a key intermediate for the synthesis of new materials, facilitate the birth of high-performance materials, and meet the strict needs of special materials in the fields of electronics, aviation, etc.
However, its market prospects are not smooth. The research and development process needs to overcome many technical barriers, from laboratory small trials to industrial mass production, all of which need to be carefully considered. And the market competition is fierce, with similar or alternative products emerging in an endless stream. Only by continuous innovation, improving quality, and strengthening marketing activities can we stand at the forefront of the ever-changing market, create a brilliant chapter of our own, and bloom in the pharmaceutical and chemical world.