methyl ester of 3-aminopyridine-4-carboxylic acid

3-Aminopyridine-4-carboxylpyridine methyl ester is mainly used in pharmaceuticals, materials science, organic synthesis and other fields.
In the pharmaceutical process, it is a key intermediate. It can undergo many chemical reactions to build complex compounds that are biologically active or can become drugs for the treatment of specific diseases. For example, in the development of some anti-cancer drugs, 3-aminopyridine-4-carboxylpyridine methyl ester can participate in the key step of modifying and derivatizing to obtain molecules that target cancer cells to precisely inhibit the growth and spread of cancer cells. < Br >
In the field of materials science, due to molecular structural properties, it can be used as a basic element for building functional materials. For example, by preparing optoelectronic materials, using their conjugated structure and electronic properties, the materials can obtain good photoelectric conversion properties, or used in organic Light Emitting Diodes (OLEDs), solar cells, etc., to improve their efficiency and stability.
In the field of organic synthesis, it is an extremely useful building block. With the activity of amino groups and carboxyl methyl esters, it participates in many classic organic reactions, such as amidation reactions, esterification reactions, etc., to build a complex organic molecular skeleton. Through rational design of reaction routes, organic compounds with diverse structures and functions can be synthesized, providing assistance for the development of organic synthesis chemistry. In conclusion, 3-aminopyridine-4-carboxypyridyl methyl ester is of great significance in modern chemistry and related fields. It has a wide range of uses, opening up many possibilities for new drug creation and material innovation, and promoting the continuous progress of science and technology.

There are various ways to synthesize 3-hydroxybutyric acid-4-cyanoethyl ester.
First, 3-hydroxybutyric acid is used as the starting material. First, 3-hydroxybutyric acid is interacted with thionyl chloride, and the hydroxyl group is replaced by a chlorine atom to obtain 3-chlorobutyric acid. This step requires attention to the control of reaction temperature and time to prevent side reactions from breeding. Then, 3-chlorobutyric acid reacts with sodium cyanide in a suitable solvent, and the chlorine atom is replaced by a cyanyl group to generate 3-cyanobutyric acid. Finally, 3-cyanobutyric acid and ethanol are esterified under the catalysis of concentrated sulfuric acid, resulting in 3-hydroxybutyric acid-4-cyanoethyl ester. This route step is clear, but some reaction conditions are more severe, and sodium cyanide is highly toxic, so the operation must be cautious.
Second, acetaldehyde can be started from acetaldehyde. Acetaldehyde is condensed by hydroxyaldehyde to obtain 3-hydroxybutyraldehyde. This reaction requires a base as a catalyst, such as sodium hydroxide solution. During the reaction, the reaction process and the ratio of product should be closely watched. 3-hydroxybutyric acid can be obtained by further oxidation of 3-hydroxybutyraldehyde. The oxidation process requires the selection of appropriate oxidizing agents, such as Jones reagent. The next step is the same as the method using 3-hydroxybutyric acid as the raw material, and the target product is obtained by substitution, cyanidation, and esterification. This route of raw materials is common, but the condensation and oxidation steps of hydroxyaldehyde need to be carefully regulated to ensure yield and purity.
Third, ethyl acrylate is used as the raw material. Ethyl acrylate first reacts with hydrocyanic acid to form 2-cyano-3-hydroxypropionate ethyl ester. This addition reaction requires specific catalysts, such as certain metal complexes. Subsequently, 2-cyano-3-hydroxypropionate ethyl ester is converted into 3-hydroxybutyric acid-4-cyanoethyl ester through intramolecular rearrangement and further reaction. This route is relatively novel, but it involves special catalysts and rearrangement reactions, which require quite high technical requirements, and also require high reaction equipment and operation skills.

Ethyl 3-hydroxybutyrate, also known as ethyl 4-hydroxybutyrate, is a colorless to light yellow liquid with a weak special odor. Its physical and chemical properties are as follows:
- ** Physical properties **:
- ** Appearance **: It is a colorless to light yellow transparent liquid at room temperature and pressure, and it is clear and translucent without visible impurities to the naked eye. This appearance characteristic is convenient for observing and judging its state in practical applications.
- ** Odor **: emits a weak special odor, non-pungent or strong odor. This odor characteristic can be used as one of the preliminary identification bases in specific scenarios. < Br > - ** Boiling point **: about 180 ° C, the boiling point makes it change from liquid to gaseous at relatively high temperatures. In chemical operations such as distillation and separation, corresponding temperature conditions are required to achieve its gasification separation.
- ** Melting point **: about - 43 ° C, which indicates that at lower temperatures, ethyl 3-hydroxybutyrate can still maintain a liquid state, exhibiting good low temperature fluidity, which is of great significance for applications related to low temperature environments.
- ** Solubility **: It can be miscible with organic solvents such as ethanol and ether, and has a certain solubility in water. This solubility makes it possible to have a wide range of applications in different solvent systems. In the fields of organic synthesis, drug preparation, etc., the appropriate solvent combination can be selected according to the reaction requirements.
- ** Chemical properties **:
- ** Hydrolysis of esters **: As an ester compound, hydrolysis can occur under acid or base catalysis conditions. Hydrolysis under acidic conditions to generate 3-hydroxybutyric acid and ethanol; hydrolysis under alkaline conditions to generate 3-hydroxybutyrate and ethanol. This hydrolysis property can be used to prepare corresponding acids or salt compounds in organic synthesis.
- ** Hydroxy reaction **: The molecule contains hydroxyl groups, and typical hydroxyl-related reactions can occur. If esterification reaction occurs with carboxylic acid under acid catalysis, new ester compounds are formed; under the action of appropriate oxidants, hydroxyl groups can be oxidized to aldehyde groups or carboxyl groups, which provides the possibility for the synthesis of more complex organic compounds.
- ** Stability **: Under normal temperature and pressure and general storage conditions, ethyl 3-hydroxybutyrate has good chemical stability and is not prone to spontaneous chemical reactions. However, it is necessary to avoid long-term contact with strong oxidants, strong acids, strong bases and other substances to prevent violent reactions from affecting their quality and performance.

The market prospect of 3-aminopyridine-4-carboxylbenzyl ester is related to many parties. Looking at it, this substance has great potential in the field of pharmaceutical research and development. Due to the chemical activity of amino and carboxyl groups, it can become a key building block for the construction of new drug molecules. For doctors to cure diseases and save people, new drugs are needed to treat various diseases. The pharmacy is constantly looking for new compounds, hoping that they have unique pharmacological activities and low toxicity and side effects. 3-aminopyridine-4-carboxylbenzyl ester may be chemically modified to fit specific drug targets, and it has emerged in the field of anti-tumor and anti-infection drug research. Its market is also expected to expand because of this.
Furthermore, in the field of materials science, it also has something to draw from. With the advance of science and technology, the need for special functional materials is increasing. The structural properties of this compound may endow the material with unique optical, electrical or mechanical properties. For example, in optoelectronic devices, its photoelectric conversion efficiency may be optimized; for polymer materials, its mechanical properties may be improved. The vigorous development of the material field has created a strong demand for novel structural compounds, which brings business opportunities for 3-aminopyridine-4-carboxylbenzyl ester.
However, its market prospects are not without challenges. The complexity and cost of the synthesis process are difficult problems to face. If the synthesis steps are complicated and the yield is low, the cost will be high and the market competitiveness will be weakened. Furthermore, regulations and policies are stricter on the supervision of chemicals, and their safety and environmental impact need to be evaluated in detail. Only products that are compliant and safe can enter the market.
In summary, the market of 3-aminopyridine-4-carboxylbenzyl ester has bright prospects and challenges. If the synthesis process is optimized, the cost is controlled properly, and the regulatory requirements can be complied with, it must occupy a place in the pharmaceutical and materials markets and bloom.

When storing and transporting 3-hydroxybutyric acid-4-butyrolactone, there are a number of matters that need to be paid attention to and handled with caution.
First, this material has a certain chemical activity and requires a high storage environment. It should be placed in a cool, dry and well-ventilated place, away from fire, heat and oxidants. Because if it comes into contact with oxidants, it is easy to cause violent chemical reactions, or even risk fire and explosion. And because it is sensitive to temperature, high temperature, or its properties change, affecting quality and safety.
Second, the choice of storage containers is also crucial. When using corrosion-resistant, well-sealed containers to prevent their leakage. Common such as special plastic containers or glass containers, it depends on the specific situation. If the container is not selected properly, it may react with the container material, cause product deterioration, and it is difficult to deal with after leakage, or pose a threat to the environment and personal safety.
Third, during transportation, relevant regulations and standards must be strictly followed. Equipped with professional escorts, transportation vehicles must also meet safety requirements, and have corresponding protection and emergency facilities. If bumps, collisions and other conditions are encountered on the way, the container may be damaged and leaked, so measures such as shock absorption and fixing should be taken.
Fourth, whether it is storage or transportation, clear signs should be set up, indicating its name, danger and other information. In the event of an accident, others can quickly learn about the situation and take appropriate measures to avoid delaying the treatment due to unclear nature and exacerbating the harmful consequences.