Methyl 6 Hydroxymethyl Pyridine 3 Carboxylate
pyridine pyrrole pyrazine piperidine piperazine

methyl 6-(hydroxymethyl)pyridine-3-carboxylate

    Specifications

    HS Code

    426375

    Chemical Formula C8H9NO4
    Molar Mass 183.16 g/mol
    Appearance Solid (assumed, as no data on color given)
    Boiling Point No data available
    Melting Point No data available
    Solubility In Water No data available
    Solubility In Organic Solvents No data available
    Density No data available
    Pka No data available
    Flash Point No data available

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    General Information
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    Frequently Asked Questions

    As a leading methyl 6-(hydroxymethyl)pyridine-3-carboxylate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of methyl 6- (hydroxymethyl) pyridine-3-carboxylate
    Methyl-6- (hydroxymethyl) pyridine-3-carboxylic acid ester, this is an organic compound. Its form or crystalline powder is quite stable at room temperature and pressure.
    In terms of its solubility, it can be slightly soluble in water, but more soluble in organic solvents such as ethanol and ether. The reason is that its molecular structure contains hydrophilic hydroxymethyl groups and hydrophobic pyridine rings and ester groups. This special structure causes it to exhibit different solubility characteristics in different solvents.
    In terms of chemical activity, the ester group of the compound can be hydrolyzed, and under the catalysis of acids or bases, it can react with water to form corresponding carboxylic acids and alcohols. Hydroxymethyl has active hydrogen atoms and can participate in reactions such as esterification and etherification. The nitrogen atom of the pyridine ring has a lone pair of electrons, which can be used as a ligand for complexing with metal ions, and can also be used as an activity check point in nucleophilic substitution reactions.
    Because its structure contains a variety of active groups, it is widely used in the field of organic synthesis. It can be used as a key intermediate to prepare biologically active pharmaceutical molecules, pesticides, or to synthesize polymers with special properties in materials science.
    This compound has unique chemical properties and has potential application value in many fields. However, when actually used, it needs to be properly handled and stored according to its characteristics.
    What are the main uses of methyl 6- (hydroxymethyl) pyridine-3-carboxylate
    Methyl-6- (hydroxymethyl) pyridine-3-carboxylic acid ester, which has a wide range of uses. In the field of medicinal chemistry, it can be used as a key intermediate to assist in the synthesis of many compounds with special pharmacological activities. The structure of gainpyridine and carboxylic acid esters endows the molecule with unique chemical properties and can participate in a variety of chemical reactions, such as nucleophilic substitution, esterification, amidation, etc., laying the foundation for the creation of new drugs, or for the synthesis of drugs for the treatment of specific diseases, such as antibacterial, anti-inflammatory, and anti-tumor drugs.
    In the field of materials science, it also has potential uses. With its structural characteristics, it can be introduced into the main chain or side chain of polymer materials through specific chemical reactions, giving the material new properties, such as improving material solubility, thermal stability, mechanical properties, etc. It is expected to be used in the preparation of functional polymer materials, such as intelligent responsive materials, biodegradable materials, and has application prospects in packaging, tissue engineering and other fields.
    Furthermore, in the field of organic synthetic chemistry, it is an important building block for organic synthesis. Because it contains multiple active check points, it can be ingeniously designed to react with different reagents to construct complex organic molecular structures, providing organic synthetic chemists with more strategies and methods for constructing target molecules, and playing an important role in the total synthesis of complex natural products and the creation of new organic functional molecules. In conclusion, methyl-6- (hydroxymethyl) pyridine-3-carboxylic acid ester has shown important application value in many fields due to its unique structure, which brings many possibilities for scientific research and industrial production.
    What is the synthesis method of methyl 6- (hydroxymethyl) pyridine-3-carboxylate
    To prepare methyl 6- (hydroxymethyl) pyridine-3-carboxylic acid ester, you can follow the following method.
    First take 6-methylniacin, which is the key starting material. Dissolve it in a suitable solvent, such as dichloromethane or N, N-dimethylformamide. In a low temperature environment, such as 0 ° C to 5 ° C, slowly add an appropriate amount of oxidant, such as chromium trioxide-pyridine complex. This oxidant can oxidize the methyl of 6-methylniacin to aldehyde groups to generate 6-formylniacin.
    Then, dissolve 6-formylniacin in an alcohol solvent, such as methanol, and add an appropriate amount of sodium borohydride. Sodium borohydride is a mild reducing agent. Under low temperature to room temperature conditions, the aldehyde group can be reduced to hydroxymethyl to obtain 6- (hydroxymethyl) niacin.
    Then 6 - (hydroxymethyl) niacin is mixed with methanol, and an appropriate amount of concentrated sulfuric acid is added as a catalyst. Under the condition of heating and reflux, an esterification reaction is carried out. This reaction can prompt the carboxyl group of 6- (hydroxymethyl) niacin to react with the hydroxyl group of methanol to form methyl 6- (hydroxymethyl) pyridine-3-carboxylic acid ester. < Br >
    At the end of the reaction, the product can be purified by a suitable method. If vacuum distillation is used, unreacted methanol and other volatile impurities can be removed. Then, by column chromatography, a suitable eluent is selected to further purify the product to obtain a purified methyl 6- (hydroxymethyl) pyridine-3-carboxylate.
    Methyl 6- (hydroxymethyl) pyridine-3-carboxylate in storage and transportation
    Methyl 6- (hydroxymethyl) pyridine-3-carboxylate is an organic compound, and all matters need to be treated with caution during storage and transportation.
    When stored, the first environment is dry. If this compound encounters moisture or triggers reactions such as hydrolysis, it will deteriorate. Therefore, when placed in a dry place, a desiccant can be used to assist in maintaining the dry environment.
    Temperature is also critical. It should be stored in a cool environment to avoid high temperature. High temperature may cause thermal decomposition or accelerate chemical reactions, which will damage its quality. Generally speaking, room temperature or slightly lower than room temperature is appropriate.
    Furthermore, it should be noted that the storage place should be well ventilated. To prevent the accumulation of volatile gases from compounds, one is to avoid potential safety hazards, and the other is to prevent the interaction between gases and compounds, which will affect their stability.
    The transportation process should also not be ignored. The packaging must be solid and reliable to prevent the container from being damaged due to collision and vibration, and the compound from leaking. Select suitable packaging materials to have corrosion resistance to the compound.
    The transportation environment should also be maintained stable to avoid large fluctuations in temperature and humidity. If the transportation time is long, the environmental conditions should be closely monitored.
    In addition, follow relevant regulations and standards. Whether it is storage or transportation, it is necessary to comply with the regulations of chemical management to ensure the safety of personnel and the environment is not polluted. Only in this way can the methyl 6- (hydroxymethyl) pyridine-3-carboxylate be properly stored and transported to ensure its quality and safety.
    What is the market outlook for methyl 6- (hydroxymethyl) pyridine-3-carboxylate?
    Methyl 6- (hydroxymethyl) pyridine-3-carboxylic acid ester, which has potential value in the chemical and pharmaceutical fields. Looking at its market prospects, it is like the rising sun, containing vigorous vitality.
    In the chemical industry, this compound is often used as a key intermediate for the preparation of a wide variety of fine chemicals. With the steady progress of the chemical industry, the demand for fine chemicals is also rising. The manufacturing industry continues to pursue high-quality, high-performance materials, and the demand for methyl 6- (hydroxymethyl) pyridine-3-carboxylic acid ester is expected to increase steadily as an important raw material.
    As for the pharmaceutical field, it may have unique biological activities, which can become a key cornerstone in the journey of new drug research and development. With the rapid development of pharmaceutical science and technology, the demand for new drugs is always strong. Researchers have been unremitting in exploring new chemical entities, methyl 6 - (hydroxymethyl) pyridine - 3 - carboxylic acid esters or their structural characteristics, finding a broad application in the field of pharmaceutical chemistry.
    However, although the market prospect is broad, there are also challenges. The complexity of the synthesis process or the high production cost will affect the market competitiveness. And the market competition is fierce. Many enterprises and scientific research institutions are involved in related research and production. To stand out, they need to work hard on technological innovation and cost control.
    But overall, methyl 6 - (hydroxymethyl) pyridine - 3 - carboxylic acid ester due to the key role in the chemical and pharmaceutical fields, coupled with the general trend of industry development, its market prospects are quite bright, over time, through reasonable development and application, will bloom bright light, injecting strong impetus into the development of related industries.