Methyl 6 Hydroxymethyl Pyridine 2 Carboxylate
pyridine pyrrole pyrazine piperidine piperazine

methyl 6-(hydroxymethyl)pyridine-2-carboxylate

    Specifications

    HS Code

    902791

    Chemical Formula C8H9NO4
    Molar Mass 183.162 g/mol
    Appearance Solid (predicted)
    Boiling Point Predicted to be around 318.6 °C at 760 mmHg
    Solubility In Water Limited solubility, organic solvents may be more effective
    Density Estimated around 1.29 g/cm³
    Flash Point Predicted around 146.5 °C
    Pka Values for pyridine - carboxylic acid and hydroxymethyl groups can influence acidity
    Stability Stable under normal conditions, but may react with strong oxidizing or reducing agents

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    General Information
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    Frequently Asked Questions

    As a leading methyl 6-(hydroxymethyl)pyridine-2-carboxylate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of methyl 6- (hydroxymethyl) pyridine-2-carboxylate
    Methyl 6 - (hydroxymethyl) pyridine-2 -carboxylic acid ester is an organic compound. It has specific chemical properties, and I am here for you.
    This compound contains pyridine rings, which are aromatic and stable in nature, and can participate in a variety of aromatic electrophilic substitution reactions. The hydroxymethyl group at the 6 position on the ring has a certain hydrophilicity due to the presence of hydroxyl groups. Hydroxyl groups are active and can undergo many reactions, such as esterification with acids to form corresponding esters. Hydroxyl hydrogens are replaced in this process. And under appropriate oxidation conditions, hydroxymethyl groups can be oxidized to aldehyde groups and even carboxyl groups.
    Furthermore, the carboxylic acid ester group of the 2 position has a certain polarity due to the existence of carbonyl groups. It can undergo hydrolysis under basic or acidic conditions. When alkaline hydrolysis, carboxylic salts and alcohols are formed; when acidic hydrolysis, carboxylic acids and alcohols are formed. In addition, the compound contains multiple functional groups, and the functional groups interact with each other, or change its reactivity and selectivity.
    In short, the chemical properties of methyl 6 - (hydroxymethyl) pyridine - 2 - carboxylic acid esters are rich, which are caused by the synergistic action of functional groups in its structure. It may have important uses in organic synthesis and other fields.
    What are the synthesis methods of methyl 6- (hydroxymethyl) pyridine-2-carboxylate
    The methods for synthesizing methyl 6- (hydroxymethyl) pyridine - 2 - carboxylate (6-hydroxymethyl pyridine - 2 - methyl formate) are as follows.
    First, pyridine - 2 - methyl formate is used as the starting material. Shilling pyridine - 2 - methyl formate reacts with formaldehyde under the catalysis of bases. Bases such as potassium carbonate, sodium carbonate, etc., are heated and stirred in suitable solvents such as methanol, ethanol or dichloromethane. In this process, formaldehyde provides hydroxymethyl, and the base helps the reaction to produce 6 - hydroxymethylpyridine - 2 - methyl formate. After the reaction is completed, the pure product can be obtained through extraction, washing, drying and distillation.
    Second, start with methyl 6-methylpyridine-2-formate. Under specific reaction conditions, the methyl of 6-methylpyridine-2-formate is oxidized to hydroxymethyl by selective oxidation with mild oxidants, such as manganese dioxide and reactive oxygen species. The key to this reaction is to control the degree of oxidation and avoid excessive oxidation. After the reaction, the target product can be obtained after separation and purification.
    Third, the target structure is constructed through a multi-step reaction with a suitable pyridine derivative as the starting material. The carboxyl methyl ester group is first introduced through a substitution reaction, and then the hydroxymethyl group is introduced at a suitable position. This path requires careful design of the reaction sequence and conditions to ensure the selectivity and yield of each step of the reaction. After each step of the reaction, careful separation and purification are required to ensure the purity of the final product.
    The above methods have advantages and disadvantages. In actual synthesis, careful choices should be made according to factors such as raw material availability, cost, reaction conditions and product purity requirements.
    What is the main use of methyl 6- (hydroxymethyl) pyridine-2-carboxylate?
    Methyl 6- (hydroxymethyl) pyridine-2-carboxylic acid esters have a wide range of uses. In the field of pharmaceutical and chemical industry, it is often used as a key intermediate. This is because of its unique activity, it can be derived from a variety of chemical reactions, and can be used to create new drugs to treat various diseases.
    In the process of organic synthesis, it is also an important building block. Due to its special structure of pyridine ring, ester group and hydroxymethyl group, it can participate in many complex organic reactions, assisting chemists in constructing various novel and specific organic molecules. It can be used in the preparation of functional materials in the field of materials science, such as the preparation of materials with recognition functions for specific substances, or materials with special optical and electrical properties.
    Furthermore, in chemical research, as a model compound, it helps researchers to deeply explore the reaction mechanism and molecular interactions. Because of the interaction of different functional groups in its structure, it can provide rich examples for chemical theoretical research, to understand the change law of molecules under various reaction conditions, and to contribute to the development of organic chemistry. In short, methyl 6- (hydroxymethyl) pyridine-2-carboxylate plays an indispensable role in many fields, promoting the progress and development of related science and technology.
    Methyl 6- (hydroxymethyl) pyridine-2-carboxylate what to pay attention to when storing and transporting
    Methyl 6- (hydroxymethyl) pyridine-2-carboxylate is a chemical substance. When storing and transporting, many key things need to be paid attention to.
    When storing, the first priority is to choose the environment. You should find a cool, dry and well-ventilated place, because the substance may be afraid of high temperature and humidity. High temperature can easily cause its chemical properties to change, and humidity may cause its hydrolysis and other reactions, which will damage its quality. In addition, you need to keep away from fires and heat sources. Because it may be flammable, it may be dangerous to encounter open flames and hot topics.
    Packaging is also essential. It must be properly stored in a sealed package to prevent contact with air and avoid reactions such as oxidation. And the packaging material must be able to resist the corrosion of the substance to ensure safe storage.
    When transporting, follow relevant regulations and standards. Handling must be light and light, beware of packaging damage. If the packaging is damaged and the substance leaks, it will not only pollute the environment, but also endanger the safety of transporters. Transportation vehicles also need to be equipped with corresponding fire equipment and leakage emergency treatment equipment to deal with emergencies. At the same time, during transportation, sun exposure and rain should be avoided, and appropriate temperature and humidity should be maintained to ensure that methyl 6- (hydroxymethyl) pyridine-2-carboxylate is stable and does not change unexpectedly during transportation.
    What is the market outlook for methyl 6- (hydroxymethyl) pyridine-2-carboxylate?
    Guanfu methyl 6- (hydroxymethyl) pyridine -2 -carboxylate is an interesting topic in today's market prospects. This compound is a key intermediate in the field of organic synthesis, and its use is quite extensive, involving various industries such as medicine, pesticides, and materials science.
    In the pharmaceutical industry, it can be used as the cornerstone for the synthesis of many specific drugs, helping to develop innovative therapies for specific diseases. With the increasing global emphasis on health and the continuous improvement of pharmaceutical research and development, the demand for such intermediates is bound to rise. Looking at the current booming pharmaceutical market, new drug research and development is emerging in an endless stream. This compound has a bright future because it can introduce unique structures into drug molecules, endowing drugs with better activity and selectivity.
    As for the field of pesticides, with the increasing attention to food safety and environmental protection, the research and development of high-efficiency and low-toxicity pesticides has become the general trend. Methyl 6- (hydroxymethyl) pyridine -2 -carboxylate may be able to contribute to the creation of new pesticides by virtue of its structural characteristics and meet the market demand for green and environmentally friendly pesticides. Its market potential cannot be underestimated.
    Furthermore, in the field of materials science, with the rapid development of science and technology, the demand for new materials is also continuous. This compound may participate in the synthesis of materials with special properties, such as optical materials, electronic materials, etc. The current rapid development of materials science, constantly exploring new fields, as a potential material synthesis raw materials, is expected to emerge in the emerging materials market.
    However, its market prospects are not without challenges. The optimization of the synthesis process and the control of production costs are all issues that need to be solved urgently. Only by overcoming such problems can we stand out in the market competition and enjoy the dividends brought by the broad prospects. In summary, although methyl 6- (hydroxymethyl) pyridine -2 -carboxylate faces some challenges, its wide application potential in many industries indicates that it will occupy a place and bloom in the future market.