Methyl 6-chloro-5-hydroxypyridine-3-carboxylate

Methyl-6-chloro-5-hydroxypyridine-3-carboxylic acid ester is one of the organic compounds. It has unique chemical properties. In terms of physical properties, it is usually solid, but it also varies according to specific conditions. In terms of solubility, it has a certain solubility in organic solvents such as ethanol and acetone. Due to the molecular structure of the compound, there are both lipophilic methyl groups and chlorine atoms, and hydrophilic hydroxyl groups and carboxyl ester groups, so it is soluble in organic solvents.
Its chemical activity is quite considerable. Hydroxyl groups can participate in many chemical reactions, such as esterification reactions, and can interact with acids to form corresponding ester compounds. This process requires appropriate catalysts and reaction conditions. Carboxyl ester groups are also active, and under basic conditions, hydrolysis can occur to generate corresponding carboxylic salts and alcohols. Chlorine atoms can participate in nucleophilic substitution reactions. When suitable nucleophilic reagents are present, chlorine atoms can be replaced to form new compound structures.
In addition, the pyridine ring of the compound gives it a certain alkalinity, which can react with acids to form salts. Due to its unique chemical properties, it has potential application value in the fields of drug synthesis, materials science, etc., and can be used as an important intermediate for the preparation of more complex compounds with specific functions.

Methyl-6-chloro-5-hydroxypyridine-3-carboxylic acid ester is one of the organic compounds and has important uses in many fields.
First, it can be a key intermediate in the synthesis of medicine. Taking the creation of antibacterial drugs as an example, the structural properties of this compound can help chemists build a molecular structure with specific antibacterial activities. Through the ingenious modification and transformation of its hydroxyl groups, chlorine atoms and ester groups, new drugs that have high inhibitory effects on specific bacteria can be synthesized, adding a weapon for human beings to fight diseases.
Second, it has also attracted much attention in the development of pesticides. Due to its structure, it can derive substances with high selective toxicity to pests. For example, for some pests that suck plant sap, the pesticide prepared by methyl-6-chloro-5-hydroxypyridine-3-carboxylate as the starting material through a series of reactions can precisely act on the specific physiological process of pests, interfering with their growth and reproduction, thus effectively protecting crops and improving grain yield and quality.
Furthermore, in the field of materials science, it may be involved in the preparation of functional materials. Its unique chemical structure may endow the material with special optical and electrical properties. For example, in the synthesis of some organic photovoltaic materials, the introduction of this compound structure unit is expected to improve the charge transport performance of the material, thereby improving the performance of related photovoltaic devices, such as organic Light Emitting Diodes, solar cells, etc.

To prepare methyl 6-chloro-5-hydroxypyridine-3-carboxylate, the method is as follows:
First, take a suitable pyridine compound as the starting material. This raw material must have a pyridine ring structure and reserve a modifiable group at a specific position for subsequent introduction of the desired substituent.
Chemically introduce a chlorine atom at the 6th position of the pyridine ring. A suitable chlorination reagent, such as a chlorine-containing halogen, can be used to replace the hydrogen atom at the 6th position of the pyridine ring under suitable reaction conditions. The reaction conditions include suitable solvents, such as non-protic organic solvents, and appropriate temperature and reaction time to ensure that the reaction proceeds in the desired direction.
Introduce hydroxyl groups at the 5th position of the pyridine ring. It can be achieved by a specific nucleophilic substitution reaction or oxidation reaction. If nucleophilic substitution is used, a suitable nucleophilic reagent needs to be selected. This reagent contains hydroxyl groups or groups that can be converted into hydroxyl groups. Under certain conditions, it reacts with the pyridine ring to introduce the hydroxyl group into the 5th position. If oxidation is used, a suitable oxidizing agent needs to be selected to precisely control the reaction, so that the 5th position is oxidized to generate hydroxyl groups.
Construct carboxyl groups at the 3rd position of the pyridine ring and convert them to methyl esters Carboxyl precursors, such as cyanyl groups, can be introduced at the 3 position through nucleophilic addition-elimination reactions, and converted into carboxyl groups by hydrolysis. Subsequently, methanol and carboxyl groups are esterified in the presence of catalysts to generate methyl 6-chloro-5-hydroxypyridine-3-carboxylate. In this process, the choice of catalyst and the regulation of reaction conditions are extremely critical, such as temperature, reaction time and proportion of reactants, which will affect the yield and purity of the product.
After each step of the reaction, suitable separation and purification methods, such as extraction, column chromatography, etc., are required to obtain a purified target product and ensure that its quality and purity meet the requirements. Thus, methyl 6-chloro-5-hydroxypyridine-3-carboxylate can be prepared.

The price range of methyl 6-chloro-5-hydroxypyridine-3-carboxylic acid ester is difficult to determine when it is on the market. This is due to many reasons, which makes its price change.
First, the price of raw materials is related to the price of this product. If the price of the materials used in the synthesis of methyl 6-chloro-5-hydroxypyridine-3-carboxylic acid ester rises and falls, the price of this product will also change. If the basic compound, chlorine source, hydroxylating agent, etc., if the supply and demand change, the price will be different. Raw materials are rare and expensive, and if they are sufficient, they will be cheap, all of which affect the price of the finished product.
Second, the method and scale of preparation are also the main factors. The subtle and efficient method can reduce the production cost; the large-scale production, the cost per unit may be reduced, and the price will also be lower. However, if the law is clumsy and the regulations are small, the cost will be high, and the price will be the highest.
Third, the supply and demand of the city determine the price. If there are many applicants and few suppliers, the price will rise; if there is more production and less demand, the price will decline. This product is used in medicine, agrochemical and other industries. If the demand of these industries changes, the price will also be different.
Fourth, regulations and policies also have an impact. If environmental regulations are strict, the cost of production will increase, and the price may increase; conversely, if the regulations are loose and production is encouraged, the price may decrease.
In summary, the market price of methyl 6-chloro-5-hydroxypyridine-3-carboxylate, or because of the above ends, is different, and it is difficult to determine the exact price range.

Methyl 6-chloro-5-hydroxypyridine-3-carboxylic acid ester is also an organic compound. Its storage conditions are quite important, which is related to the quality and stability of this compound.
This compound should be stored in a cool, dry and well-ventilated place. In a cool environment, it can avoid chemical reactions caused by excessive temperature. Under high temperature, the molecular activity is enhanced, or adverse reactions such as decomposition and polymerization are induced, which damage its inherent properties. A dry environment is also indispensable, because moisture can easily make the compound hygroscopic or cause changes such as hydrolysis. Water molecules intervene or change its chemical structure, which in turn affects its use. Good ventilation can disperse volatile substances that may be generated in time to avoid potential safety hazards caused by their accumulation.
Furthermore, store this material away from fire and heat sources. Fire and heat can cause it to burn or even explode, because it is flammable or chemically active. At the same time, it should be stored separately from oxidants, acids, bases, etc. to prevent interaction. Oxidants are highly oxidizing, while acids and bases are active. When they meet methyl 6-chloro-5-hydroxypyridine-3-carboxylic acid ester, they may react violently, causing material deterioration and increasing safety risks.
And storage containers must be tightly sealed to prevent volatilization and leakage. Volatilization reduces the content and affects the use; leakage is not only waste, but also pollutes the environment. If it is toxic and harmful, it may even endanger human health and ecological balance. In short, following such storage conditions can preserve the quality and safety of methyl 6-chloro-5-hydroxypyridine-3-carboxylate.