METHYL 6-BROMO-5-FLUOROPYRIDINE-2-CARBOXYLATE

Methyl 6-bromo-5-fluoropyridine-2-carboxylate (METHYL 6-BROMO-5-FLUOROPYRIDINE-2-CARBOXYLATE) has a wide range of uses and is a key organic intermediate in the field of pharmaceutical synthesis. It can be cleverly combined with other compounds through specific chemical reactions to construct drug molecular structures with unique physiological activities. For example, in the development of antibacterial drugs, it can be used as a starting material to synthesize new antibacterial agents that have inhibitory or killing effects on specific bacteria through multi-step reactions. By precisely modifying the substituents on the pyridine ring, the affinity and mode of action between the drug and the target of the bacteria can be adjusted.
It is also of great value in the field of materials science. Due to its molecular structure containing specific functional groups, it can participate in the polymerization reaction and prepare polymer materials with unique functions. For example, synthesizing polymers with photoelectric properties can be used as light-emitting layers or charge transport layer materials in organic Light Emitting Diodes (OLEDs) or solar cells and other photovoltaic devices. By means of the electronic effects of fluorine and bromine atoms, the electrical and optical properties of the materials can be optimized, and the device efficiency and stability can be improved.
In organic synthetic chemistry, it is a commonly used building block. Chemists can use it to carry out reactions such as halogenation reactions, nucleophilic substitution reactions, metal catalytic coupling reactions, etc., to expand the structural diversity of pyridine derivatives, provide more strategies and options for the design of organic synthesis routes, and help create organic compounds with novel structures and unique properties, promoting the continuous development of organic synthesis chemistry.

The synthesis method of 6-bromo-5-fluoropyridine-2-carboxylic acid methyl ester (METHYL 6-BROMO-5-FLUOROPYRIDINE-2-CARBOXYLATE) has been recorded in many books in the past, and this is a detailed description for you.
One method can be started from 6-hydroxy-5-fluoropyridine-2-carboxylic acid methyl ester. First, use an appropriate halogenated reagent, such as phosphorus tribromide or hydrobromic acid, in combination with an appropriate amount of oxidizing agent, so that the hydroxyl group is brominated. This process requires attention to the reaction temperature and the amount of reagent. If the temperature is too high or the reagent is too excessive, it may cause side reactions and cause the product to be impure. Usually under mild heating conditions, when the reaction number is stirred, the reaction progress is monitored by thin-layer chromatography, and the reaction can be stopped when the raw material point almost disappears. Then the pure target product can be obtained by conventional separation methods such as extraction, washing, drying, and column chromatography.
The second method is to use 5-fluoropyridine-2-carboxylic acid methyl ester as the starting material. The pyridine ring is activated first, which can be achieved by introducing an appropriate activating group on the pyridine nitrogen atom. After that, the bromination reaction is carried out with a brominating agent, such as N-bromosuccinimide (NBS), in the presence of light or a free radical initiator. The reaction system needs to maintain an anhydrous and oxygen-free environment to avoid unnecessary side reactions. After the reaction is completed, the target product 6-bromo-5-fluoropyridine-2-carboxylic acid methyl ester can also be obtained through similar separation and purification steps.
Another method is to start from pyridine derivatives and construct the desired substituent through multi-step reaction. Fluorine atoms are first introduced in a suitable reaction, followed by bromine atoms and carboxyl methyl ester groups. Although this process is complicated, if the reaction conditions of each step are precisely controlled, high yield and purity products can be obtained. The synthesis path needs to be carefully selected according to factors such as the availability of raw materials, cost and reaction difficulty.

What you are inquiring about is the market price of methyl 6-bromo-5-fluoropyridine-2-carboxylate (METHYL 6-BROMO-5-FLUOROPYRIDINE-2-CARBOXYLATE). However, the market price often changes due to many factors, making it difficult to determine the value.
First, the source of the material has a great influence. If the raw materials are easy to obtain and the supply is sufficient, the price may be stable and low; if the raw materials are scarce, difficult to harvest, and need to be purchased at a high price, the price of the finished product will increase.
Second, the difficulty of preparation is related to the cost. If the preparation of this compound is complicated, the conditions are harsh, it requires multiple steps and time-consuming, and the investment of manpower and material resources is large, its price will be high; if the preparation is simple and the time-consuming is short, the price may be relatively easy.
Third, the supply and demand of the city is also the key. There are many people who want it, and there are few people who supply it, so the price will rise; if the market is saturated, the supply will exceed the demand, and the price will decline.
Fourth, the price varies in different places. In prosperous economic places, the price may be slightly higher if the goods are smooth and the demand is strong; in remote places, the transportation is inconvenient and the demand is small, and the price may be slightly lower.
In summary, in order to know its accurate market price, it is necessary to carefully investigate the supply of raw materials, preparation processes, market supply and demand, and regional differences, or consult chemical material suppliers and traders to obtain a near-real price.

Methyl 6-bromo-5-fluoropyridine-2-carboxylate (METHYL 6-BROMO-5-FLUOROPYRIDINE-2-CARBOXYLATE) is a key compound in the field of organic synthesis. Its physicochemical properties are as follows:
- ** Properties **: Usually white to pale yellow solid or crystalline, this appearance characteristic is closely related to the arrangement and interaction of atoms in the molecular structure. Intermolecular forces prompt it to form a specific crystal structure, resulting in this appearance.
- ** Melting point **: The melting point of this compound is in a specific range, which is determined by the strength of the intermolecular attractive force. The chemical bonds within molecules and the interactions between atoms require a specific energy to break the lattice, causing it to change from solid to liquid. This specific temperature is the melting point.
- ** Boiling point **: When the temperature rises to a certain level, the molecule obtains enough energy to overcome the intermolecular forces, and the compound converts from liquid to gaseous state. This temperature is the boiling point. The boiling point reflects the strength of the intermolecular forces.
- ** Solubility **: Shows good solubility in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc. Because these organic solvents and 6-bromo-5-fluoropyridine-2-carboxylic acid methyl ester molecules can form interactions such as van der Waals forces and hydrogen bonds, which help them to disperse uniformly in the solvent. However, the solubility in water is poor, and it is difficult to form effective interactions because the molecular polarity matches the polarity of water molecules poorly.
- ** Stability **: It has certain stability under conventional conditions, but it needs to avoid contact with strong oxidants, strong bases and other substances. Because strong oxidants may initiate oxidation reactions and change the molecular structure; strong bases may promote the hydrolysis of ester groups, destroy the original structure of molecules, and cause chemical changes. < Br > - ** Reactivity **: The bromine atom, fluorine atom and ester group in the molecule give it a variety of reactivity. Bromine atom can participate in nucleophilic substitution reaction, fluorine atom can affect the reactivity and selectivity due to high electronegativity, and ester group can undergo hydrolysis, alcoholysis, aminolysis and other reactions, providing a rich path for organic synthesis.

Methyl 6-bromo-5-fluoropyridine-2-carboxylate (METHYL 6-BROMO-5-FLUOROPYRIDINE-2-CARBOXYLATE) is a commonly used raw material for organic synthesis. Many matters need to be paid attention to during storage and transportation.
First, when storing, be sure to store in a cool, dry and well-ventilated place. Because of its certain chemical activity, high temperature and humid environment are prone to deterioration. If it is damp, or causes reactions such as hydrolysis, it will damage its quality and performance, so moisture prevention is extremely critical. It can be sealed packaging or placed in a storage place.
Second, keep away from fire and heat sources. This compound is flammable, in case of open flame, hot topic or cause combustion and explosion, threatening personal and property safety. Fireworks should be strictly prohibited in the warehouse, and electrical equipment must also meet the requirements of fire prevention and explosion prevention.
Third, the transportation process should ensure that the packaging is complete and sealed. Avoid material leakage caused by package damage, pollute the environment, and leak materials or react with other substances, causing danger. The means of transportation should be clean and dry, and should not be mixed with oxidants, acids, etc., because of its or violent reaction with these substances.
Fourth, storage and transportation personnel should be professionally trained to be familiar with the chemical characteristics, safety operating procedures and emergency treatment methods. In the event of leakage, fire and other accidents, they can respond quickly and correctly to reduce losses and hazards.
Fifth, regularly check the storage place and transportation means. Check whether the packaging is damaged, whether the material has deteriorated, find and deal with potential problems in time, and ensure the safety of storage and transportation. In this way, the safety and stability of 6-bromo-5-fluoropyridine-2-carboxylate methyl ester during storage and transportation can be ensured.