Methyl 6-amino-5-bromopyridine-2-carboxylate

Methyl-6-amino-5-bromopyridine-2-carboxylic acid ester, which is a crucial compound in the field of organic synthesis, has a wide range of uses.
First, in the field of pharmaceutical chemistry, it is often used as a key intermediate. The construction of many drug molecules depends on its participation in the reaction to introduce specific structural fragments, which in turn endows the drug with specific activity and function. For example, when developing drugs with antibacterial, anti-inflammatory and other effects, the compound can be reacted with other reagents to construct a complex drug molecular structure that meets the needs, helping to develop more targeted and better therapeutic drugs.
Second, in the field of materials science, it also has a good performance. It can be used as a starting material for the synthesis of special functional materials. After specific reactions, materials with unique photoelectric properties and thermal stability can be generated. It can be used to prepare new luminescent materials, semiconductor materials, etc., to provide assistance for the innovation and development of materials science.
Third, in the study of organic synthesis methodologies, methyl-6-amino-5-bromopyridine-2-carboxylate is often used as a model substrate. With the help of in-depth investigation of the various reaction conditions and reaction mechanisms involved, researchers develop new and efficient organic synthesis methods, promote the continuous progress of organic chemical synthesis technology, and provide effective ways for the synthesis of more complex organic compounds.

There are many ways to synthesize methyl 6-amino-5-bromopyridine-2-carboxylic acid esters. Today, it is Ru Chen's first method, in ancient Chinese.
First take pyridine as the group and introduce the carboxyl group at the second position of the pyridine ring. Under specific conditions, the carboxylation reaction can be carried out through pyridine and carbon dioxide under the power of a suitable catalyst to obtain pyridine-2-carboxylic acid. Then, when the bromine atom is introduced at position 5, the pyridine-2-carboxylic acid can be reacted with a brominating agent, such as bromine or N-bromosuccinimide (NBS), in a suitable solvent, such as dichloromethane, with the help of a catalyst or light, to obtain 5-bromopyridine-2-carboxylic acid.
Then 5-bromopyridine-2-carboxylic acid is mixed with methanol, an appropriate amount of concentrated sulfuric acid is added as a catalyst, and the reflux is heated to promote the esterification reaction to obtain methyl 5-bromopyridine-2-carboxylic acid ester. Finally, methyl 5-bromopyridine-2-carboxylic acid ester is reacted with ammonia source, such as liquid ammonia or ammonia water, under a certain temperature and pressure, and the amino group is substituted for the atom or group in the appropriate position to obtain methyl 6-amino-5-bromopyridine-2-carboxylic acid ester.
This is one of the synthesis methods, but the synthesis method does not stop there, or there are other paths according to different starting materials and reaction conditions.

Methyl 6-amino-5-bromopyridine-2-carboxylic acid ester, this is a kind of organic compound. Its physical properties are crucial, and it is related to many chemical processes and practical applications.
First, the appearance is often white to light yellow crystalline powder under normal temperature and pressure. This color and morphology are quite valuable for visual identification.
Melting point is also an important physical property. Generally speaking, the melting point of this compound is within a certain range, but the exact value will fluctuate slightly depending on the preparation process and purity. This property plays a significant role in identifying the purity and controlling the reaction process. If the melting point deviates from expectations, or implies the presence of impurities, its chemical properties will be affected.
The solubility cannot be ignored either. In organic solvents, such as common ethanol, dichloromethane, etc., it exhibits a certain solubility. This property is conducive to its role as a reactant or product in organic synthesis reactions. By selecting a suitable solvent, the reaction rate and yield can be regulated. However, the solubility in water is poor, because the hydrophobic part of the molecular structure accounts for a large proportion.
In addition, the compound has a certain stability. Under conventional storage conditions, if stored in a cool, dry place away from light, it can maintain the stability of chemical structure and properties for a certain period of time. However, in the case of strong acids, strong bases or high temperature environments, the structure is easily damaged, and chemical reactions occur, resulting in changes in properties.
In summary, the physical properties, appearance, melting point, solubility and stability of methyl 6-amino-5-bromopyridine-2-carboxylic acid esters are of great significance for their applications in organic synthesis, drug development and other fields. Only by deeply understanding these properties can we better apply them to achieve the desired chemical goals.

Methyl-6-amino-5-bromopyridine-2-carboxylic acid ester, this is an organic compound. It has many unique chemical properties.
Looking at its structure, it contains a pyridine ring, which endows the compound with certain stability and conjugation effect. The nitrogen atom of the pyridine ring has lone pairs of electrons, which can participate in various chemical reactions, such as coordinating with metal ions, or acting as electron receptors in nucleophilic substitution reactions. The presence of the amino group adds nucleophilicity to the compound. The nitrogen atom of the amino group has lone pairs of electrons, which can react with electrophilic reagents, such as acylation and alkylation reactions. And the amino group is basic and can react with acids to form salts.
Bromine atom is a strong electron-absorbing group, which will affect the electron cloud distribution of the pyridine ring and reduce the electron cloud density on the ring. Under suitable conditions, bromine atoms can undergo nucleophilic substitution and be replaced by other groups, which is an important reaction path for constructing new compound structures.
Methyl ester groups are also reactive and can undergo hydrolysis reactions to generate corresponding carboxylic acids catalyzed by acids or bases; they can also participate in ester exchange reactions and react with different alcohols to form new esters. In summary, methyl-6-amino-5-bromopyridine-2-carboxylic acid esters exhibit a variety of chemical reactivity due to their functional groups such as amino groups, bromine atoms, pyridine rings and methyl ester groups, and are widely used in the field of organic synthesis. They can be used to prepare various compounds with biological activity or special functions.

Methyl 6-amino-5-bromopyridine-2-carboxylic acid ester is in the market, and its price range cannot be directly determined. The price of this substance varies for various reasons.
First, it is related to its purity. If the purity is high and the preparation is difficult, the price will be high; if the purity is slightly lower, the preparation is easy, the price or slightly cheaper.
Second, the supply and demand of the market is also the main reason. If there are many demands and few suppliers, the price will increase; if the supply exceeds the demand, the price will drop.
Third, the preparation method also has an impact. The complicated and expensive method makes the price high; the simple and easy method can make the price low.
Looking at the past records in "Tiangong Kaiwu", the price of all kinds of things varies with various conditions. The same is true for methyl 6-amino-5-bromopyridine-2-carboxylate. Roughly speaking, the price per gram may range from tens to hundreds of yuan. However, this is only a rough estimate. The actual price must be carefully observed in the current market situation and asked all kinds of suppliers before it can be determined.