methyl 5-hydroxypyridine-2-carboxylate

Methyl-5-hydroxypyridine-2-carboxylic acid ester is one of the organic compounds. It has a wide range of uses and has important applications in many fields.
In the field of medicine, it may be the key intermediate for the synthesis of specific drugs. From the perspective of ancient pharmacy, drug synthesis is like the preparation of elixir, and each component needs a delicate ratio. Methyl-5-hydroxypyridine-2-carboxylic acid esters can participate in the construction of complex drug molecular structures due to their unique chemical structure, thus endowing drugs with specific pharmacological activities, or can be used to treat difficult diseases, such as some stubborn diseases, to help doctors find new healing methods.
In the field of materials science, it can be used as a raw material for the synthesis of new functional materials. Just as in ancient times, building a pavilion required selected high-quality materials, today's material synthesis also requires high-quality raw materials. Based on this compound, or materials with special properties can be synthesized, such as materials that have a unique response to external stimuli such as light, electricity, heat, etc., can be applied to advanced electronic devices, intelligent sensing devices, etc., to promote the progress of science and technology, just like the ancients pursued the exquisite skills and constantly opened up new possibilities.
In addition, in the fine chemical industry, it is also often used as an important reaction reagent. Fine chemicals are like the fine workmanship of ancient times, with strict requirements on raw materials and reactions. Methyl-5-hydroxypyridine-2-carboxylic acid esters can participate in various fine chemical reactions, assist in the synthesis of high-value-added fine chemicals, such as special fragrances, high-end paint additives, etc., enrich the variety of chemical products, satisfy the world's pursuit of quality life, just like the ancient people's yearning for exquisite life, embellishing life with various delicate things.

Methyl-5-hydroxypyridine-2-carboxylic acid ester is an important compound in organic chemistry. Its physical properties are unique and it is related to many chemical applications.
Looking at its appearance, it is often in the state of white to light yellow crystalline powder. This color and morphology are crucial for the identification and preliminary determination of the compound. At room temperature, this substance exists in solid form with good stability and is easy to store and transport.
When it comes to melting point, methyl-5-hydroxypyridine-2-carboxylic acid ester has a specific melting point range, and usually undergoes a phase transition from solid to liquid in a certain range. This melting point characteristic is of great significance for its purity identification. The higher the purity, the closer the melting point approaches the theoretical value, and the smaller the fluctuation range.
Solubility is also one of its important physical properties. This substance has different solubility in organic solvents. In common organic solvents such as ethanol and acetone, it has a certain solubility and can form a uniform solution. This property facilitates its use as a reactant or intermediate in organic synthesis reactions, making the reaction easier to carry out in a homogeneous system. However, the solubility in water is relatively poor, because its molecular structure contains hydrophobic groups, and the interaction with water molecules is weak.
In addition, the density of methyl-5-hydroxypyridine-2-carboxylic acid esters also has specific values. Although in practical applications, the density properties are not as common as melting point and solubility, but in some cases involving accurate measurement and mixing ratio of substances, density data is indispensable, which helps to accurately prepare the reaction system and ensure the accuracy of the experiment or production process.

The synthesis method of methyl-5-hydroxypyridine-2-carboxylic acid ester has been studied by many ancient people, and it is detailed by you today.
First, 5-hydroxypyridine-2-carboxylic acid is used as the starting material. First, dissolve it in an appropriate amount of organic solvent, such as dichloromethane or N, N-dimethylformamide, both of which are good solvents, which can fully disperse the raw materials. Then, add an appropriate amount of methylating reagents, such as iodomethane or dimethyl sulfate. The reaction system needs to be carried out under alkaline conditions, and potassium carbonate or sodium carbonate can be used as a base to promote the reaction. The reaction temperature is also very critical, generally controlled between room temperature and 50 ° C, and the reaction is completed for several hours. After monitoring the reaction, the product is separated and purified by conventional extraction, washing, drying, column chromatography, etc., and the target product can be obtained. Methyl-5-hydroxypyridine-2-carboxylate.
Second, start from pyridine. First, pyridine is selectively hydroxylated. This step can use a specific oxidant and catalyst system to introduce hydroxyl groups into pyridine at the 5 position to generate 5-hydroxypyridine. Subsequently, the carboxylation reaction of 5-hydroxypyridine is carried out. The common method is to use carbon dioxide as the carboxyl source and realize it under the action of suitable bases and catalysts. Finally, the methylation reaction is carried out. Just like the methylation step in the first method, the appropriate methylation reagent and base are selected, and the methyl-5-hydroxypyridine-2-carboxylic acid ester can be obtained after a series of post-treatment operations.
Third, some special heterocyclic synthesis strategies can also be used. For example, while the pyridine ring is constructed by multi-component reaction, the hydroxyl group and the carboxyl group are introduced, and then the methylation is carried out. Such methods often require precise control of the reaction conditions and the ratio of reactants. Although the steps are complicated, they have the advantages of high atomic economy. Through careful regulation of each step of the reaction, methyl-5-hydroxypyridine-2-carboxylate can finally be successfully synthesized.

The price range of methyl-5-hydroxypyridine-2-carboxylic acid ester in the market is difficult to determine with certainty. The price of this compound is often influenced by many factors.
First, the purity has a great impact on the price. If the purity is very high and almost perfect, it can be applied to high-end scientific research or special industrial use, and the price is high; on the contrary, the purity is slightly inferior, and it can only be used for general basic research or ordinary industrial processes, and the price is relatively low.
Second, the situation of market supply and demand is also the key. If the demand for methyl-5-hydroxypyridine-2-carboxylic acid ester is strong at a certain time, but the supply is limited, just like the principle that scarcity is expensive, the price will rise; on the contrary, if the supply exceeds the demand and the market is saturated, the price will inevitably decline.
Third, the difficulty of preparation and cost are also closely related. If the preparation requires complicated processes, expensive raw materials or special equipment, the cost will increase greatly, and the price will also be high; if the preparation is relatively simple and the cost is controllable, the price may be close to the people.
Looking at the past market, the price of methyl-5-hydroxypyridine-2-carboxylate varies from a few yuan to several hundred yuan per gram. However, this is only a rough figure, and the market is changing, and the current price may not be comparable at that time. To know the exact price, you need to consult the chemical raw material suppliers in detail and compare the quotations of all parties to obtain a more accurate price range.

Methyl-5-hydroxypyridine-2-carboxylic acid ester is an important compound in organic chemistry. Its storage conditions are quite critical, which is related to the stability and quality of this substance.
According to the concept of "Tiangong Kaiwu", the storage of all substances needs to be checked for their properties. Methyl-5-hydroxypyridine-2-carboxylic acid ester has certain chemical activity and is more sensitive to environmental factors. Therefore, when stored in a cool place, because the temperature is too high, it is easy to cause chemical reactions, cause structural changes, and damage its quality. It is advisable to keep the storage temperature constant and not higher than a specific value. Generally speaking, 2-8 ° C is the best.
Furthermore, this substance should be protected from light. Light can initiate photochemical reactions, causing it to decompose or deteriorate. Therefore, the storage place should be a light-shielding container or stored in a dark room.
Humidity is also critical. Moisture can make it absorb moisture or react with water. It is necessary to store in a dry place, and the relative humidity should be controlled between 40% and 60%. A desiccant can be placed in the storage place to keep the environment dry.
In addition, the storage place should be well ventilated. Avoid potential chemical reactions caused by local gas accumulation. And this substance should be kept away from fire sources, oxidants, etc., to prevent fire or violent chemical reactions. Therefore, the methyl-5-hydroxypyridine-2-carboxylate must be properly stored to maintain its quality and activity.