methyl 5-chlorothieno[2,3-c]pyridine-2-carboxylate

Methyl 5 - chlorothieno [2,3 - c] pyridine - 2 - carboxylate is an organic compound with a wide range of uses. In the field of medicinal chemistry, this compound can be regarded as a key intermediate. Pharmaceutical developers often use it as a starting material and use many organic synthesis methods to carefully construct more complex drug molecules. Due to the specific chemical structure of this compound, including thiophenopyridine ring and carboxyl methyl ester group, it can endow the synthesized drug with unique biological activities, such as potential antibacterial, anti-inflammatory or anti-tumor activities.
In the field of materials science, methyl 5 - chlorothieno [2,3 - c] pyridine - 2 - carboxylate is also useful. Researchers can introduce it into the structure of polymer materials through specific reactions, thereby improving the properties of materials. For example, the photoelectric properties of the material may be improved, making the material suitable for optoelectronic devices such as organic Light Emitting Diodes (OLEDs) or solar cells. The structural properties of this compound may affect the charge transfer and energy conversion efficiency in the material, so it is of great significance in the research and development of new optoelectronic materials.
In addition, in the field of organic synthetic chemistry, methyl 5-chlorothieno [2,3-c] pyridine-2-carboxylate is an important building block, which can participate in many classical organic reactions, such as nucleophilic substitution reactions, metal-catalyzed coupling reactions, etc. Through these reactions, chemists can skillfully construct complex organic molecular structures with different functional group modifications, providing a rich material basis and synthetic strategies for the development of organic synthetic chemistry.

The synthesis methods of methyl-5-chlorothiopheno [2,3-c] pyridine-2-carboxylic acid esters are various, and they are described in detail below.
First, thiophenopyridine is used as the starting material. Before placing thiophenopyridine in a suitable reaction vessel, adding an appropriate amount of halogenating reagents, such as chlorine-containing halogenating agents, at a suitable temperature and reaction time, the halogenation reaction occurs, and the chlorine atom can be introduced at a specific position of thiophenopyridine to generate 5-chlorothiophenopyridine. Subsequently, the product and the reagent containing carboxyl methyl ester are reacted with temperature control in an appropriate organic solvent in the presence of a base catalyst to induce esterification of the two, thereby obtaining methyl-5-chlorothiopheno [2,3-c] pyridine-2-carboxylic acid ester.
Second, starting from pyridine compounds. Select suitable pyridine derivatives, through a specific substitution reaction, first construct the thiophene ring structure. This process requires precise control of the reaction conditions, so that the thiophene ring is connected to a specific position of pyridine to form a thiophene-pyridine structure. Then, like the former, chlorine atoms are introduced through halogenation reaction, and then esterification reaction is carried out to obtain the final target product. When halogenating, attention should be paid to the amount of halogenating agent and reaction temperature to prevent over-halogenation; when esterification, the choice of solvent and the type and amount of alkali catalyst have a significant impact on the reaction yield.
Third, the step-by-step construction method is adopted. First, the intermediates containing thiophene fragments and pyridine fragments are synthesized, and the two are gradually connected by ingeniously designing the reaction route. The thiophene-pyridine parent nucleus is formed first, and then the chlorine atom and the carboxyl methyl ester group are introduced respectively. This process requires careful planning of the reaction sequence and conditions of each step to ensure the selectivity and yield of each step in order to efficiently synthesize methyl-5-chlorothieno [2,3-c] pyridine-2-carboxylate.

Methyl 5-chlorothiopheno [2,3-c] pyridine-2-carboxylic acid ester, this is an organic compound. Its physical properties are crucial and related to many practical applications.
Looking at its appearance, it often takes the form of a white to light yellow crystalline powder, which is more common in many organic synthesis products. Powder-like substances, whose particles are fine and have a large specific surface area, can provide more reaction check points in chemical reactions, and are more fully contacted with other reagents, which in turn affects the reaction rate and effect.
The melting point is usually in a specific range, between about 130 and 135 ° C. The melting point is an important physical property of the compound and can be used for purity identification. If the compound has high purity, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point will be reduced and the melting range will be widened. By accurately measuring the melting point, it can be determined whether the purity of the substance meets the requirements.
In terms of solubility, the substance is slightly soluble in water. Water is a common solvent, which indicates that its dispersion in water is limited, which is related to the functional groups contained in the molecular structure. The structures of thiophene, pyridine ring and ester group in the molecule make it hydrophobic. However, it is soluble in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). Dichloromethane has good solubility and can dissolve many organic compounds. Its molecular structure is relatively simple, and it interacts with the molecules of the compound appropriately, which is helpful for dispersion and dissolution. DMF is a strong polar aprotic solvent, which has good solubility for compounds containing polar groups. The ester group in this compound can form an intermolecular interaction with DMF, thereby dissolving it.
In addition, the density of this compound is also a specific value. Although the exact value will vary slightly due to the measurement conditions, under similar conditions, its density is of great significance for determining the position of the substance in the mixture and calculating the dosage when participating in the reaction. Different densities will present delamination and other phenomena in liquid mixtures, providing a basis for separation and purification.

What you are asking about is the market price of methyl 5 - chlorothieno [2,3 - c] pyridine - 2 - carboxylate. However, I have not found a direct record of this substance in "Tiangong Kaiwu". Due to the difference between ancient and modern times, there was no such fine chemical substance at that time.
In today's world, the price of chemical substances is affected by many factors. First, the cost of raw materials. If the raw materials required for its preparation are scarce and expensive, the price of the finished product will be high. Second, the difficulty of preparation. Those with complicated preparation processes and harsh conditions require more manpower, material resources and financial resources, and the price will also rise. Third, the supply and demand of the market. If there are many seekers and few suppliers, the price will be high; on the contrary, if the supply exceeds the demand, the price will fall.
And this substance may have different demand in different fields due to different uses. For scientific researchers, the purity requirements are extremely high, and the price may be expensive; for industrial large-scale production, considering cost factors, the price may vary.
Due to the changing market situation, prices vary from place to place, and trade policies vary, it is difficult to determine the exact market price. To know the details, it is necessary to consult the current chemical market, relevant trading platforms, and industry merchants in detail to obtain a more accurate price.

Methyl 5-chlorothiopheno [2,3-c] pyridine-2-carboxylic acid ester, the manufacturer of this product, in today's chemical industry, is quite numerous.
In the past, the chemical industry relied on Fang's research, based on ancient methods, and gradually improved. Today is different from the past, science and technology are prosperous, and many manufacturers have the ability to make this product.
Like in Europe and the United States, there are large factories involved in chemical industry for a long time. Over the years, they have studied the production method of this compound and produced this excellent product with exquisite craftsmanship. It is well-equipped and strictly controlled. The methyl 5-chlorothiopheno [2,3-c] pyridine-2-carboxylic acid ester produced is of high quality and is praised by the industry.
Furthermore, Asian countries are also leaders in this industry. Some factories introduce new technologies and optimize production processes with the intention of innovation. Although they started later than Europe, America and the United States, they caught up, and the products they produced are not inferior to others. It can adjust the output in a timely manner according to the needs of the market and supply all parties.
There are also emerging manufacturers who focus on the research and development and production of this compound with specialization. Although the scale may not be as large as that of large factories, they are quite attentive to the technical details. With a flexible strategy, gain a place in the market.
Overall, the manufacturers of methyl 5-chlorothiopheno [2,3-c] pyridine-2-carboxylate are widely distributed, and each has its own capabilities to promote the prosperity of this industry.