methyl 5-bromo-2-oxo-1,2-dihydropyridine-3-carboxylate

Methyl 5-bromo-2-oxo-1,2-dihydropyridine-3-carboxylic acid esters, this compound has a wide range of uses in the field of organic synthesis. First, it can be used as a key intermediate to prepare other nitrogen-containing heterocyclic compounds. The structural characteristics of the Geynepyridine ring with ester groups and bromine atoms can be used to construct more complex heterocyclic structures through many chemical reactions, such as nucleophilic substitution and cyclization. For example, bromine atoms can be substituted with nucleophiles to introduce different functional groups, laying the foundation for the synthesis of various bioactive molecules.
Second, in the field of medicinal chemistry, such compounds may have potential biological activities. Pyridine ring is an important structural unit of many drug molecules. After structural modification and optimization, this compound may be able to develop new drugs with specific pharmacological effects, such as antibacterial, anti-inflammatory, anti-tumor and other drugs.
Third, in the field of materials science, by polymerizing it or compounding it with other materials, it may endow materials with unique optoelectronic properties, which is expected to be applied to organic optoelectronic materials. Because of the interaction between different functional groups in the structure, or the regulation of the electron cloud distribution and energy level structure of the material, it exhibits special optical and electrical properties.

The synthesis methods of methyl 5-bromo-2-oxo-1,2-dihydropyridine-3-carboxylic acid esters are many different, and the advantages and disadvantages of each method are mutual, so it is necessary to choose according to the actual situation.
First, the corresponding pyridine derivatives are used as the starting material and obtained by a series of reactions such as halogenation, oxidation and esterification. First, the parent pyridine is halogenated under suitable conditions with brominating reagents to obtain 5-bromopyridine intermediates. This step requires careful selection of brominating agents, such as bromine, N-bromosuccinimide (NBS), etc., and temperature control and time control to achieve optimal yield and high selectivity. After the oxidation step, the specific position on the pyridine ring is oxidized to a carbonyl group. Commonly used oxidants such as potassium permanganate, potassium dichromate, etc. However, such strong oxidants or side reactions require fine regulation of the reaction conditions. Finally, it reacts with methanol and esterification reagents to achieve esterification and obtain the target product. The raw materials of this method are easy to obtain, but the steps are complicated, the reaction conditions are harsh, and the total yield may be limited.
Second, the pyridine ring is constructed by cyclization reaction. Using compounds with specific structures such as carbonyl, amino and bromine atoms as starting materials, under acidic or basic catalysis, through intramolecular cyclization, the pyridine ring is constructed in one step, and the desired substituent is introduced at the same time. This strategy requires precise design of the starting material structure, and strict control of the reaction conditions, such as acid-base strength, temperature, solvent, etc., all of which have a great impact on the selectivity and yield of cyclization. The advantages are that the steps are simple, the atomic economy is good, but the synthesis of raw materials may be challenging.
Third, metal catalytic coupling reactions are also commonly used. Halogenated pyridine derivatives and reagents containing carboxyl groups and ester groups are coupled in the presence of metal catalysts (such as palladium, copper, etc.) and ligands. This process is critical to the activity and selectivity of metal catalysts, and the structure of ligands also has a significant impact on the reaction. The reaction conditions are relatively mild, the yield and selectivity may be considerable, but the cost of the metal catalyst is high, and the post-reaction treatment may require the removal of metal residues.

Methyl 5-bromo-2-oxo-1,2-dihydropyridine-3-carboxylic acid ester, this substance is an organic compound with specific physical properties. It is a crystalline solid, stable at room temperature, and prone to danger in case of hot topics, open flames or strong oxidants.
Looking at its appearance, it is mostly white to light yellow crystalline powder, delicate and uniform, or shiny under light.
In terms of melting point, it is about 160-165 ° C. This property is of great significance for the identification and purity judgment of compounds. Because the melting point of pure substances is fixed, if impurities are mixed, the melting point may drop and the melting range may be elongated.
In terms of solubility, it is insoluble in water, but easily soluble in common organic solvents, such as dichloromethane, chloroform, acetone, etc. This property allows for the selection of suitable organic solvents to help dissolve and participate in the reaction in organic synthesis, and also facilitates subsequent separation and purification.
As for the density, it is about 1.6-1.7 g/cm ³. Although it is not a very common parameter, it may be a key consideration in specific studies, such as phase equilibrium and hydrodynamic studies.
In addition, this substance has a weak special odor, but the odor is usually not pungent and does not cause strong discomfort.

Methyl 5-bromo-2-oxo-1,2-dihydropyridine-3-carboxylic acid ester, this is an organic compound with unique chemical properties.
Its structure contains a pyridine ring with bromine atoms, carbonyl groups and ester groups. Bromine atoms are highly active and can initiate nucleophilic substitution reactions. Nucleophilic reagents such as alcohols and amines can replace bromine atoms to form new derivatives. This reaction is crucial in the construction of complex organic molecules and can introduce different functional groups. < Br >
The carbonyl group is active and can participate in the reduction reaction. If it is used as a suitable reducing agent, it can be reduced to a hydroxyl group, which can change the chemical activity and properties of the molecule. It can also carry out nucleophilic addition reaction, and the nucleophilic reagent attacks the carbonyl carbon to expand the molecular structure.
The ester group is also important and can undergo hydrolysis reaction under acidic or basic conditions. When acidic hydrolysis, carboxylic acids and alcohols are formed; when alkaline hydrolysis, carboxylic salts and alcohols are obtained. This property is widely used in organic synthesis and drug preparation.
In addition, the pyridine ring of the compound gives it a certain aromaticity, which affects the physical and chemical properties. For example, it has specific solubility in some solvents, which also plays a role in molecular stability Due to its diverse chemical properties, it has potential application value in medicinal chemistry, materials science, and other fields. It can be used as a synthetic intermediate to build more complex compounds with specific functions.

The price of "methyl 5 - bromo - 2 - oxo - 1,2 - dihydropyridine - 3 - carboxylate" is the market price you are inquiring about. However, the price of this product is difficult to determine quickly.
The price of the cover often changes due to many reasons. First, the price fluctuation of the raw materials has a great impact. If the price of the various raw materials required for the synthesis of this product rises or falls, the price of the finished product will change accordingly. Second, the method of preparation is also the key. If there is a new and ingenious method that can reduce the consumption and cost of its preparation, the price may be reduced; conversely, if the preparation is difficult and the cost is high, the price must be high.
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Therefore, in order to know the exact price of this product, it is necessary to carefully investigate the market conditions of raw materials, the difficulty of preparation, the situation of supply and demand, and consult all merchants to obtain a more accurate price. It is difficult to say a word to cover its price geometry.