methyl 5-bromo-2-chloro-pyridine-4-carboxylate

Methyl-5-bromo-2-chloro-pyridine-4-carboxylic acid ester, which has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of specific drugs. In the development process of many innovative drugs for specific diseases, it can be used as a starting material to build a molecular structure with specific biological activities through delicate chemical reactions, and then accurately act on disease targets to help drugs exert therapeutic effects.
In the field of pesticide chemistry, it also plays an important role. Through a series of chemical transformations, highly efficient and low-toxic pesticide active ingredients can be derived. Such ingredients can effectively resist crop diseases and pests, ensure the growth of crops, improve yield and quality, and provide a strong guarantee for agricultural harvests.
In addition, it also has its place in the field of materials science. Through clever chemical modification, materials with special properties can be prepared, such as functional materials with high selectivity for specific substances, which show potential application value in sensors and other fields, injecting new vitality into the development of materials science.

The method of preparing methyl 5-bromo-2-chloro-pyridine-4-carboxylate is an important matter in organic synthesis. In the past, compounds containing pyridine structures were often used as starting materials.
First, take pyridine-4-carboxylic acid as a group, and carry out a step-by-step halogenation reaction with a suitable halogenating agent, such as a brominating agent and a chlorinating agent. First, the pyridine-4-carboxylic acid is interacted with a brominating agent under suitable conditions, and N-bromosuccinimide (NBS) can be selected. In a suitable solvent, such as dichloromethane, heating or light is used to promote the substitution of bromine atoms in the 5th position. Then, chlorination reagents, such as thionyl chloride and phosphorus oxychloride, are used to introduce chlorine atoms at the second position at a suitable temperature and in the presence of a catalyst. Finally, the esterification reaction is carried out with methanol and suitable catalysts, such as concentrated sulfuric acid or p-toluenesulfonic acid, to obtain the target product methyl 5-bromo-2-chloro-pyridine-4-carboxylate.
Second, 2-chloro-5-nitropyridine can also be used as the starting material. The nitro group is first reduced to an amino group, and the common method is iron powder, hydrochloric acid or catalytic hydrogenation. After obtaining 2-chloro-5-aminopyridine, the diazonium salt is formed by diazotization reaction with sodium nitrite and hydrochloric acid at low temperature, and then interacts with reagents such as cuprous bromide to introduce the 5-position bromine atom. Finally, the 4-position carboxylation of the pyridine ring can be introduced by reaction of Grignard reagent with carbon dioxide or hydrolysis after reaction with potassium cyanide, and then esterified with methanol to obtain methyl 5-bromo-2-chloro-pyridine-4-carboxylate.
These two types of methods have their own advantages and disadvantages, and they need to be weighed according to the availability of raw materials, the ease of control of reaction conditions, and the purity of the product.

Methyl 5 - bromo - 2 - chloro - pyridine - 4 - carboxylate is an organic compound, and its physical properties are particularly important, which is related to its performance in various chemical processes and applications.
This compound may be a solid under normal conditions, due to the existence of van der Waals forces and other forces between molecules, resulting in an orderly arrangement of molecules. In terms of melting point, the presence of bromine, chlorine atoms and ester groups enhances the intermolecular forces, so the melting point is relatively high. Bromine and chlorine atoms are highly electronegative and can form dipole-dipole interactions. Ester groups also participate in intermolecular interactions, which together push up the melting point.
The boiling point is also affected by intermolecular forces. The interaction between atoms and functional groups in its structure makes the intermolecular attraction quite large. To make the compound change from liquid to gaseous state, more energy is required to overcome this attraction, so the boiling point is not low.
In terms of solubility, the compound contains ester groups and has a certain polarity. However, the overall polarity is changed due to the influence of bromine and chlorine atoms. In polar organic solvents, such as acetone and ethanol, there may be a certain solubility. Due to the principle of "similar miscibility", polar molecules can form interactions. However, in non-polar solvents, such as n-hexane, the solubility may be very small, due to the weak interaction between polar and non-polar molecules.
Appearance may be white to light yellow solid, which is determined by the characteristics of molecular structure on light absorption and reflection. The electron cloud structure of bromine and chlorine atoms affects the light absorption, resulting in a specific color range in its appearance.
The density is related to the molecular weight and the degree of molecular accumulation. This compound contains heavy atoms of bromine and chlorine, and the molecular weight is large, and the molecular arrangement is relatively tight, so the density may be relatively high, which is heavier than that of common organic solvents.
In summary, the physical properties of methyl 5-bromo-2-chloro-pyridine-4-carboxylate, such as melting point, boiling point, solubility, appearance and density, are determined by its unique molecular structure. These properties are of great significance in chemical synthesis, separation and purification, and practical applications.

Methyl 5-bromo-2-chloropyridine-4-carboxylic acid ester, this product is on the market, and its price is difficult to cover. The price is affected by various factors, such as the difficulty of preparation, the price of raw materials, and the state of market supply and demand.
It is difficult to prepare by yourself. If the synthesis of this compound requires cumbersome steps, harsh reaction conditions, or rare reagents, the cost will rise and the price will be high. And the price of raw materials fluctuates. If raw materials are scarce or difficult to obtain, the price will also fluctuate.
The market supply and demand situation has a deep impact on its price. If the demand is strong and the supply is limited, the merchant will raise the price to obtain more profits; on the contrary, if the supply exceeds the demand, the price will drop in order to sell the inventory.
According to past transactions and market conditions, the price varies from time to time. At a specific time and place, due to various factors, it may be high or low. If you want to know the exact price, you should consult chemical raw material suppliers and chemical trading platforms. The price information can be updated from time to time, and the current market price can be obtained for reference in purchasing or trading.

Methyl 5-bromo-2-chloropyridine-4-carboxylic acid ester, this is one of the organic chemicals. Its storage conditions are very critical, which is related to the stability and quality of this substance.
To properly store methyl 5-bromo-2-chloropyridine-4-carboxylic acid ester, the first thing is to choose a cool and dry place. Because temperature and humidity have a great impact on organic compounds, high temperature and humidity can easily cause them to deteriorate. Therefore, it should be protected from direct sunlight and moisture. If exposed to sunlight or in a place with high humidity, it may cause chemical reactions and damage its structure and purity.
Furthermore, it is advisable to store this substance in a sealed container. This can prevent it from coming into contact with the air, covering the oxygen, water vapor, etc. in the air, or reacting with the compound. A sealed container can effectively isolate external factors and ensure its chemical stability.
In addition, the storage environment should be kept away from fire and heat sources. Methyl 5-bromo-2-chloropyridine-4-carboxylate or flammable, in case of open flame, hot topic, or risk of fire or even explosion.
At the same time, it needs to be stored separately from oxidizing agents, acids, bases and other substances. Because of its active chemical properties, contact with the above substances, or cause violent chemical reactions, endangering safety.
During storage, also do a good job of marking, and remember the name, specification, storage date and other information of the compound in detail. This is convenient for management and traceability. If there is any problem, you can check the cause according to the records.
In short, store methyl 5-bromo-2-chloropyridine-4-carboxylate in a cool and dry place, in a sealed container, away from the source of fire and heat, separate incompatible substances, and mark them well. In this way, the quality and safety of the compound can be ensured.