METHYL 4-CHLORO-2-PYRIDINECARBOXYLATE

Methyl-4-chloro-2-pyridinecarboxylate, an organic compound, is very important in the chemical and pharmaceutical fields. Its physical properties are as follows:
Appearance properties, under normal conditions, it is mostly white to light yellow crystalline powder state, delicate in appearance, smooth to touch, occasionally shimmering under light, just like fine sand covered with thin light. This state is easy to store and access, and also shows that its molecules are arranged in a regular and orderly manner.
In terms of melting point, it is about 48-52 ° C. When heated to this temperature range, the substance will be like winter snow meeting the warm sun, gradually melting from the solid state to the liquid state, the intermolecular force weakens with the increase of temperature, and the lattice structure disintegrates. This melting point characteristic is of great significance for its separation, purification and identification. It is like a unique "thermal fingerprint", which helps chemists to accurately identify it.
The boiling point is usually 230-235 ° C. At this high temperature, the molecule obtains enough energy to break free from the liquid phase and become gaseous. The boiling point is closely related to the attractive force between molecules and the relative molecular mass. This boiling point value reflects the moderate strength of the intermolecular force.
In terms of solubility, it has good solubility in common organic solvents such as ethanol and acetone. It is like a fish entering a river, and the molecules are evenly dispersed to form a uniform and stable solution. However, the solubility in water is limited, like oil floating in water. Due to the poor matching between molecular polarity and water molecules, it reflects its lipophilic and hydrophobic characteristics, and plays a significant role in extraction, reaction medium selection and other operations.
The density is about 1.32 g/cm ³, which is heavier than water. Placing it in water, such as a stone sinking abyss, reflects the tight accumulation of its molecules and the concentration of mass. This density property is indispensable in the measurement of materials in chemical production, separation process design, etc.
In terms of smell, it has a weak special smell, like vanilla mixed with the light fragrance of sweet wood, but it is not comparable to pure floral fragrance. This unique smell originates from the structure of pyridine ring and ester group, which adds a different "chemical smell" to it, but this smell is not pungent and relatively mild. The physical properties of methyl-4-chloro-2-pyridyl carboxylate are key factors in chemical synthesis, pharmaceutical research and development, etc. Chemists can optimize reaction conditions, design separation processes, and explore new uses, just like craftsmen carve treasures based on material properties, making them shine in the process of scientific and technological progress.

Methyl-4-chloro-2-pyridinecarboxylate is one of the organic compounds. It has unique chemical properties, which are described in detail by you.
In this compound, the chlorine atom is connected to the pyridine ring, and the pyridine ring is complex and conjugated with the carboxyl methyl ester group. The chlorine atom has electron-absorbing properties, which can affect the electron cloud density distribution of the pyridine ring. Due to the electron-absorbing effect of chlorine, the electron cloud on the pyridine ring is biased towards the chlorine atom, resulting in a decrease in the electron cloud density of the carbon atom on the ring, especially in the adjacent and counterposition of the chlorine atom. The change of this electron cloud distribution affects the reactivity and check point selectivity of the compound in the electrophilic substitution reaction. In general, electrophilic reagents tend to attack the position where the electron cloud density is relatively high on the pyridine ring. However, due to the localization effect of chlorine, the substitution reaction often occurs at the specific position of the pyridine ring.
methyl ester group (-COOCH 🥰) also has a significant impact on the properties of the compound. It has a certain polarity and can participate in a variety of intermolecular forces, such as dipole-dipole interactions. At the same time, methyl esters can undergo hydrolysis under appropriate conditions to generate corresponding carboxylic acids and methanol. This hydrolysis reaction can be carried out under acid or base catalysis, and hydrolysis is more thorough under alkaline conditions. The caustic base can react with the generated carboxylic acid and push the reaction balance to move towards hydrolysis.
Furthermore, the nitrogen atom of the pyridine ring has a lone pair of electrons, which can be used as an electron donor to participate in coordination chemistry. The compound may form complexes with metal ions, which may have potential applications in catalysis, materials science and other fields. Due to the joint action of the pyridine ring, chlorine atoms and methyl ester groups, the chemical properties of methyl-4-chloro-2-pyridinecarboxylate are rich, laying the foundation for research and application in many fields such as organic synthesis and medicinal chemistry.

METHYL 4-CHLORO-2-PYRIDINECARBOXYLATE, that is, methyl 4-chloro-2-pyridinecarboxylate. Its common synthesis method is an important matter for chemical preparation, let me explain in detail.
In the past, this compound was often synthesized with 2-pyridinecarboxylic acid as the starting material. First, it is esterified with methanol under acid catalysis. In this process, acid acts as a catalyst to accelerate the reaction process, promoting the dehydration and condensation of the carboxyl group of 2-pyridinecarboxylic acid and the hydroxyl group of methanol to form methyl 2-pyridinecarboxylate. However, there is no chlorine atom at the 4 position on the pyridine ring at this time.
Then, methyl 2-pyridinecarboxylate needs to be chlorinated to introduce chlorine atoms. Chlorination methods are diverse, and chlorine gas or chlorine-containing reagents are often reacted under suitable conditions. For example, in a specific solvent, the reaction temperature and time are controlled to make chlorine gas fully react with methyl 2-pyridinecarboxylate, and chlorine atoms are introduced at the 4th position of the pyridinecarboxylate ring to obtain methyl 4-chloro-2-pyridinecarboxylate.
There are also people who use 4-chloro-2-pyridinecarboxylic acid as a raw material and directly react with methanol under similar esterification conditions to obtain the target product. This route is relatively simple, but the acquisition of raw material 4-chloro-2-pyridinecarboxylic acid or other methods also have its advantages and disadvantages.
During the synthesis process, the control of reaction conditions is crucial. Too high or too low temperature can affect the reaction rate and product purity. The choice of solvent should also not be underestimated, and the one with good solubility of the reactants and no adverse effect on the reaction should be selected. And the separation and purification operations after each step, such as distillation, recrystallization, etc., also affect the quality of the final product. In this way, METHYL 4-CHLORO-2 - PYRIDINECARBOXYLATE can be effectively synthesized.

Methyl-4-chloro-2-pyridyl carboxylic acid ester, which is useful in many fields. In the field of pharmaceutical and chemical industry, it is often the key raw material for the creation of drugs. The unique structure of the Gainpyridine ring gives it a variety of biological activities, which can be chemically modified to prepare antibacterial, anti-inflammatory, anti-tumor and other drugs.
In the place where pesticides are developed, there are also its own figures. Using it as a starting material and through exquisite synthesis, high-efficiency pesticides can be obtained. Such pesticides are highly destructive to pests and relatively friendly to the environment. They can protect crops from insect infestation and promote agricultural harvests.
Furthermore, in the field of materials science, it also has a role. It can participate in the preparation of special materials, improve the specific properties of materials, such as stability, conductivity, etc., and contribute to material innovation.
In addition, in the field of organic synthetic chemistry, it is an important intermediate. With its own activity, it can cleverly react with a variety of reagents to construct complex organic molecules, expand the boundaries of organic synthesis, and provide the possibility for the creation of new compounds. In short, methyl-4-chloro-2-pyridyl carboxylate plays an indispensable role in many fields such as chemical industry, medicine, agriculture, materials, etc., and has contributed to the development of various fields.

It is difficult to determine the market price of 4-chloro-2-pyridinecarboxylate. The situation that covers its market price often changes due to various factors.
First, the price of raw materials is fundamental. If the raw material for making this ester is scarce, or its production is disturbed by the weather, geographical location, and government orders, the price will rise. On the contrary, the raw materials are abundant, the supply exceeds the demand, and the price will decline.
Second, the simplicity of the process is also the main reason. If the preparation method requires exquisite skills, high equipment, and time-consuming and laborious, the cost will be high, and the market price will be high. However, if the process is refined, the complexity is simplified, and the cost is controlled, the price may drop.
Third, market supply and demand determine the price. If the demand for this ester in the fields of medicine and chemical industry is strong, but the supply is limited, the price will go up. If the demand is weak, the inventory is overstocked, and the price is difficult to maintain.
Fourth, industry competition has a very strong impact. If there are many merchants in the city competing for a share, the price may be reduced. If there are few competitors, the price can be independent.
Looking at the past, the price of such chemicals often fluctuates. Or because the raw materials are suddenly expensive, the price has increased several times in a few months; or because of the advent of new technologies, the cost has dropped sharply, and the price has also been reduced.
Therefore, in order to know the market price of methyl 4-chloro-2-picolinecarbonate, it is necessary to observe the situation of raw materials, the progress of technology, changes in supply and demand, and the trend of competition in real time, and comprehensively analyze and judge, in order to obtain a more accurate price, it is difficult to generalize its price.