methyl 4-bromothieno[2,3-c]pyridine-2-carboxylate

Methyl 4-bromothiopheno [2,3-c] pyridine-2-carboxylic acid ester is one of the organic compounds. It has a wide range of uses and is often a key intermediate in the synthesis of new drugs in the field of medicinal chemistry. Due to its unique structure, thiophenopyridine endows the compound with diverse biological activities, which can target specific disease targets and assist pharmaceutical chemists in creating new drugs with therapeutic effects.
In the field of materials science, this compound may participate in the synthesis of organic optoelectronic materials. The thiophenopyridine unit has a special electronic structure, which may improve the optical and electrical properties of materials, such as improving the luminous efficiency of organic Light Emitting Diode (OLED) or enhancing the photoelectric conversion efficiency of organic solar cells.
In addition, in the field of organic synthetic chemistry, it is an important building block for the construction of complex organic molecules. With its activity check point of bromine atoms and ester groups, various organic reactions, such as nucleophilic substitution, coupling reactions, etc., can be used to introduce other functional groups or structural fragments to expand the structural diversity of compounds to meet the needs of different fields for specific organic compounds with specific structures and properties.

The synthesis of methyl-4-bromothiopheno [2,3-c] pyridine-2-carboxylic acid esters is quite complicated and requires multiple and delicate reactions to achieve.
The first step is often to use suitable thiophene derivatives as starting materials. This raw material is ingeniously combined with pyridine compounds under specific reaction conditions, such as in a solution with a specific pH. This process requires fine regulation of the reaction temperature and time. The temperature may need to be maintained in a certain precise range, such as tens of degrees Celsius, and the time needs to be precisely controlled to ensure that the two react effectively to form the basic skeleton of thiopheno-pyridine.
Then, the intermediate of thiophenopyridine is modified. In this step, the bromination reaction is particularly critical. Select the appropriate brominating reagent, such as bromine or a specific bromine-containing organic compound, and under the catalysis of a suitable catalyst, the bromine atom is precisely replaced at the target position, that is, the 4-position, so as to obtain 4-bromothiopheno [2,3-c] pyridine derivatives. The conditions of this bromination reaction also need to be strictly controlled. The amount of catalyst and the anhydrous degree of the reaction environment all have a profound impact on the yield and selectivity of the reaction.
Finally, the obtained 4-bromothiopheno [2,3-c] pyridine derivative is reacted with a carboxylic acid methyl esterification reagent. This reaction may need to be carried out in an alkaline environment, and the esterification reaction of the two is promoted by the action of bases, and finally methyl-4-bromothiopheno [2,3-c] pyridine-2-carboxylic acid esters are formed. In this process, the type and dosage of bases, the choice of reaction solvent, etc. are all important factors affecting the effectiveness of the reaction. After each step of the reaction, fine separation and purification methods such as column chromatography and recrystallization are required to ensure the purity of the product, which lays a good foundation for the next reaction.

Methyl 4-bromothiopheno [2,3-c] pyridine-2-carboxylic acid ester, this is an organic compound. Looking at its physical and chemical properties, its shape or solid, because many such organic compounds containing heterocycles and ester groups are solid at room temperature. Its melting point or due to intermolecular forces, it is within a certain range, but the exact value needs to be accurately determined by experiments.
In terms of solubility, due to its molecular structure containing an ester group (-COOCH), the group has a certain polarity, but the thiopheno-pyridine ring has a certain hydrophobicity. Therefore, it may have a certain solubility in organic solvents such as dichloromethane, chloroform, and acetone, because these organic solvents can form appropriate forces with molecules to help them disperse and dissolve. In water, due to the relatively strong hydrophobicity of the overall molecule, the solubility may be quite limited.
Chemically, ester groups can undergo hydrolysis. Under acidic conditions, 4-bromothiopheno [2,3-c] pyridine-2-carboxylic acid and methanol can be formed by hydrolysis; under alkaline conditions, the hydrolysis reaction is easier to proceed, generating carboxylate and methanol, and subsequent acidification can obtain corresponding carboxylic acids. Bromine atoms are also active and can participate in nucleophilic substitution reactions. For example, under appropriate reagents and conditions, bromine atoms can be replaced by other nucleophilic reagents, so as to realize the modification and derivatization of molecular structures, providing the possibility for the synthesis of more complex organic compounds.

The price of methyl 4-bromothiopheno [2,3-c] pyridine-2-carboxylate on the market is difficult to determine. This compound is unusual and common, and its price is determined by many factors.
First, it is related to the difficulty of preparation. If the preparation process is complicated, it needs to go through multiple reactions, and the yield of each reaction is not high, or the required raw materials are rare and difficult to find, and the price is high, it will lead to a significant increase in costs, and its price in the market is not cheap.
Second, the amount of market demand is also the key. If there is a widespread and urgent demand for this compound in the fields of pharmaceutical research and development, materials science, etc., and the demand exceeds the supply, its price will rise; conversely, if there is little demand, the price will also decrease accordingly.
Third, the scale of production also has an impact on the price. In large-scale production, due to the scale effect, the unit cost may be reduced, and the price will tend to be flat; if it is only a small-scale trial production, the cost will not decrease, and the price will remain at a high level.
Using the analogy of "Tiangong Kaiwu", the book talks about various processes and products, emphasizing the relationship between skills, raw materials and output. For this compound, just like the simplicity of the process mentioned in the book determines the quality and cost of the product. However, there is no exact public information to clarify its specific price, and it is necessary to consult professional chemical raw material suppliers, reagent sales platforms, or consult specific market survey reports to obtain more accurate price information.

Methyl-4-bromothiopheno [2,3-c] pyridine-2-carboxylic acid ester is an organic compound. Its storage is essential to the quality and stability of this substance.
First of all, it should be protected from heat, heat can easily cause changes in its chemical structure and damage its characteristics. It should be placed in a cool place, so that the ambient temperature is moderate, and it should not be attacked by heat. And this substance may be sensitive to light, under light, or cause photochemical reactions to cause it to deteriorate. Therefore, it needs to be hidden in a dark place, in an opaque container, or stored in a dark place.
Furthermore, moisture resistance is also the key. Moisture can cause many chemical changes, or hydrolyze the compound, causing it to fail. Store the place must be dry, or use a desiccant in the storage container to keep the environment dry.
In addition, because it is a chemical, it is also necessary to isolate it from other things. Do not coexist with substances that can react with it to prevent unexpected chemical reactions. When storing, it should be classified and placed according to its chemical properties in a strict and orderly manner.
In addition, sealed storage is indispensable. Well sealed, it can prevent the intrusion of air, moisture and other impurities, and maintain its chemical purity and stability.
In summary, the storage of methyl-4-bromothiopheno [2,3-c] pyridine-2-carboxylate must be stored in a cool, dry, dark place, sealed, and isolated from others, so as to protect its quality for later use.