Methyl 4 Bromopyridine 2 Carboxylate
pyridine pyrrole pyrazine piperidine piperazine

Methyl 4-bromopyridine-2-carboxylate

    Specifications

    HS Code

    428259

    Name Methyl 4 - bromopyridine - 2 - carboxylate
    Molecular Formula C7H6BrNO2
    Molecular Weight 216.03
    Appearance Typically a solid (appearance can vary based on purity and synthesis method)
    Cas Number 89485 - 61 - 6
    Melting Point Data may vary, but around 90 - 94 °C (approximate)
    Boiling Point No widely - reported standard value, but decomposition may occur before reaching a typical boiling point due to heat - sensitive nature
    Solubility Soluble in organic solvents like dichloromethane, chloroform; relatively insoluble in water
    Pka No specific value widely reported, but the pyridine nitrogen can be basic
    Density No commonly - reported value, but density is influenced by packing and purity
    Flash Point No widely - reported flash point data, but as an organic compound, it may be flammable under certain conditions

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    Frequently Asked Questions

    As a leading Methyl 4-bromopyridine-2-carboxylate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of Methyl 4-bromopyridine-2-carboxylate?
    Methyl-4-bromopyridine-2-carboxylic acid esters are also organic compounds. There are a few properties, which are described by you today.
    This substance is white to off-white crystalline powder, so its appearance is also. In terms of its chemical activity, the bromine atom in the molecule is quite active, which is easy to be attacked by nucleophiles and triggers nucleophilic substitution reactions. In case of nucleophiles such as hydroxyl negative ions, the bromine atom can be replaced by hydroxyl groups to form corresponding alcohol derivatives.
    Its pyridine ring is aromatic, but it also has certain alkalinity. There are lone pairs of electrons on the nitrogen atom of the edge pyridine, which can accept protons. In an acidic environment, it can combine with protons to form salts. This alkalinity allows the compound to act as a base catalyst or participate in acid-base equilibrium-related reactions in a specific reaction system.
    Furthermore, the ester group is also an important active site of the compound. Under acid or base catalysis conditions, hydrolysis can occur. When catalyzed by acid, it is gradually hydrolyzed to 4-bromopyridine-2-carboxylic acid and methanol; alkali catalyzed hydrolysis is more rapid, resulting in carboxylate and methanol. This hydrolysis property is often used in organic synthesis to introduce carboxylic groups or prepare specific carboxylic acid derivatives.
    In addition, its solubility also has characteristics. It has a certain solubility in common organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide, etc. This property facilitates its participation in various homogeneous reactions and facilitates organic synthesis operations. In short, methyl-4-bromopyridine-2-carboxylate has diverse chemical properties and is widely used in the field of organic synthesis.
    What are the synthetic methods of Methyl 4-bromopyridine-2-carboxylate?
    There are many different methods for synthesizing methyl 4-bromopyridine-2-carboxylic acid esters. One common one is to use pyridine-2-carboxylic acid as the starting material. First, pyridine-2-carboxylic acid is mixed with methanol, concentrated sulfuric acid is used as the catalyst, and the esterification reaction is carried out under the condition of heating and reflux to obtain methyl pyridine-2-carboxylic acid. This process requires attention to the control of reaction temperature and time. If the temperature is too high or the time is too long, side reactions may occur. Then, the methyl pyridine-2-carboxylate is brominated with a brominating agent, such as bromine, in a suitable solvent, such as dichloromethane, at low temperature and initiated by an initiator. During the reaction, the amount of brominating agent and the rate of dropwise addition must be strictly controlled to ensure that the main methyl 4-bromopyridine-2-carboxylate is formed.
    Furthermore, 4-bromopyridine can also be used as a starting material. The nitrogen atom of 4-bromopyridine is first protected to prevent it from participating in unnecessary reactions in subsequent reactions. Commonly used protective groups such as tert-butoxycarbonyl. After protection, carbonylation is carried out with suitable nucleophilic reagents, such as carbon monoxide and methanol under the action of a catalyst. This reaction condition is relatively harsh, and a certain pressure and temperature are required. After the reaction is completed, the protective group is removed to obtain methyl 4-bromopyridine-2-carboxylic acid ester.
    Others use 2-methylpyridine as the starting material. 2-methylpyridine is first brominated, bromine atoms are introduced at the 4th position, and then methyl is oxidized to carboxyl groups with suitable oxidants, such as potassium permanganate, etc. Finally, it is esterified with methanol to obtain the target product. However, there are many steps in this method, and the yield of each step will affect the yield of the final product, and the oxidation step needs to be carefully regulated to prevent excessive oxidation.
    Where is Methyl 4-bromopyridine-2-carboxylate used?
    Methyl-4-bromopyridine-2-carboxylic acid ester, this is an organic compound that has applications in many fields.
    In the field of medicinal chemistry, it has a wide range of uses. Due to the structure of pyridine and carboxylic acid esters, it is endowed with specific chemical activity and molecular recognition ability. It can be used as a key intermediate for the synthesis of many biologically active compounds. For example, it can be converted into drug molecules with potential pharmacological activity by specific chemical reactions, or known drugs can be structurally modified to optimize their pharmacological properties, such as enhancing the efficacy of drugs and reducing toxic and side effects.
    In the field of materials science, methyl-4-bromopyridine-2-carboxylic acid esters are also useful. With their unique chemical structure, they can participate in the synthesis process of polymer materials. For example, polymerization with other monomers can prepare polymer materials with specific properties. These materials may have unique electrical, optical or mechanical properties and are expected to be used in electronic devices, optical materials, etc.
    Furthermore, in the field of organic synthetic chemistry, it is an important synthetic building block. Due to the existence of bromine atoms and carboxylic acid ester groups, more complex organic molecular structures can be constructed through a variety of classical organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc. Chemists can use this to design and synthesize various new types of organic compounds, expand the scope of organic synthesis, and provide important basic raw materials for the creation of new substances.
    What is the market price of Methyl 4-bromopyridine-2-carboxylate?
    The market price of methyl-4-bromopyridine-2-carboxylic acid ester is difficult to determine. The price of this compound is influenced by many factors, just like the situation changes and is unpredictable.
    In the past, the price of chemical raw materials often varied according to time, place, and supply and demand trends. If the weather is good, the origin is abundant and the supply is sufficient, the price may be flat; however, if natural and man-made disasters cause the shortage of raw materials, the price will rise sharply.
    And this compound is widely used, and it is involved in pharmaceutical research and development, fine chemical preparation, etc. In the field of medicine, if the demand for a new drug is surged, and the supply is not enough, the price will also rise.
    Furthermore, market competition is also the key. Manufacturers compete for profits, and the quality of production technology and cost are all related to pricing. Those with exquisite craftsmanship and low cost may be able to win by price, which affects the market price trend.
    In addition, the situation of international trade, the increase or decrease of tariffs and the existence of trade barriers also affect the price. Foreign disputes and changes in trade agreements all make prices volatile. Therefore, in order to know the exact market price of methyl-4-bromopyridine-2-carboxylate, it is necessary to consult the chemical market information in detail, consult industry experts, and pay close attention to raw material supply, demand changes, competition trends, and trade policies.
    What are the storage conditions for Methyl 4-bromopyridine-2-carboxylate?
    Methyl-4-bromopyridine-2-carboxylic acid ester is one of the organic compounds. Its storage is essential, the first environment is dry and cool. Cover this material is afraid of moisture, if it is in a wet environment, or cause deterioration, damage its chemical properties.
    should be placed in a closed container to prevent excessive contact with the air. Oxygen and water vapor in the air may react with it, causing its composition to change. Storage temperature should also be paid attention to, not too high, under high temperature, its stability is easy to lose, or cause decomposition and other reactions. Generally speaking, it should be controlled at room temperature or slightly lower temperature, but it should not be frozen, frozen at low temperature or break its structure.
    In addition, the storage place should be protected from fire and heat sources. This compound may be flammable, and it may be dangerous in case of open flames and hot topics. It should also be stored separately from oxidizing agents, acids, alkalis, etc. Due to its active chemical properties, coexistence with them can easily cause chemical reactions and endanger safety.
    In the storage room, appropriate fire and leakage emergency treatment equipment should be prepared to prevent accidents. Regularly check the storage status. If the package is damaged or leaking, dispose of it quickly and properly to ensure the quality of the product and the safety of the surroundings. In this way, the methyl-4-bromopyridine-2-carboxylic acid ester can be well stored to maintain its performance.