methyl 3-iodopyridine-4-carboxylate

Methyl 3-iodopyridine-4-carboxylic acid ester, also an organic compound. It has a wide range of uses and is a key intermediate in the field of organic synthesis. This compound can be used to construct a variety of complex organic molecular structures. With its activity of iodine atoms and ester groups, it can be used to prepare other nitrogen-containing heterocyclic compounds or biologically active substances through various chemical reactions, such as nucleophilic substitution, coupling reactions, etc.
In the field of pharmaceutical chemistry, it may be the starting material for potential lead compounds. By modifying the pyridine ring and side chain substituents, new compounds with specific pharmacological activities can be created, such as the development of anti-cancer, anti-inflammatory, antibacterial and other drugs. < Br >
In the field of materials science, there may also be applications. After appropriate chemical transformation, materials with special photoelectric properties can be prepared for the research and development of organic Light Emitting Diodes, solar cells and other devices. With its structural properties, the materials are endowed with unique electrical and optical properties.
From this perspective, methyl 3-iodopyridine-4-carboxylic acid esters have important potential value in many fields such as organic synthesis, drug research and development, and material preparation. They are indispensable chemicals for chemical research and industrial production.

The method of synthesizing methyl 3-iodopyridine-4-carboxylic acid ester is an important task in organic synthesis. There are many methods, which can be selected according to many factors such as the availability of raw materials, the difficulty of reaction, and the high or low yield.
First, 3-aminopyridine-4-carboxylic acid ester is used as the starting material. It is first diazotized, and can be reacted with sodium nitrite and acid (such as hydrochloric acid) at low temperature to form a diazonium salt. After interacting with iodine sources such as potassium iodide or cuprous iodide, the diazo group is replaced by iodine atoms through Sandmeier reaction, and then methyl 3-iodopyridine-4-carboxylic acid ester is obtained. This step is slightly more complicated, but the raw materials are easier to obtain and the yield is more considerable.
Second, starting from the pyridine-4-carboxylic acid ester. First introduce a suitable guide group, such as acetyl group, at the 3rd position of the pyridine ring to activate the 3rd position. Then carry out the iodine substitution reaction with an iodine substitution reagent (such as N-iodosuccinimide, etc.) to introduce the iodine atom into the 3rd position. Finally, remove the guide group as appropriate to obtain the target product. This diameter requires stricter reaction conditions, so the reaction check point can be precisely controlled to reduce side reactions.
Third, the coupling reaction catalyzed by transition metals. With 3-halogenated pyridine-4-carboxylic acid esters (such as 3-bromopyridine-4-carboxylic acid esters) and iodizing reagents, under the action of transition metal catalysts and ligands such as palladium and copper, the coupling of carbon-halogen bonds with iodine atoms is realized to generate methyl 3-iodopyridine-4-carboxylic acid esters. This method has mild reaction conditions and high selectivity, but the catalyst cost is high.
All synthesis methods have advantages and disadvantages. In actual operation, it is necessary to consider factors such as raw material cost, reaction conditions, equipment requirements and impact on the environment, and choose the most suitable method to achieve the purpose of efficient, economical and environmentally friendly synthesis of methyl 3-iodopyridine-4-carboxylate.

Methyl-3-iodopyridine-4-carboxylic acid ester, this is an organic compound. Looking at its physical and chemical properties, this substance is usually in a solid state, but it also varies according to specific environmental conditions. Its melting point and boiling point are determined by intermolecular forces and structural characteristics. In this molecule, iodine atoms are connected to pyridine rings and ester groups, and this structure gives it specific physical and chemical properties.
In terms of solubility, due to the ester group, it may have a certain solubility in common organic solvents such as chloroform and dichloromethane, but its solubility in water may be limited. The hydrophobic part of its molecule accounts for a large proportion.
Its chemical properties are active, and the activity of iodine atoms is quite high, which is prone to nucleophilic substitution reactions. Ester groups are also reactive and can undergo hydrolysis, alcoholysis and other reactions. Under appropriate conditions, pyridine rings can also participate in reactions, such as electrophilic substitution reactions. Due to its unique structure, it is often used as a key intermediate in the field of organic synthesis to construct more complex organic molecular structures. Many of its physical and chemical properties are derived from its own molecular structure and the interaction between atoms, which is of great value in the research and application of organic chemistry.

I don't know what the price range of "methyl + 3 - iodopyridine - 4 - carboxylate" is in the market. However, "Tiangong Kaiwu" is an ancient book of science and technology, and it involves most of the skills and products of agriculture and industry. There are few records of the price of such chemical compounds.
In today's world, the price of this compound is affected by many factors. First, the difficulty of its preparation. If the synthesis method is complicated, requires multiple processes, uses rare reagents, or has harsh conditions, the cost will be high and the price will be high. Second, the market demand situation. If an industry has strong demand for this product, the supply will exceed the demand, and the price will rise; conversely, if the supply exceeds the demand, the price will decline. Third, the size of the production scale. Large-scale production may be able to reduce costs through scale effects, and prices may be close to the people; small-scale production, costs are difficult to reduce, and prices may be expensive.
In addition, different suppliers, quality grades, etc., will also cause price differences. To know the exact price range, when consulting chemical raw material suppliers, chemical reagent sales platforms, or professional channels for chemical product price information, you can get an accurate number, which cannot be known only according to "Tiangong Kaiwu".

Methyl 3-iodopyridine-4-carboxylate is an organic compound, and its storage conditions are very critical, which is related to the stability and quality of this compound.
If you want to properly store methyl 3-iodopyridine-4-carboxylate, you should first place it in a cool place. High temperature can easily cause its chemical reaction, or cause decomposition and deterioration. A cool environment can slow down its chemical change rate and maintain the stability of its chemical structure. Furthermore, keep it dry. Moisture is very easy to attack this substance, causing adverse reactions such as hydrolysis. If the environment is humid, moisture interacts with the compound, or changes its chemical properties, reducing its purity and utility. Therefore, the storage place must be dry and dry.
In addition, sealed storage is also the key. This substance is exposed to air and easily reacts with gases such as oxygen and carbon dioxide. Sealed containers can effectively isolate external gases and avoid unnecessary reactions. For example, use glass bottles or plastic bottles, and ensure that the cap is tightly sealed.
Store away from sources of fire and strong oxidants. This compound may be flammable, in case of open flames, hot topics or combustion hazards. Strong oxidants can also react violently with the like, endangering safety. Methyl 3-iodopyridine-4-carboxylate should be stored in a cool, dry, sealed place, away from sources of ignition and strong oxidants, so as to maximize its quality and stability for subsequent use.