methyl 3-hydroxypyridine-2-carboxylate

Methyl 3-hydroxypyridine-2-carboxylic acid ester is an organic compound. It has unique chemical properties, let me come one by one.
This compound contains a pyridine ring, which gives it certain stability and aromaticity. The nitrogen atom of the pyridine ring can interact with other molecules or ions through coordination bonds due to its lone pair of electrons. The hydroxyl group on the ring is active in nature. The hydroxyl group can participate in many chemical reactions, such as reacting with acids to form esters and reacting with bases to form salts. The hydrogen atom of the hydroxyl group has a certain acidity. Although the acidity is weaker than that of common inorganic acids, under the action of appropriate bases, hydrogen ions can be dissociated.
Furthermore, it contains carboxylic acid ester groups. The presence of this group gives the compound hydrolytic properties. Under acidic or alkaline conditions, ester groups are easily hydrolyzed. In acidic media, the hydrolysis reaction is reversible, resulting in 3-hydroxypyridine-2-carboxylic acid and methanol; in alkaline environments, the hydrolysis is more complete, resulting in carboxylate and methanol. This hydrolytic property is of great significance in the fields of organic synthesis and drug metabolism.
In addition, due to the different electronegativity of different atoms in the molecule, the distribution of electron clouds is uneven, giving the molecule a certain polarity. This polarity affects its solubility, and its solubility is better in polar solvents than in non-polar solvents. And because of its structural characteristics, it shows potential application value in the fields of medicinal chemistry and materials science, and can be used as a key intermediate for the synthesis of new drugs or functional materials.

Methyl 3-hydroxypyridine-2-carboxylate has a wide range of uses and is used in various fields such as chemical industry and medicine.
In the field of chemical industry, this is a key raw material for organic synthesis. Many compounds with specific functions can be derived through a series of delicate chemical reactions. For example, by condensation with specific reagents, complex cyclic structures can be constructed. This cyclic product is of great significance in the field of research and development of new materials. It can be used to create materials with unique electrical and optical properties, and help innovation in electronic devices, optical instruments and other industries.
In the field of medicine, its role is also crucial. Due to its specific chemical structure and activity, it may become an important intermediate in drug synthesis. The drugs synthesized from it may have antibacterial, anti-inflammatory, anti-tumor and other effects. Studies have shown that some compounds prepared from this as a starting material through multi-step reaction have significant inhibitory effects on specific cancer cells, opening up new paths for the research and development of anti-cancer drugs.
In addition, in the field of agricultural chemicals, it may participate in the synthesis of pesticides and plant growth regulators with special effects. It can precisely regulate the growth process of plants, improve the disease resistance and stress resistance of crops, and then help agricultural yield increase.
In summary, methyl 3-hydroxypyridine-2-carboxylate has important value in many fields, and its application prospects will be broader with the advancement of science and technology.

There are many different methods for the synthesis of fugmethyl-3-hydroxypyridine-2-carboxylic acid esters. One common one is to start from pyridine-2,3-dicarboxylic acid. First, pyridine-2,3-dicarboxylic acid and methanol are esterified under the catalysis of strong acids such as sulfuric acid. This reaction requires heating and reflux to make the two fully react. Pyridine-2,3-dicarboxylic acid biscarboxylic group reacts with methanol to form methyl ester group, respectively, to obtain pyridine-2,3-dicarboxylic acid dimethyl ester.
Then, dimethyl pyridine-2,3-dicarboxylate is selectively reduced. Suitable reducing agents can be used, such as sodium borohydride-zinc chloride system. In this system, sodium borohydride provides hydrogen anions, zinc chloride plays an activation role, and the two synergistically reduce one methyl ester group in dimethyl pyridine-2,3-dicarboxylate to a hydroxyl group, and the other methyl ester group is retained, resulting in methyl-3-hydroxypyridine-2-carboxylate.
There is also a synthetic method, using 3-hydroxypyridine-2-carboxylic acid as the starting material. Mix 3-hydroxypyridine-2-carboxylic acid with methanol, add appropriate dehydrating agent, such as dicyclohexyl carbodiimide (DCC), and add 4-dimethylaminopyridine (DMAP) as catalyst. DCC can promote the dehydration of carboxylic acid and alcohol to form ester bonds, DMAP can speed up the reaction rate. Stir the reaction at a suitable temperature, and when the reaction is completed, after separation and purification, methyl-3-hydroxypyridine-2-carboxylic acid esters can also be obtained. These two methods have their own advantages and disadvantages. In practical application, according to the availability of raw materials, cost and reaction conditions, choose the best one.

The price of methyl 3-hydroxypyridine-2-carboxylic acid ester in the market has changed for many reasons, and it is difficult to determine the exact number. Looking at the "Tiangong Kaiwu", although the methods of creation are detailed in it, the price of methyl 3-hydroxypyridine-2-carboxylic acid ester is not involved. The reason is that the book was written in the past, when chemical synthesis was not as developed as it is today, and such fine chemicals may not yet exist. Even if they exist, it is not the focus of the book.
In this world, the change in the price of methyl 3-hydroxypyridine-2-carboxylic acid ester depends on the purity. If the purity is extremely high and there are few impurities, the price will be high; on the contrary, if the purity is low, the price will be low. Second, the trend of supply and demand is also heavy. If there are many people in the market, but there are few products, the price will rise; if the supply exceeds the demand, the price will drop. Furthermore, the origin and production method are also related to its price. Different origins have different prices due to differences in raw material costs, labor costs, and transportation costs. The simplicity of the production method and the level of the cost all affect the price.
And the chemical market is changing, the fluctuation of raw material prices, the ease of policies and regulations, and the turbulence of the international situation can all make the price of methyl 3-hydroxypyridine-2-carboxylate fluctuate. Therefore, if you want to know the exact price, you should carefully consider the current market situation, consult chemical suppliers, traders, or obtain a near-real price.

Methyl 3-hydroxypyridine-2-carboxylic acid ester is one of the organic compounds. When storing and transporting, all kinds of precautions are essential.
Let's talk about storage first. This compound should be placed in a cool, dry and well-ventilated place. Cover because of its nature or affected by temperature and humidity, if it is placed in a high temperature and humid place, it may cause decomposition and deterioration. And it needs to be kept away from fire and heat sources. Because of its flammability, it is easy to cause danger in case of open flames and hot topics. It should also be stored separately from oxidants, acids, bases, etc., to avoid mixed storage to prevent chemical reactions.
As for transportation, the transportation vehicle must ensure that the vehicle is in good condition and has corresponding fire and explosion-proof measures. During transportation, it should be handled lightly and lightly, and should not be loaded and unloaded brutally, so as to avoid packaging damage and compound leakage. And when transporting, it should follow the specified route and do not stop in densely populated areas and open flames. At the same time, transporters need professional training to be familiar with the characteristics of the compound and emergency treatment methods. In the event of leakage and other accidents, they can be disposed of quickly and properly to prevent the harm from expanding. In this way, the safety of methyl 3-hydroxypyridine-2-carboxylate during storage and transportation can be ensured.