Methyl 3-chloropyridine-2-carboxylate

Methyl 3-chloropyridine-2-carboxylic acid esters are crucial compounds in the field of organic synthesis. They have a wide range of uses and can be used as key intermediates in the field of medicinal chemistry to prepare various biologically active drug molecules. Due to the unique structure of the pyridine ring and the chlorine atom and ester group, it has the potential to interact with biological targets and can effectively participate in the design and construction of drug molecules.
In the field of pesticides, methyl 3-chloropyridine-2-carboxylic acid esters are also of great value. It can be chemically converted to prepare pesticide products with insecticidal, bactericidal or herbicidal effects. Its structural properties enable it to precisely act on specific physiological processes of pests, pathogens or weeds, achieving the purpose of efficient control.
Furthermore, in the field of materials science, this compound can be used as a starting material and through specific chemical reactions, polymer materials with unique properties can be synthesized. For example, through polymerization, materials with special electrical, optical or mechanical properties can be prepared, which are used in electronic devices, optical instruments and other fields.
With its unique chemical structure, this compound is an indispensable basic raw material in many fields such as pharmaceuticals, pesticides and materials science, and plays a pivotal role in promoting the development of related fields.

There are many different methods for synthesizing methyl 3-chloropyridine-2-carboxylic acid esters. One common one is to use 3-chloropyridine-2-carboxylic acid and methanol as raw materials, supplemented with concentrated sulfuric acid or p-toluenesulfonic acid as catalysts, and perform esterification in a heated reflux state. In this process, the acid and alcohol are catalyzed to dehydrate between molecules to form esters. The reaction formula is roughly as follows: 3-chloropyridine-2-carboxylic acid + methanol $\ underset {heated reflux} {\ overset {catalyst} {\ rightleftharpoons}} $methyl 3-chloropyridine-2-carboxylic acid ester + water. After the reaction is completed, the product can be purified by neutralization, extraction, distillation, etc.
Second, 3-chloropyridine-2-carboxylic acid can be converted to acyl chloride first, such as by reacting with dichloroxy sulfoxide to obtain 3-chloropyridine-2-carboxylic acid chloride. The target product can also be obtained under milder conditions. Due to the high activity of acyl chloride, the reaction of this path is easy to proceed. The reaction formulas are: 3-chloropyridine-2-carboxylic acid + SOCl ³ $\ longrightarrow $3-chloropyridine-2-carboxylic chloride + SO ³ + HCl; 3-chloropyridine-2-carboxylate + methanol $\ longrightarrow $methyl 3-chloropyridine-2-carboxylate + HCl. Appropriate purification methods are also required in the future.
Or from other compounds containing pyridine structures, chlorine atoms and ester groups are gradually introduced through multi-step reactions to achieve the purpose of synthesis. However, such methods or steps are cumbersome, and the reaction conditions need to be carefully controlled to ensure the yield and selectivity of each step of the reaction. In short, the synthesis method has advantages and disadvantages, and the appropriate method must be carefully selected according to actual needs, such as raw material availability, cost, yield and purity requirements.

Methyl 3-chloropyridine-2-carboxylic acid ester is an important compound in the field of organic chemistry. It has unique physical properties, let me tell you one by one.
Looking at its properties, under room temperature and pressure, it is mostly colorless to light yellow liquid. This characteristic has a great impact on the operation and process of the reaction in many organic synthesis reactions. Because it is in a liquid state, when participating in the reaction, it is more fully contacted with other reactants, which can make the reaction proceed more efficiently.
When it comes to boiling point, it is between 240 and 250 ° C. This boiling point value is of great significance. In the separation and purification process of compounds, methyl 3-chloropyridine-2-carboxylic acid ester can be precisely separated from the reaction mixture by distillation according to its boiling point characteristics, ensuring the purity of the product.
As for the melting point, it is about -10 ° C. The low melting point indicates that the compound can melt at a relatively low temperature. When storing and transporting, it is necessary to pay attention to temperature conditions to prevent its state from changing due to temperature fluctuations and affecting quality.
In terms of density, it is about 1.28 g/cm ³. This density value plays a key role in its distribution in the solution and its mixing ratio with other substances. When preparing a solution of a specific concentration, the density data provides an important basis for precise preparation.
In terms of solubility, it is soluble in a variety of organic solvents, such as ethanol, ether, dichloromethane, etc. Good solubility makes it flexible as a reaction medium or participate in various chemical reactions in organic synthesis. However, the solubility in water is very small, and this characteristic needs to be taken into account when treating wastewater containing this compound or performing phase transfer reactions. The physical properties of methyl 3-chloropyridine-2-carboxylate above
are key parameters in many fields such as organic synthesis, drug development, and materials science, and are of great significance to related research and production practices.

Methyl 3-chloropyridine-2-carboxylate, in the chemical market, its price is really difficult to determine. Due to the ever-changing market conditions, it is still fickle. Its price is often influenced by many factors, and the first to bear the brunt is the raw material for production. The abundance of raw materials is related to their price. If the raw materials are convenient, the supply of goods is abundant, and the price may become stable and cheap; on the contrary, if the raw materials are scarce and difficult to pick, the price will rise.
Furthermore, the simplicity of the process is also the key. If the preparation method is exquisite and efficient, with less energy consumption and more output, the cost will decrease, and the price will follow; however, if the process is complicated, many steps and harsh conditions are required, manpower and material resources are consumed, and the price will be difficult to be close to the people.
The balance between supply and demand in the market is also a major factor affecting the price. If there are many people who need it at a time, the demand is greater than the supply, and the price will rise; if the market is saturated and the supply exceeds the demand, the merchant will sell its goods at a lower price.
Looking at the changes in the prices of chemical products in the past, it often moves with various factors. Methyl 3-chloropyridine-2-carboxylate is no exception. Although there is no exact price for you, if you carefully observe the market according to the above reasons, you can have a rough guess at its price. To know the real-time price, you need to ask the chemical companies or observe the latest market conditions of the trading platforms before you can obtain a letter of approval.

Methyl 3-chloropyridine-2-carboxylic acid ester is an organic compound, and many matters must be paid attention to when storing and transporting.
First, the storage environment is very important. It should be placed in a cool, dry and well-ventilated place. This compound is quite sensitive to humidity, and the humid environment can easily cause chemical reactions such as hydrolysis, which in turn affects the quality. Therefore, it is necessary to ensure that the storage place is dry and moisture-free. And the temperature should not be too high. High temperature may cause changes in its chemical properties, or even cause decomposition.
Second, because it is a chemical product, it must be stored separately from oxidants, acids, bases and other substances. When these substances come into contact with it, they are prone to violent chemical reactions, or serious accidents such as fires and explosions.
Third, the packaging must be tight and stable during transportation. Choose suitable packaging materials to prevent the package from being damaged due to bumps and collisions during transportation, resulting in the leakage of methyl 3-chloropyridine-2-carboxylate.
Fourth, transportation personnel should be familiar with the characteristics of this compound and emergency treatment methods. In the event of an accident such as leakage, appropriate measures can be taken immediately to avoid the expansion of the hazard. For example, if a leak occurs, the surrounding personnel should be quickly evacuated to isolate the leakage area and prevent unrelated personnel from approaching.
Fifth, no matter whether it is stored or transported, it must strictly follow the relevant regulations and standards. This is not only to ensure the safety of personnel and environmental safety, but also a necessary requirement for legal compliance. In this way, the safety and stability of methyl 3-chloropyridine-2-carboxylate during storage and transportation can be ensured.